Impact of anatomical and functional severity of coronary atherosclerotic plaques on the transmural perfusion gradient: a [O-15]H2O PET study

I. Danad, P.G. Raijmakers, H.J. Harms, M.W. Heymans, N. van Royen, M. Lubberink, R. Boellaard, A.C. van Rossum, A.A. Lammertsma, P. Knaapen

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Background :Myocardial ischaemia occurs principally in the subendocardial layer, whereas conventional myocardial perfusion imaging provides no information on the transmural myocardial blood flow (MBF) distribution. Subendocardial perfusion measurements and quantification of the transmural perfusion gradient (TPG) could be more sensitive and specific for the detection of coronary artery disease (CAD). The current study aimed to determine the impact of lesion severity as assessed by the fractional flow reserve (FFR) on subendocardial perfusion and the TPG using
Original languageEnglish
Pages (from-to)2094-2105
JournalEuropean Heart Journal
Volume35
Issue number31
DOIs
Publication statusPublished - 2014

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