Improving the sensitivity of HPLC absorption detection by cavity ring-down spectroscopy in a liquid-only cavity

L. van der Sneppen, A. Wiskerke, F. Ariese, C. Gooijer, W.M.G. Ubachs

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

A previously described liquid-only cavity flow cell is used to assess the feasibility of improving absorbance detection limits in liquid chromatography (LC) using cavity ring-down spectroscopy (CRDS). In this miniaturized cavity there is an optical path length of only 2 mm between the mirrors, which at the same time form the walls of the flow cell. Typical ring-down times are 65-75 ns for the eluent blank. The performance of the presented flow cell compares favorably to conventional absorbance detection: the baseline noise is determined to be 2.7 × 10
Original languageEnglish
Pages (from-to)2-6
JournalAnalytica Chimica Acta
Volume558
Issue number1-2
DOIs
Publication statusPublished - 2006

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