Inhibition of G Protein–Coupled Receptor Kinase 2 Promotes Unbiased Downregulation of IGF1 Receptor and Restrains Malignant Cell Growth

Caitrin Crudden, Takashi Shibano, Dawei Song, Mihnea P. Dragomir, Sonia Cismas, Julianna Serly, Daniela Nedelcu, Enrique Fuentes-Mattei, Andrei Tica, George A. Calin, Ada Girnita, Leonard Girnita

Research output: Contribution to JournalArticleAcademicpeer-review

Original languageUndefined/Unknown
Pages (from-to)501-515
JournalCancer Research
Volume81
Issue number2
DOIs
Publication statusPublished - 15 Jan 2021

Funding

C. Crudden reports grants from European Commission outside the submitted work. No disclosures were reported by the other authors. We thank Drs. R.J. Lefkowitz, R. Baserga, and V. Gurivech for generously providing reagents and cell lines. We thank Anna Malmerfelt at the histology core facility, Karolinska Institutet, for technical assistance. Research support was received from the Swedish Research Council, Swedish Cancer Society, The Swedish Childhood Cancer Foundation, Crown Princess Margareta’s Foundation for the Visually Impaired, Welander Finsen Foundation, King Gustaf V Jubilee Foundation, SINF StratCan, Stockholm Cancer Society, Stockholm County, and Karolinska Institute. Dr. G.A. Calin is the Felix L. Haas Endowed Professor in Basic Science. Work in Dr. G.A. Calin’s laboratory is supported by NIH (NIH/NCATS) grant UH3TR00943–01 through the NIH Common Fund, Office of Strategic Coordination (OSC), the NCI grants 1R01 CA182905–01 and 1R01CA222007–01A1, an NIGMS 1R01GM122775–01 grant, a U54 grant #CA096297/CA096300—UPR/MDACC Partnership for Excellence in Cancer Research 2016 Pilot Project, a Team DOD (CA160445P1) grant, a Chronic Lymphocytic Leukemia Moonshot Flagship project, a CLL Global Research Foundation 2019 grant, a CLL Global Research Foundation 2020 grant, and the Estate of C.G. Johnson, Jr.

FundersFunder number
Crown Princess Margareta’s Foundation
SINF StratCan
Team DODCA160445P1
Welander Finsen Foundation
National Institutes of Health
National Cancer Institute1R01CA222007–01A1, 1R01 CA182905–01, U54CA096300
National Institute of General Medical Sciences1R01GM122775–01
CLL Global Research Foundation
National Center for Advancing Translational SciencesUH3TR00943–01
Cancerfonden
Karolinska Institutet
Vetenskapsrådet
Barncancerfonden
Stiftelsen Konung Gustaf V:s Jubileumsfond
Cancerföreningen i Stockholm

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