Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

M.A. Nalls; V. Plagnol; D.G. Hernandez; M. Sharma; U.M. Sheerin; M. Saad; J. Simon-Sanchez; C. Schulte; S. Lesage; S. Sveinbjornsdottir; S. Arepalli; R. Barker; Y. Ben-Shlomo; H.W. Berendse; D. Berg; K. Bhatia; R.M.A. de Bie; A. Biffi; B. Bloem; Z. Bochdanovits; M. Bonin; J.M. Bras; K. Brockmann; J. Brooks; D.J. Burn; G. Charlesworth; H.L. Chen; P.F. Chinnery; S. Chong; C.E. Clarke; M.R. Cookson; J.M. Cooper; J.C. Corvol; C. Counsell; P. Damier; J.F. Dartigues; P. Deloukas; G. Deuschl; D.T. Dexter; K.D. van Dijk; A. Dillman; F. Durif; A. Durr; S. Edkins; J.R. Evans; T. Foltynie; J.J. Gao; M. Gardner; J.R. Gibbs; A. Goate; E. Gray; R. Guerreiro; O. Gustafsson; C Harris; J.J. van Hilten; A. Hofman; A. Hollenbeck; J. Holton; M. Hu; X.M. Huang; H. Huber; G. Hudson; S.E. Hunt; J. Huttenlocher; T. Illig; P.V. Jonsson; J.C. Lambert; C. Langford; A. Lees; P. Lichtner; P. Limousin; G. Lopez; D. Lorenz; A. McNeill; C. Moorby; M. Moore; H.R. Morris; K.E. Morrison; E. Mudanohwo; S.S. O'Sullivan; J. Pearson; J.S. Perlmutter; H. Petursson; P. Pollak; B. Post; S. Potter; B. Ravina; T. Revesz; O. Riess; F. Rivadeneira; P. Rizzu; M. Ryten; S. Sawcer; A. Schapira; H. Scheffer; K. Shaw; I. Shoulson; E. Sidransky; C. Smith; P. Heutink; A.B. Singleton; N.W. Wood

doi:10.1016/S0140-6736(10)62345-8

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

M.A. Nalls, V. Plagnol, D.G. Hernandez, M. Sharma, U.M. Sheerin, M. Saad, J. Simon-Sanchez, C. Schulte, S. Lesage, S. Sveinbjornsdottir, S. Arepalli, R. Barker, Y. Ben-Shlomo, H.W. Berendse, D. Berg, K. Bhatia, R.M.A. de Bie, A. Biffi, B. Bloem, Z. BochdanovitsM. Bonin, J.M. Bras, K. Brockmann, J. Brooks, D.J. Burn, G. Charlesworth, H.L. Chen, P.F. Chinnery, S. Chong, C.E. Clarke, M.R. Cookson, J.M. Cooper, J.C. Corvol, C. Counsell, P. Damier, J.F. Dartigues, P. Deloukas, G. Deuschl, D.T. Dexter, K.D. van Dijk, A. Dillman, F. Durif, A. Durr, S. Edkins, J.R. Evans, T. Foltynie, J.J. Gao, M. Gardner, J.R. Gibbs, A. Goate, E. Gray, R. Guerreiro, O. Gustafsson, C Harris, J.J. van Hilten, A. Hofman, A. Hollenbeck, J. Holton, M. Hu, X.M. Huang, H. Huber, G. Hudson, S.E. Hunt, J. Huttenlocher, T. Illig, P.V. Jonsson, J.C. Lambert, C. Langford, A. Lees, P. Lichtner, P. Limousin, G. Lopez, D. Lorenz, A. McNeill, C. Moorby, M. Moore, H.R. Morris, K.E. Morrison, E. Mudanohwo, S.S. O'Sullivan, J. Pearson, J.S. Perlmutter, H. Petursson, P. Pollak, B. Post, S. Potter, B. Ravina, T. Revesz, O. Riess, F. Rivadeneira, P. Rizzu, M. Ryten, S. Sawcer, A. Schapira, H. Scheffer, K. Shaw, I. Shoulson, E. Sidransky, C. Smith, P. Heutink, A.B. Singleton, N.W. Wood

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background: Genome-wide association studies (GWAS) for Parkinson's disease have linked two loci (MAPT and SNCA) to risk of Parkinson's disease. We aimed to identify novel risk loci for Parkinson's disease. Methods: We did a meta-analysis of datasets from five Parkinson's disease GWAS from the USA and Europe to identify loci associated with Parkinson's disease (discovery phase). We then did replication analyses of significantly associated loci in an independent sample series. Estimates of population-attributable risk were calculated from estimates from the discovery and replication phases combined, and risk-profile estimates for loci identified in the discovery phase were calculated. Findings: The discovery phase consisted of 5333 case and 12019 control samples, with genotyped and imputed data at 7689524 SNPs. The replication phase consisted of 7053 case and 9007 control samples. We identified 11 loci that surpassed the threshold for genome-wide significance (p<5×10

Original language	English
Pages (from-to)	641-649
Journal	Lancet
Volume	377
Issue number	9766
DOIs	https://doi.org/10.1016/S0140-6736(10)62345-8
Publication status	Published - 2011

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Nalls, M. A., Plagnol, V., Hernandez, D. G., Sharma, M., Sheerin, U. M., Saad, M., Simon-Sanchez, J., Schulte, C., Lesage, S., Sveinbjornsdottir, S., Arepalli, S., Barker, R., Ben-Shlomo, Y., Berendse, H. W., Berg, D., Bhatia, K., de Bie, R. M. A., Biffi, A., Bloem, B., ... Wood, N. W. (2011). Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet, 377(9766), 641-649. https://doi.org/10.1016/S0140-6736(10)62345-8

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title = "Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies",

abstract = "Background: Genome-wide association studies (GWAS) for Parkinson's disease have linked two loci (MAPT and SNCA) to risk of Parkinson's disease. We aimed to identify novel risk loci for Parkinson's disease. Methods: We did a meta-analysis of datasets from five Parkinson's disease GWAS from the USA and Europe to identify loci associated with Parkinson's disease (discovery phase). We then did replication analyses of significantly associated loci in an independent sample series. Estimates of population-attributable risk were calculated from estimates from the discovery and replication phases combined, and risk-profile estimates for loci identified in the discovery phase were calculated. Findings: The discovery phase consisted of 5333 case and 12019 control samples, with genotyped and imputed data at 7689524 SNPs. The replication phase consisted of 7053 case and 9007 control samples. We identified 11 loci that surpassed the threshold for genome-wide significance (p<5×10",

author = "M.A. Nalls and V. Plagnol and D.G. Hernandez and M. Sharma and U.M. Sheerin and M. Saad and J. Simon-Sanchez and C. Schulte and S. Lesage and S. Sveinbjornsdottir and S. Arepalli and R. Barker and Y. Ben-Shlomo and H.W. Berendse and D. Berg and K. Bhatia and {de Bie}, R.M.A. and A. Biffi and B. Bloem and Z. Bochdanovits and M. Bonin and J.M. Bras and K. Brockmann and J. Brooks and D.J. Burn and G. Charlesworth and H.L. Chen and P.F. Chinnery and S. Chong and C.E. Clarke and M.R. Cookson and J.M. Cooper and J.C. Corvol and C. Counsell and P. Damier and J.F. Dartigues and P. Deloukas and G. Deuschl and D.T. Dexter and {van Dijk}, K.D. and A. Dillman and F. Durif and A. Durr and S. Edkins and J.R. Evans and T. Foltynie and J.J. Gao and M. Gardner and J.R. Gibbs and A. Goate and E. Gray and R. Guerreiro and O. Gustafsson and C Harris and {van Hilten}, J.J. and A. Hofman and A. Hollenbeck and J. Holton and M. Hu and X.M. Huang and H. Huber and G. Hudson and S.E. Hunt and J. Huttenlocher and T. Illig and P.V. Jonsson and J.C. Lambert and C. Langford and A. Lees and P. Lichtner and P. Limousin and G. Lopez and D. Lorenz and A. McNeill and C. Moorby and M. Moore and H.R. Morris and K.E. Morrison and E. Mudanohwo and S.S. O'Sullivan and J. Pearson and J.S. Perlmutter and H. Petursson and P. Pollak and B. Post and S. Potter and B. Ravina and T. Revesz and O. Riess and F. Rivadeneira and P. Rizzu and M. Ryten and S. Sawcer and A. Schapira and H. Scheffer and K. Shaw and I. Shoulson and E. Sidransky and C. Smith and P. Heutink and A.B. Singleton and N.W. Wood",

year = "2011",

doi = "10.1016/S0140-6736(10)62345-8",

language = "English",

volume = "377",

pages = "641--649",

journal = "Lancet",

issn = "0140-6736",

publisher = "Elsevier Limited",

number = "9766",

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Nalls, MA, Plagnol, V, Hernandez, DG, Sharma, M, Sheerin, UM, Saad, M, Simon-Sanchez, J, Schulte, C, Lesage, S, Sveinbjornsdottir, S, Arepalli, S, Barker, R, Ben-Shlomo, Y, Berendse, HW, Berg, D, Bhatia, K, de Bie, RMA, Biffi, A, Bloem, B, Bochdanovits, Z, Bonin, M, Bras, JM, Brockmann, K, Brooks, J, Burn, DJ, Charlesworth, G, Chen, HL, Chinnery, PF, Chong, S, Clarke, CE, Cookson, MR, Cooper, JM, Corvol, JC, Counsell, C, Damier, P, Dartigues, JF, Deloukas, P, Deuschl, G, Dexter, DT, van Dijk, KD, Dillman, A, Durif, F, Durr, A, Edkins, S, Evans, JR, Foltynie, T, Gao, JJ, Gardner, M, Gibbs, JR, Goate, A, Gray, E, Guerreiro, R, Gustafsson, O, Harris, C, van Hilten, JJ, Hofman, A, Hollenbeck, A, Holton, J, Hu, M, Huang, XM, Huber, H, Hudson, G, Hunt, SE, Huttenlocher, J, Illig, T, Jonsson, PV, Lambert, JC, Langford, C, Lees, A, Lichtner, P, Limousin, P, Lopez, G, Lorenz, D, McNeill, A, Moorby, C, Moore, M, Morris, HR, Morrison, KE, Mudanohwo, E, O'Sullivan, SS, Pearson, J, Perlmutter, JS, Petursson, H, Pollak, P, Post, B, Potter, S, Ravina, B, Revesz, T, Riess, O, Rivadeneira, F, Rizzu, P, Ryten, M, Sawcer, S, Schapira, A, Scheffer, H, Shaw, K, Shoulson, I, Sidransky, E, Smith, C, Heutink, P, Singleton, AB & Wood, NW 2011, 'Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies', Lancet, vol. 377, no. 9766, pp. 641-649. https://doi.org/10.1016/S0140-6736(10)62345-8

TY - JOUR

T1 - Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

AU - Nalls, M.A.

AU - Plagnol, V.

AU - Hernandez, D.G.

AU - Sharma, M.

AU - Sheerin, U.M.

AU - Saad, M.

AU - Simon-Sanchez, J.

AU - Schulte, C.

AU - Lesage, S.

AU - Sveinbjornsdottir, S.

AU - Arepalli, S.

AU - Barker, R.

AU - Ben-Shlomo, Y.

AU - Berendse, H.W.

AU - Berg, D.

AU - Bhatia, K.

AU - de Bie, R.M.A.

AU - Biffi, A.

AU - Bloem, B.

AU - Bochdanovits, Z.

AU - Bonin, M.

AU - Bras, J.M.

AU - Brockmann, K.

AU - Brooks, J.

AU - Burn, D.J.

AU - Charlesworth, G.

AU - Chen, H.L.

AU - Chinnery, P.F.

AU - Chong, S.

AU - Clarke, C.E.

AU - Cookson, M.R.

AU - Cooper, J.M.

AU - Corvol, J.C.

AU - Counsell, C.

AU - Damier, P.

AU - Dartigues, J.F.

AU - Deloukas, P.

AU - Deuschl, G.

AU - Dexter, D.T.

AU - van Dijk, K.D.

AU - Dillman, A.

AU - Durif, F.

AU - Durr, A.

AU - Edkins, S.

AU - Evans, J.R.

AU - Foltynie, T.

AU - Gao, J.J.

AU - Gardner, M.

AU - Gibbs, J.R.

AU - Goate, A.

AU - Gray, E.

AU - Guerreiro, R.

AU - Gustafsson, O.

AU - Harris, C

AU - van Hilten, J.J.

AU - Hofman, A.

AU - Hollenbeck, A.

AU - Holton, J.

AU - Hu, M.

AU - Huang, X.M.

AU - Huber, H.

AU - Hudson, G.

AU - Hunt, S.E.

AU - Huttenlocher, J.

AU - Illig, T.

AU - Jonsson, P.V.

AU - Lambert, J.C.

AU - Langford, C.

AU - Lees, A.

AU - Lichtner, P.

AU - Limousin, P.

AU - Lopez, G.

AU - Lorenz, D.

AU - McNeill, A.

AU - Moorby, C.

AU - Moore, M.

AU - Morris, H.R.

AU - Morrison, K.E.

AU - Mudanohwo, E.

AU - O'Sullivan, S.S.

AU - Pearson, J.

AU - Perlmutter, J.S.

AU - Petursson, H.

AU - Pollak, P.

AU - Post, B.

AU - Potter, S.

AU - Ravina, B.

AU - Revesz, T.

AU - Riess, O.

AU - Rivadeneira, F.

AU - Rizzu, P.

AU - Ryten, M.

AU - Sawcer, S.

AU - Schapira, A.

AU - Scheffer, H.

AU - Shaw, K.

AU - Shoulson, I.

AU - Sidransky, E.

AU - Smith, C.

AU - Heutink, P.

AU - Singleton, A.B.

AU - Wood, N.W.

PY - 2011

Y1 - 2011

N2 - Background: Genome-wide association studies (GWAS) for Parkinson's disease have linked two loci (MAPT and SNCA) to risk of Parkinson's disease. We aimed to identify novel risk loci for Parkinson's disease. Methods: We did a meta-analysis of datasets from five Parkinson's disease GWAS from the USA and Europe to identify loci associated with Parkinson's disease (discovery phase). We then did replication analyses of significantly associated loci in an independent sample series. Estimates of population-attributable risk were calculated from estimates from the discovery and replication phases combined, and risk-profile estimates for loci identified in the discovery phase were calculated. Findings: The discovery phase consisted of 5333 case and 12019 control samples, with genotyped and imputed data at 7689524 SNPs. The replication phase consisted of 7053 case and 9007 control samples. We identified 11 loci that surpassed the threshold for genome-wide significance (p<5×10

AB - Background: Genome-wide association studies (GWAS) for Parkinson's disease have linked two loci (MAPT and SNCA) to risk of Parkinson's disease. We aimed to identify novel risk loci for Parkinson's disease. Methods: We did a meta-analysis of datasets from five Parkinson's disease GWAS from the USA and Europe to identify loci associated with Parkinson's disease (discovery phase). We then did replication analyses of significantly associated loci in an independent sample series. Estimates of population-attributable risk were calculated from estimates from the discovery and replication phases combined, and risk-profile estimates for loci identified in the discovery phase were calculated. Findings: The discovery phase consisted of 5333 case and 12019 control samples, with genotyped and imputed data at 7689524 SNPs. The replication phase consisted of 7053 case and 9007 control samples. We identified 11 loci that surpassed the threshold for genome-wide significance (p<5×10

U2 - 10.1016/S0140-6736(10)62345-8

DO - 10.1016/S0140-6736(10)62345-8

M3 - Article

SN - 0140-6736

VL - 377

SP - 641

EP - 649

JO - Lancet

JF - Lancet

IS - 9766

ER -

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

Abstract

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