Inhalation exposure to 1,3-dichloropropene in the Dutch flower-bulb culture. Part II. Biological monitoring by measurement of urinary excretion of two mercapturic acid metabolites

R.T.H. van Welie, P van Duyn, D H Brouwer, J J van Hemmen, E J Brouwer, N P Vermeulen

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

A biological monitoring study was carried out in the Dutch flower-bulb culture to determine the relationship between respiratory occupational exposure to Z- and E-1,3-dichloropropene (Z- and E-DCP) and urinary excretion of two mercapturic acid metabolites, N-acetyl-S-(Z- and E-3-chloropropenyl-2)-L- cysteine (Z- and E-DCP-MA). Urinary excretion of Z- and E-DCP-MA, either based on excretion rates or on creatinine excretion, followed first order elimination kinetics after exposure. Urinary half-lives of elimination were 5.0 +/- 1.2 hr for Z-DCP-MA and 4.7 +/- 1.3 hr for E-DCP-MA and were not statistically significantly different. Calculated coefficients of variation indicated that the half-lives of elimination of Z- and E-DCP-MA were quite consistent inter- and intra-individually. Strong correlations (r greater than or equal to 0.93) were observed between respiratory 8-hr time weighted average (TWA) exposure to Z- and E-DCP and complete cumulative urinary excretion of Z- and E-DCP-MA. Z-DCP yielded three times more mercapturic acid than E-DCP, probably due to differences in metabolism. Z- and E-DCP were excreted 45 and 14% as their respective mercapturic acid metabolites. A respiratory 8-hr TWA exposure to the Dutch occupational exposure limit of 5 mg.m-3 DCP would result in a complete cumulative excretion of 14.4 mg (95% confidence interval: 11.7-17.0 mg) Z-DCP-MA and 3.2 mg (95% confidence interval: 2.3-4.1 mg) E-DCP-MA.

Original languageEnglish
Pages (from-to)6-12
Number of pages7
JournalArchives of Environmental Contamination and Toxicology
Volume20
Issue number1
DOIs
Publication statusPublished - Jan 1991

Keywords

  • Adult
  • Agriculture
  • Air Pollutants, Occupational
  • Allyl Compounds
  • Environmental Exposure
  • Half-Life
  • Humans
  • Hydrocarbons, Chlorinated
  • Insecticides
  • Male
  • Middle Aged
  • Netherlands
  • Journal Article
  • Research Support, Non-U.S. Gov't

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