Increased stability and breakdown of brain effective connectivity during slow-wave sleep: mechanistic insights from whole-brain computational modelling

B.M. Jobst, R. Hindriks, H. Laufs, E. Tagliazucchi, G. Hahn, A. Ponce-Alvarez, A.B.A. Stevner, M.L. Kringelbach, G. Deco

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Recent research has found that the human sleep cycle is characterised by changes in spatiotemporal patterns of brain activity. Yet, we are still missing a mechanistic explanation of the local neuronal dynamics underlying these changes. We used whole-brain computational modelling to study the differences in global brain functional connectivity and synchrony of fMRI activity in healthy humans during wakefulness and slow-wave sleep. We applied a whole-brain model based on the normal form of a supercritical Hopf bifurcation and studied the dynamical changes when adapting the bifurcation parameter for all brain nodes to best match wakefulness and slow-wave sleep. Furthermore, we analysed differences in effective connectivity between the two states. In addition to significant changes in functional connectivity, synchrony and metastability, this analysis revealed a significant shift of the global dynamic working point of brain dynamics, from the edge of the transition between damped to sustained oscillations during wakefulness, to a stable focus during slow-wave sleep. Moreover, we identified a significant global decrease in effective interactions during slow-wave sleep. These results suggest a mechanism for the empirical functional changes observed during slow-wave sleep, namely a global shift of the brain’s dynamic working point leading to increased stability and decreased effective connectivity.
LanguageEnglish
Article number4634
Pages1-16
Number of pages16
JournalScientific Reports
Volume7
DOIs
Publication statusPublished - 5 Jul 2017

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Sleep
Brain
Wakefulness
Magnetic Resonance Imaging
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Jobst, B.M. ; Hindriks, R. ; Laufs, H. ; Tagliazucchi, E. ; Hahn, G. ; Ponce-Alvarez, A. ; Stevner, A.B.A. ; Kringelbach, M.L. ; Deco, G. / Increased stability and breakdown of brain effective connectivity during slow-wave sleep: mechanistic insights from whole-brain computational modelling. In: Scientific Reports. 2017 ; Vol. 7. pp. 1-16.
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Increased stability and breakdown of brain effective connectivity during slow-wave sleep: mechanistic insights from whole-brain computational modelling. / Jobst, B.M.; Hindriks, R.; Laufs, H.; Tagliazucchi, E.; Hahn, G.; Ponce-Alvarez, A.; Stevner, A.B.A.; Kringelbach, M.L.; Deco, G.

In: Scientific Reports, Vol. 7, 4634, 05.07.2017, p. 1-16.

Research output: Contribution to JournalArticleAcademicpeer-review

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AU - Hahn, G.

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