Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism

P.H.J. Keizers; B.M.A. Lussenburg; C. de Graaf; L.M. Mentink; N.P.E. Vermeulen; J.N.M. Commandeur

doi:10.1016/j.bcp.2004.08.013

Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism

P.H.J. Keizers, B.M.A. Lussenburg, C. de Graaf, L.M. Mentink, N.P.E. Vermeulen, J.N.M. Commandeur

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The polymorphic human debrisoquine hydroxylase, cytochrome P450 2D6 (CYP2D6), is one of the most important phase I drug metabolising enzymes. It is responsible for metabolising a large number of compounds that mostly share similarity in having a basic N-atom and an aromatic moiety. In homology modelling studies, it has been suggested that in fixation of this aromatic moiety, there may be an important role for phenylalanine 120 (Phe

Original language	English
Pages (from-to)	2263-71
Journal	Biochemical Pharmacology
Volume	68
Issue number	11
DOIs	https://doi.org/10.1016/j.bcp.2004.08.013
Publication status	Published - 2004

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title = "Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism",

abstract = "The polymorphic human debrisoquine hydroxylase, cytochrome P450 2D6 (CYP2D6), is one of the most important phase I drug metabolising enzymes. It is responsible for metabolising a large number of compounds that mostly share similarity in having a basic N-atom and an aromatic moiety. In homology modelling studies, it has been suggested that in fixation of this aromatic moiety, there may be an important role for phenylalanine 120 (Phe",

author = "P.H.J. Keizers and B.M.A. Lussenburg and {de Graaf}, C. and L.M. Mentink and N.P.E. Vermeulen and J.N.M. Commandeur",

year = "2004",

doi = "10.1016/j.bcp.2004.08.013",

language = "English",

volume = "68",

pages = "2263--71",

journal = "Biochemical Pharmacology",

issn = "0006-2952",

publisher = "Elsevier Inc.",

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T1 - Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism

AU - Keizers, P.H.J.

AU - Lussenburg, B.M.A.

AU - de Graaf, C.

AU - Mentink, L.M.

AU - Vermeulen, N.P.E.

AU - Commandeur, J.N.M.

PY - 2004

Y1 - 2004

N2 - The polymorphic human debrisoquine hydroxylase, cytochrome P450 2D6 (CYP2D6), is one of the most important phase I drug metabolising enzymes. It is responsible for metabolising a large number of compounds that mostly share similarity in having a basic N-atom and an aromatic moiety. In homology modelling studies, it has been suggested that in fixation of this aromatic moiety, there may be an important role for phenylalanine 120 (Phe

AB - The polymorphic human debrisoquine hydroxylase, cytochrome P450 2D6 (CYP2D6), is one of the most important phase I drug metabolising enzymes. It is responsible for metabolising a large number of compounds that mostly share similarity in having a basic N-atom and an aromatic moiety. In homology modelling studies, it has been suggested that in fixation of this aromatic moiety, there may be an important role for phenylalanine 120 (Phe

U2 - 10.1016/j.bcp.2004.08.013

DO - 10.1016/j.bcp.2004.08.013

M3 - Article

VL - 68

SP - 2263

EP - 2271

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

SN - 0006-2952

IS - 11

ER -

Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism

Abstract

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