Abstract
The extracellular space is occupied by a complex network of proteins creating a mesh-like assembly known as the extracellular matrix (ECM). ECM assembles into dense net-like structures, perineuronal nets (PNNs), that envelope cell somas and proximal neurites of predominantly parvalbumin+-(PV+) interneurons. ECM regulates cell-to-cell communication, thereby modulating neuronal network function. Accumulating evidence points to the importance of network dysfunction in the pathophysiology of psychiatric diseases, in which stress acts as a major predisposing factor. Here we review stress-induced changes in ECM/PNNs and PV+-interneurons in preclinical models of (or for) depression, with a special focus on social stress. We argue that the direction of these alterations largely depends on stress recency, as well as on stress timing and the brain region under investigation. A biphasic temporal regulation of ECM/PNNs and PV+-interneuron function is typically observed after stress. Understanding the complex mechanisms underlying ECM organization in relation to stress-induced molecular, cellular and network changes is crucial to further decipher the implications of ECM remodeling in the incubation of depressive symptoms.
Original language | English |
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Pages (from-to) | 65-79 |
Number of pages | 15 |
Journal | Neuroscience and Biobehavioral Reviews |
Volume | 118 |
DOIs | |
Publication status | Published - Nov 2020 |
Funding
MKK, DR, and SS were supported by an NWO VICI grant ( ALW-Vici 016.150.673 / 865.14.002 ); DR was supported by the E U Research and Innovation Framework Programme Horizon 2020: Marie Skłodowska Curie Actions , Individual Fellowship (MSCA-IF-EF-ST; 793106 ).
Funders | Funder number |
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MSCA-IF-EF-ST | 793106 |
Nederlandse Organisatie voor Wetenschappelijk Onderzoek | ALW-Vici 016.150.673 / 865.14.002 |
Horizon 2020 |
Keywords
- Chronic mild/unpredictable stress
- Early life stress
- Experience-dependent plasticity
- Hippocampus
- Hyper-excitability
- Hypo-excitability
- Prefrontal cortex
- Restraint stress
- Social defeat stress