In vitro assay shows that PCB metabolites completely saturate thyroid hormone transport capacity in blood of wild polar bears (Ursus maritimus)

A.C. Gutleb; P.H. Cenijn; P. van Velzen; E. Lie; E. Ropstad; J.U. Skaare; T. Malmberg; A. Bergman; G. W. Gabrielsen; J. Legler

doi:10.1021/es903029j

In vitro assay shows that PCB metabolites completely saturate thyroid hormone transport capacity in blood of wild polar bears (Ursus maritimus)

A.C. Gutleb, P.H. Cenijn, P. van Velzen, E. Lie, E. Ropstad, J.U. Skaare, T. Malmberg, A. Bergman, G. W. Gabrielsen, J. Legler

Chemistry and Biology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Persistent chemicals accumulate in the arctic environment due to their chemical reactivity and physicochemical properties and polychlorinated biphenyls (PCBs) are the most concentrated pollutant class in polar bears (Ursus maritimus). Metabolism of PCB and polybrominated biphenyl ether (PBDE) flame-retardants alter their toxicological properties and these metabolites are known to interfere with the binding of thyroid hormone (TH) to transthyretin (TTR) in rodents and humans. In polar bear plasma samples no binding of [

Original language	English
Pages (from-to)	3149-3154
Journal	Environmental Science and Technology
Volume	44
Issue number	8
DOIs	https://doi.org/10.1021/es903029j
Publication status	Published - 2010

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(Table 1) Concentration of PCB and other contaminants in blood plasma of polar bears (Ursus maritimus) from Svalbard
Gutleb, A. C. (Contributor), Cenijn, P. H. (Contributor), van Velzen, M. (Contributor), Lie, E. (Contributor), Ropstad, E. (Contributor), Skaare, J. U. (Contributor), Malmberg, T. (Contributor), Bergman, Å. (Contributor), Gabrielsen, G. W. (Contributor) & Legler, J. (Contributor), Unknown Publisher, 18 Apr 2010
DOI: 10.1594/pangaea.810387, https://doi.pangaea.de/10.1594/PANGAEA.810387
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Gutleb, A. C., Cenijn, P. H., van Velzen, P., Lie, E., Ropstad, E., Skaare, J. U., Malmberg, T., Bergman, A., Gabrielsen, G. W., & Legler, J. (2010). In vitro assay shows that PCB metabolites completely saturate thyroid hormone transport capacity in blood of wild polar bears (Ursus maritimus). Environmental Science and Technology, 44(8), 3149-3154. https://doi.org/10.1021/es903029j

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abstract = "Persistent chemicals accumulate in the arctic environment due to their chemical reactivity and physicochemical properties and polychlorinated biphenyls (PCBs) are the most concentrated pollutant class in polar bears (Ursus maritimus). Metabolism of PCB and polybrominated biphenyl ether (PBDE) flame-retardants alter their toxicological properties and these metabolites are known to interfere with the binding of thyroid hormone (TH) to transthyretin (TTR) in rodents and humans. In polar bear plasma samples no binding of [",

author = "A.C. Gutleb and P.H. Cenijn and {van Velzen}, P. and E. Lie and E. Ropstad and J.U. Skaare and T. Malmberg and A. Bergman and Gabrielsen, {G. W.} and J. Legler",

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doi = "10.1021/es903029j",

language = "English",

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pages = "3149--3154",

journal = "Environmental Science and Technology",

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Gutleb, AC, Cenijn, PH, van Velzen, P, Lie, E, Ropstad, E, Skaare, JU, Malmberg, T, Bergman, A, Gabrielsen, GW & Legler, J 2010, 'In vitro assay shows that PCB metabolites completely saturate thyroid hormone transport capacity in blood of wild polar bears (Ursus maritimus)', Environmental Science and Technology, vol. 44, no. 8, pp. 3149-3154. https://doi.org/10.1021/es903029j

TY - JOUR

T1 - In vitro assay shows that PCB metabolites completely saturate thyroid hormone transport capacity in blood of wild polar bears (Ursus maritimus)

AU - Gutleb, A.C.

AU - Cenijn, P.H.

AU - van Velzen, P.

AU - Lie, E.

AU - Ropstad, E.

AU - Skaare, J.U.

AU - Malmberg, T.

AU - Bergman, A.

AU - Gabrielsen, G. W.

AU - Legler, J.

PY - 2010

Y1 - 2010

N2 - Persistent chemicals accumulate in the arctic environment due to their chemical reactivity and physicochemical properties and polychlorinated biphenyls (PCBs) are the most concentrated pollutant class in polar bears (Ursus maritimus). Metabolism of PCB and polybrominated biphenyl ether (PBDE) flame-retardants alter their toxicological properties and these metabolites are known to interfere with the binding of thyroid hormone (TH) to transthyretin (TTR) in rodents and humans. In polar bear plasma samples no binding of [

AB - Persistent chemicals accumulate in the arctic environment due to their chemical reactivity and physicochemical properties and polychlorinated biphenyls (PCBs) are the most concentrated pollutant class in polar bears (Ursus maritimus). Metabolism of PCB and polybrominated biphenyl ether (PBDE) flame-retardants alter their toxicological properties and these metabolites are known to interfere with the binding of thyroid hormone (TH) to transthyretin (TTR) in rodents and humans. In polar bear plasma samples no binding of [

U2 - 10.1021/es903029j

DO - 10.1021/es903029j

M3 - Article

VL - 44

SP - 3149

EP - 3154

JO - Environmental Science and Technology

JF - Environmental Science and Technology

SN - 0013-936X

IS - 8

ER -

In vitro assay shows that PCB metabolites completely saturate thyroid hormone transport capacity in blood of wild polar bears (Ursus maritimus)

Abstract

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Datasets

(Table 1) Concentration of PCB and other contaminants in blood plasma of polar bears (Ursus maritimus) from Svalbard

Cite this