In-house validation of a liquid chromatography tandem mass spectrometry method for the analysis of lipophilic marine toxins in shellfish using matrix-matched calibration

A. Gerssen; E.H.W. van Olst; P.P.J. Mulder; J. de Boer

doi:10.1007/s00216-010-3886-2

In-house validation of a liquid chromatography tandem mass spectrometry method for the analysis of lipophilic marine toxins in shellfish using matrix-matched calibration

A. Gerssen
, E.H.W. van Olst
, P.P.J. Mulder
, J. de Boer

Chemistry and Biology

Research output: Contribution to Journal › Article › Academic › peer-review

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Abstract

A liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the quantitative analysis of lipophilic marine toxins in shellfish extracts (mussel, oyster, cockle and clam) was validated in-house using European Union (EU) Commission Decision 2002/657/EC as a guideline. The validation included the toxins okadaic acid (OA), yessotoxin (YTX), azaspiracid-1 (AZA1), pectenotoxin-2 (PTX2) and 13-desmethyl spirolide-C (SPX1). Validation was performed at 0.5, 1 and 1.5 times the current EU permitted levels, which are 160 μg kg

Original language	English
Pages (from-to)	3079-3088
Number of pages	10
Journal	Analytical and Bioanalytical Chemistry
Volume	397
DOIs	https://doi.org/10.1007/s00216-010-3886-2
Publication status	Published - 2010

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title = "In-house validation of a liquid chromatography tandem mass spectrometry method for the analysis of lipophilic marine toxins in shellfish using matrix-matched calibration",

abstract = "A liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the quantitative analysis of lipophilic marine toxins in shellfish extracts (mussel, oyster, cockle and clam) was validated in-house using European Union (EU) Commission Decision 2002/657/EC as a guideline. The validation included the toxins okadaic acid (OA), yessotoxin (YTX), azaspiracid-1 (AZA1), pectenotoxin-2 (PTX2) and 13-desmethyl spirolide-C (SPX1). Validation was performed at 0.5, 1 and 1.5 times the current EU permitted levels, which are 160 μg kg",

author = "A. Gerssen and \{van Olst\}, E.H.W. and P.P.J. Mulder and \{de Boer\}, J.",

year = "2010",

doi = "10.1007/s00216-010-3886-2",

language = "English",

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In-house validation of a liquid chromatography tandem mass spectrometry method for the analysis of lipophilic marine toxins in shellfish using matrix-matched calibration. / Gerssen, A.; van Olst, E.H.W.; Mulder, P.P.J. et al.
In: Analytical and Bioanalytical Chemistry, Vol. 397, 2010, p. 3079-3088.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - In-house validation of a liquid chromatography tandem mass spectrometry method for the analysis of lipophilic marine toxins in shellfish using matrix-matched calibration

AU - Gerssen, A.

AU - van Olst, E.H.W.

AU - Mulder, P.P.J.

AU - de Boer, J.

PY - 2010

Y1 - 2010

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AB - A liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the quantitative analysis of lipophilic marine toxins in shellfish extracts (mussel, oyster, cockle and clam) was validated in-house using European Union (EU) Commission Decision 2002/657/EC as a guideline. The validation included the toxins okadaic acid (OA), yessotoxin (YTX), azaspiracid-1 (AZA1), pectenotoxin-2 (PTX2) and 13-desmethyl spirolide-C (SPX1). Validation was performed at 0.5, 1 and 1.5 times the current EU permitted levels, which are 160 μg kg

U2 - 10.1007/s00216-010-3886-2

DO - 10.1007/s00216-010-3886-2

M3 - Article

SN - 1618-2642

VL - 397

SP - 3079

EP - 3088

JO - Analytical and Bioanalytical Chemistry

JF - Analytical and Bioanalytical Chemistry

ER -

In-house validation of a liquid chromatography tandem mass spectrometry method for the analysis of lipophilic marine toxins in shellfish using matrix-matched calibration

Abstract

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