Inference of the Genetic Architecture Underlying BMI and Height with the Use of 20,240 Sibling Pairs

G. Hemani; J. Yang; A.A.E. Vinkhuyzen; J.E. Powell; G. Willemsen; J.J. Hottenga; A. Abdellaoui; M. Mangino; A.M. Valdes; S.E. Medland; P.A.F. Madden; A.C. Heath; A.K. Henders; DR Nyholt; E.J.C. de Geus; P.K.E. Magnusson; E. Ingelsson; G.W. Montgomery; T.D. Spector; D.I. Boomsma; N.L. Pedersen; N.G. Martin; P.M. Visscher

doi:10.1016/j.ajhg.2013.10.005

Inference of the Genetic Architecture Underlying BMI and Height with the Use of 20,240 Sibling Pairs

G. Hemani, J. Yang, A.A.E. Vinkhuyzen, J.E. Powell, G. Willemsen, J.J. Hottenga, A. Abdellaoui, M. Mangino, A.M. Valdes, S.E. Medland, P.A.F. Madden, A.C. Heath, A.K. Henders, DR Nyholt, E.J.C. de Geus, P.K.E. Magnusson, E. Ingelsson, G.W. Montgomery, T.D. Spector, D.I. BoomsmaN.L. Pedersen, N.G. Martin, P.M. Visscher

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Evidence that complex traits are highly polygenic has been presented by population-based genome-wide association studies (GWASs) through the identification of many significant variants, as well as by family-based de novo sequencing studies indicating that several traits have a large mutational target size. Here, using a third study design, we show results consistent with extreme polygenicity for body mass index (BMI) and height. On a sample of 20,240 siblings (from 9,570 nuclear families), we used a within-family method to obtain narrow-sense heritability estimates of 0.42 (SE = 0.17, p = 0.01) and 0.69 (SE = 0.14, p = 6 × 10

Original language	English
Pages (from-to)	865-875
Journal	American Journal of Human Genetics
Volume	93
Issue number	5
Early online date	31 Oct 2013
DOIs	https://doi.org/10.1016/j.ajhg.2013.10.005
Publication status	Published - 2013

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Hemani, G., Yang, J., Vinkhuyzen, A. A. E., Powell, J. E., Willemsen, G., Hottenga, J. J., Abdellaoui, A., Mangino, M., Valdes, A. M., Medland, S. E., Madden, P. A. F., Heath, A. C., Henders, A. K., Nyholt, DR., de Geus, E. J. C., Magnusson, P. K. E., Ingelsson, E., Montgomery, G. W., Spector, T. D., ... Visscher, P. M. (2013). Inference of the Genetic Architecture Underlying BMI and Height with the Use of 20,240 Sibling Pairs. American Journal of Human Genetics, 93(5), 865-875. https://doi.org/10.1016/j.ajhg.2013.10.005

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title = "Inference of the Genetic Architecture Underlying BMI and Height with the Use of 20,240 Sibling Pairs",

abstract = "Evidence that complex traits are highly polygenic has been presented by population-based genome-wide association studies (GWASs) through the identification of many significant variants, as well as by family-based de novo sequencing studies indicating that several traits have a large mutational target size. Here, using a third study design, we show results consistent with extreme polygenicity for body mass index (BMI) and height. On a sample of 20,240 siblings (from 9,570 nuclear families), we used a within-family method to obtain narrow-sense heritability estimates of 0.42 (SE = 0.17, p = 0.01) and 0.69 (SE = 0.14, p = 6 × 10",

author = "G. Hemani and J. Yang and A.A.E. Vinkhuyzen and J.E. Powell and G. Willemsen and J.J. Hottenga and A. Abdellaoui and M. Mangino and A.M. Valdes and S.E. Medland and P.A.F. Madden and A.C. Heath and A.K. Henders and DR Nyholt and {de Geus}, E.J.C. and P.K.E. Magnusson and E. Ingelsson and G.W. Montgomery and T.D. Spector and D.I. Boomsma and N.L. Pedersen and N.G. Martin and P.M. Visscher",

year = "2013",

doi = "10.1016/j.ajhg.2013.10.005",

language = "English",

volume = "93",

pages = "865--875",

journal = "American Journal of Human Genetics",

issn = "0002-9297",

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Hemani, G, Yang, J, Vinkhuyzen, AAE, Powell, JE, Willemsen, G, Hottenga, JJ, Abdellaoui, A, Mangino, M, Valdes, AM, Medland, SE, Madden, PAF, Heath, AC, Henders, AK, Nyholt, DR, de Geus, EJC, Magnusson, PKE, Ingelsson, E, Montgomery, GW, Spector, TD, Boomsma, DI, Pedersen, NL, Martin, NG & Visscher, PM 2013, 'Inference of the Genetic Architecture Underlying BMI and Height with the Use of 20,240 Sibling Pairs', American Journal of Human Genetics, vol. 93, no. 5, pp. 865-875. https://doi.org/10.1016/j.ajhg.2013.10.005

TY - JOUR

T1 - Inference of the Genetic Architecture Underlying BMI and Height with the Use of 20,240 Sibling Pairs

AU - Hemani, G.

AU - Yang, J.

AU - Vinkhuyzen, A.A.E.

AU - Powell, J.E.

AU - Willemsen, G.

AU - Hottenga, J.J.

AU - Abdellaoui, A.

AU - Mangino, M.

AU - Valdes, A.M.

AU - Medland, S.E.

AU - Madden, P.A.F.

AU - Heath, A.C.

AU - Henders, A.K.

AU - Nyholt, DR

AU - de Geus, E.J.C.

AU - Magnusson, P.K.E.

AU - Ingelsson, E.

AU - Montgomery, G.W.

AU - Spector, T.D.

AU - Boomsma, D.I.

AU - Pedersen, N.L.

AU - Martin, N.G.

AU - Visscher, P.M.

PY - 2013

Y1 - 2013

N2 - Evidence that complex traits are highly polygenic has been presented by population-based genome-wide association studies (GWASs) through the identification of many significant variants, as well as by family-based de novo sequencing studies indicating that several traits have a large mutational target size. Here, using a third study design, we show results consistent with extreme polygenicity for body mass index (BMI) and height. On a sample of 20,240 siblings (from 9,570 nuclear families), we used a within-family method to obtain narrow-sense heritability estimates of 0.42 (SE = 0.17, p = 0.01) and 0.69 (SE = 0.14, p = 6 × 10

AB - Evidence that complex traits are highly polygenic has been presented by population-based genome-wide association studies (GWASs) through the identification of many significant variants, as well as by family-based de novo sequencing studies indicating that several traits have a large mutational target size. Here, using a third study design, we show results consistent with extreme polygenicity for body mass index (BMI) and height. On a sample of 20,240 siblings (from 9,570 nuclear families), we used a within-family method to obtain narrow-sense heritability estimates of 0.42 (SE = 0.17, p = 0.01) and 0.69 (SE = 0.14, p = 6 × 10

U2 - 10.1016/j.ajhg.2013.10.005

DO - 10.1016/j.ajhg.2013.10.005

M3 - Article

SN - 0002-9297

VL - 93

SP - 865

EP - 875

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 5

ER -

Inference of the Genetic Architecture Underlying BMI and Height with the Use of 20,240 Sibling Pairs

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