Improving the sensitivity of HPLC absorption detection by cavity ring-down spectroscopy in a liquid-only cavity

L. van der Sneppen; A. Wiskerke; F. Ariese; C. Gooijer; W.M.G. Ubachs

doi:10.1016/j.aca.2005.11.022

Improving the sensitivity of HPLC absorption detection by cavity ring-down spectroscopy in a liquid-only cavity

L. van der Sneppen
, A. Wiskerke
, F. Ariese
, C. Gooijer
, W.M.G. Ubachs

Quantum Metrology & Laser Applications

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

A previously described liquid-only cavity flow cell is used to assess the feasibility of improving absorbance detection limits in liquid chromatography (LC) using cavity ring-down spectroscopy (CRDS). In this miniaturized cavity there is an optical path length of only 2 mm between the mirrors, which at the same time form the walls of the flow cell. Typical ring-down times are 65-75 ns for the eluent blank. The performance of the presented flow cell compares favorably to conventional absorbance detection: the baseline noise is determined to be 2.7 × 10

Original language	English
Pages (from-to)	2-6
Journal	Analytica Chimica Acta
Volume	558
Issue number	1-2
DOIs	https://doi.org/10.1016/j.aca.2005.11.022
Publication status	Published - 2006

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SDG 6 Clean Water and Sanitation

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10.1016/j.aca.2005.11.022

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abstract = "A previously described liquid-only cavity flow cell is used to assess the feasibility of improving absorbance detection limits in liquid chromatography (LC) using cavity ring-down spectroscopy (CRDS). In this miniaturized cavity there is an optical path length of only 2 mm between the mirrors, which at the same time form the walls of the flow cell. Typical ring-down times are 65-75 ns for the eluent blank. The performance of the presented flow cell compares favorably to conventional absorbance detection: the baseline noise is determined to be 2.7 × 10",

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AU - Wiskerke, A.

AU - Ariese, F.

AU - Gooijer, C.

AU - Ubachs, W.M.G.

PY - 2006

Y1 - 2006

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AB - A previously described liquid-only cavity flow cell is used to assess the feasibility of improving absorbance detection limits in liquid chromatography (LC) using cavity ring-down spectroscopy (CRDS). In this miniaturized cavity there is an optical path length of only 2 mm between the mirrors, which at the same time form the walls of the flow cell. Typical ring-down times are 65-75 ns for the eluent blank. The performance of the presented flow cell compares favorably to conventional absorbance detection: the baseline noise is determined to be 2.7 × 10

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Improving the sensitivity of HPLC absorption detection by cavity ring-down spectroscopy in a liquid-only cavity

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