In vitro ovarian tumor growth and treatment response dynamics visualized with time-lapse OCT imaging

C. Evans, I. Rizvi, T. Hasan, J.F. de Boer

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Abstract

In vitro three-dimensional models for metastatic ovarian cancer have been useful for recapitulating the human disease. These spheroidal tumor cultures, however, can grow in excess of 1 mm in diameter, which are difficult to visualize without suitable imaging technology. Optical coherence tomography (OCT) is an ideal live imaging method for non-perturbatively visualizing these complex systems. OCT enabled detailed observations of the model at both nodular and cellular levels, revealing growth dynamics not previously observed. The development ofa time-lapse OCT system, capable of automated, multidimensional acquisition, further provided insights into the growth and chemotherapeutic response of ovarian cancer.© 2009 Optical Society of America.
Original languageEnglish
Pages (from-to)8892-8906
Number of pages15
JournalOptics Express
Volume17
Issue number11
DOIs
Publication statusPublished - 2009

Bibliographical note

In vitro ovarian tumor growth and treatment response dynamics visualized with time-lapse OCT imaging

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