In Vitro to In Vivo Relationships with Respect to Kidney Safety Biomarkers

Paul Jennings*

*Corresponding author for this work

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review


Human in vitro cell cultures from primary tissues, from cell line, or inducible pluripotent stem cells (iPSC) derived are extremely useful tools for further understanding human physiology and how cells react to chemical-induced cell stress. Renal cell cultures have been used very successfully to investigate the mechanisms of clinical nephrotoxins and nephrotoxic compounds found in the environment and in food. This is the major advantage of using in vitro cell cultures, as whole animal models are not very amenable to deep molecular investigation. The author investigates the potential of IL-19 to be detected in urine of patients with chronic kidney disease (CKD). Interleukin (IL)-19 is a novel biomarker of proximal tubule (PT) injury and a good example of a marker discovered in vitro with good translation as an in vivo biomarker. The use of normal, non-proliferating cells best reflects the situation of the nephron in vivo.

Original languageEnglish
Title of host publicationDrug Discovery Toxicology
Subtitle of host publicationFrom Target Assessment to Translational Biomarkers
Number of pages4
ISBN (Electronic)9781119053248
ISBN (Print)9781119053330
Publication statusPublished - 1 Jan 2016
Externally publishedYes


  • Chemical-induced cell stress
  • In vitro cell cultures
  • In vivo translation
  • Inducible pluripotent stem cells
  • Kidney safety biomarkers
  • Nephrotoxins
  • Renal cell lines


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