Persistent chemicals accumulate in the arctic environment due to their chemical reactivity and physicochemical properties and polychlorinated biphenyls (PCBs) are the most concentrated pollutant class in polar bears (Ursus maritimus). Metabolism of PCB and polybrominated biphenyl ether (PBDE) flame-retardants alter their toxicological properties and these metabolites are known to interfere with the binding of thyroid hormone (TH) to transthyretin (TTR) in rodents and humans. In polar bear plasma samples no binding of [
|Journal||Environmental Science and Technology|
|Publication status||Published - 2010|
FingerprintDive into the research topics of 'In vitro assay shows that PCB metabolites completely saturate thyroid hormone transport capacity in blood of wild polar bears (Ursus maritimus)'. Together they form a unique fingerprint.
(Table 1) Concentration of PCB and other contaminants in blood plasma of polar bears (Ursus maritimus) from Svalbard
Gutleb, A. C. (Contributor), Cenijn, P. H. (Contributor), van Velzen, M. (Contributor), Lie, E. (Contributor), Ropstad, E. (Contributor), Skaare, J. U. (Contributor), Malmberg, T. (Contributor), Bergman, Å. (Contributor), Gabrielsen, G. W. (Contributor) & Legler, J. (Contributor), Unknown Publisher, 18 Apr 2010
DOI: 10.1594/pangaea.810387, https://doi.pangaea.de/10.1594/PANGAEA.810387