In vivo multifunctional optical coherence tomography at the periphery of the lungs

Fabio Feroldi, Joy Willemse, Valentina Davidoiu, Maximilian G. O. Gräfe, Dirck J. van Iperen, Annika W. M. Goorsenberg, Jouke T. Annema, Johannes M. A. Daniels, Peter I. Bonta, Johannes F. de Boer

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Remodeling of tissue, such as airway smooth muscle (ASM) and extracellular matrix, is considered a key feature of airways disease. No clinically accepted diagnostic method is currently available to assess airway remodeling or the effect of treatment modalities such as bronchial thermoplasty in asthma, other than invasive airway biopsies. Optical coherence tomography (OCT) generates cross-sectional, near-histological images of airway segments and enables identification and quantification of airway wall layers based on light scattering properties only. In this study, we used a custom motorized OCT probe that combines standard and polarization sensitive OCT (PS-OCT) to visualize birefringent tissue in vivo in the airway wall of a patient with severe asthma in a minimally invasive manner. We used optic axis uniformity (OAxU) to highlight the presence of uniformly arranged fiber-like tissue, helping visualizing the abundance of ASM and connective tissue structures. Attenuation coefficient images of the airways are presented for the first time, showing superior architectural contrast compared to standard OCT images. A novel segmentation algorithm was developed to detect the surface of the endoscope sheath and the surface of the tissue. PS-OCT is an innovative imaging technique that holds promise to assess airway remodeling including ASM and connective tissue in a minimally invasive, real-time manner.
Original languageEnglish
Pages (from-to)3070
JournalBiomedical Optics Express
Volume10
Issue number6
DOIs
Publication statusPublished - 1 Jun 2019

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Optical Coherence Tomography
smooth muscle
lungs
tomography
asthma
Airway Remodeling
Smooth Muscle
connective tissue
Lung
Connective Tissue
Asthma
Muscles
endoscopes
Endoscopes
attenuation coefficients
polarization
sheaths
imaging techniques
Extracellular Matrix
light scattering

Cite this

Feroldi, Fabio ; Willemse, Joy ; Davidoiu, Valentina ; Gräfe, Maximilian G. O. ; van Iperen, Dirck J. ; Goorsenberg, Annika W. M. ; Annema, Jouke T. ; Daniels, Johannes M. A. ; Bonta, Peter I. ; de Boer, Johannes F. / In vivo multifunctional optical coherence tomography at the periphery of the lungs. In: Biomedical Optics Express. 2019 ; Vol. 10, No. 6. pp. 3070.
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abstract = "Remodeling of tissue, such as airway smooth muscle (ASM) and extracellular matrix, is considered a key feature of airways disease. No clinically accepted diagnostic method is currently available to assess airway remodeling or the effect of treatment modalities such as bronchial thermoplasty in asthma, other than invasive airway biopsies. Optical coherence tomography (OCT) generates cross-sectional, near-histological images of airway segments and enables identification and quantification of airway wall layers based on light scattering properties only. In this study, we used a custom motorized OCT probe that combines standard and polarization sensitive OCT (PS-OCT) to visualize birefringent tissue in vivo in the airway wall of a patient with severe asthma in a minimally invasive manner. We used optic axis uniformity (OAxU) to highlight the presence of uniformly arranged fiber-like tissue, helping visualizing the abundance of ASM and connective tissue structures. Attenuation coefficient images of the airways are presented for the first time, showing superior architectural contrast compared to standard OCT images. A novel segmentation algorithm was developed to detect the surface of the endoscope sheath and the surface of the tissue. PS-OCT is an innovative imaging technique that holds promise to assess airway remodeling including ASM and connective tissue in a minimally invasive, real-time manner.",
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In vivo multifunctional optical coherence tomography at the periphery of the lungs. / Feroldi, Fabio; Willemse, Joy; Davidoiu, Valentina; Gräfe, Maximilian G. O.; van Iperen, Dirck J.; Goorsenberg, Annika W. M.; Annema, Jouke T.; Daniels, Johannes M. A.; Bonta, Peter I.; de Boer, Johannes F.

In: Biomedical Optics Express, Vol. 10, No. 6, 01.06.2019, p. 3070.

Research output: Contribution to JournalArticleAcademicpeer-review

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