Infant colic: mechanisms and management

Judith Zeevenhooven*, Pamela D. Browne, Monique P. L’Hoir, Carolina de Weerth, Marc A. Benninga

*Corresponding author for this work

Research output: Contribution to JournalReview articleAcademicpeer-review


Infant colic is a commonly reported phenomenon of excessive crying in infancy with an enigmatic and distressing character. Despite its frequent occurrence, little agreement has been reached on the definition, pathogenesis or the optimal management strategy for infant colic. This Review aims to delineate the definitional entanglement with the Rome IV criteria, which were published in 2016, as the leading, most recent diagnostic criteria. Moreover, neurogenic, gastrointestinal, microbial and psychosocial factors that might contribute to the pathophysiology of infant colic are explored. This Review underlines that a comprehensive medical history and physical examination in the absence of alarm symptoms serve as guidance for the clinician to a positive diagnosis. It also highlights that an important aspect of the management of infant colic is parental education and reassurance. Management strategies, including behavioural, dietary, pharmacological and alternative interventions, are also discussed. Owing to a lack of large, high-quality randomized controlled trials, none of these therapies are strongly recommended. Finally, the behavioural and somatic sequelae of infant colic into childhood are summarized.

Original languageEnglish
Pages (from-to)479-496
Number of pages18
JournalNature Reviews Gastroenterology and Hepatology
Issue number8
Publication statusPublished - 1 Aug 2018


Dive into the research topics of 'Infant colic: mechanisms and management'. Together they form a unique fingerprint.

Cite this