Impact of In Utero Exposure to Antiepileptic Drugs on Neonatal Brain Function

Anton Tokariev; Michael Breakspear; Mari Videman; Susanna Stjerna; Lianne H. Scholtens; Martijn P. Van Den Heuvel; Luca Cocchi; Sampsa Vanhatalo

doi:10.1093/cercor/bhab338

Impact of In Utero Exposure to Antiepileptic Drugs on Neonatal Brain Function

Anton Tokariev^*, Michael Breakspear, Mari Videman, Susanna Stjerna, Lianne H. Scholtens, Martijn P. Van Den Heuvel, Luca Cocchi, Sampsa Vanhatalo

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

In utero brain development underpins brain health across the lifespan but is vulnerable to physiological and pharmacological perturbation. Here, we show that antiepileptic medication during pregnancy impacts on cortical activity during neonatal sleep, a potent indicator of newborn brain health. These effects are evident in frequency-specific functional brain networks and carry prognostic information for later neurodevelopment. Notably, such effects differ between different antiepileptic drugs that suggest neurodevelopmental adversity from exposure to antiepileptic drugs and not maternal epilepsy per se. This work provides translatable bedside metrics of brain health that are sensitive to the effects of antiepileptic drugs on postnatal neurodevelopment and carry direct prognostic value.

Original language	English
Article number	338
Pages (from-to)	2385-2397
Number of pages	13
Journal	Cerebral Cortex
Volume	32
Issue number	11
Early online date	29 Sept 2021
DOIs	https://doi.org/10.1093/cercor/bhab338
Publication status	Published - 1 Jun 2022

Bibliographical note

Funding Information:
L.C. was supported by National Health and Medical Research Council (1138711 and 2001283). M.P.v.d.H. was supported by an ALW open (ALWOP.179) and VIDI (452-16-015) grant fromthe Netherlands Organization for Scientific Research (NWO) and an ERC Consolidator of the European Research Council (101001062).

Publisher Copyright:
© 2021 The Author(s) 2021. Published by Oxford University Press.

Funding

L.C. was supported by National Health and Medical Research Council (1138711 and 2001283). M.P.v.d.H. was supported by an ALW open (ALWOP.179) and VIDI (452-16-015) grant fromthe Netherlands Organization for Scientific Research (NWO) and an ERC Consolidator of the European Research Council (101001062).

Funders	Funder number
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
European Research Council	101001062
National Health and Medical Research Council	1138711, 2001283, 452-16-015
Research Council of Finland	321235

Keywords

antiepileptic drug
brain network
infant
neurodevelopment
neurology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/cercor/bhab338

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title = "Impact of In Utero Exposure to Antiepileptic Drugs on Neonatal Brain Function",

abstract = "In utero brain development underpins brain health across the lifespan but is vulnerable to physiological and pharmacological perturbation. Here, we show that antiepileptic medication during pregnancy impacts on cortical activity during neonatal sleep, a potent indicator of newborn brain health. These effects are evident in frequency-specific functional brain networks and carry prognostic information for later neurodevelopment. Notably, such effects differ between different antiepileptic drugs that suggest neurodevelopmental adversity from exposure to antiepileptic drugs and not maternal epilepsy per se. This work provides translatable bedside metrics of brain health that are sensitive to the effects of antiepileptic drugs on postnatal neurodevelopment and carry direct prognostic value. ",

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AU - Van Den Heuvel, Martijn P.

AU - Cocchi, Luca

AU - Vanhatalo, Sampsa

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Impact of In Utero Exposure to Antiepileptic Drugs on Neonatal Brain Function

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

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