Injury Markers but not Amyloid Markers are Associated with Rapid Progression from Mild Cognitive Impairment to Dementia in Alzheimer's Disease

I.A. van Rossum; P.J. Visser; D.L. Knol; W.M. van der Flier; C.E. Teunissen; F. Barkhof; M.A. Blankenstein; P. Scheltens

doi:10.3233/JAD-2011-111694

Injury Markers but not Amyloid Markers are Associated with Rapid Progression from Mild Cognitive Impairment to Dementia in Alzheimer's Disease

I.A. van Rossum, P.J. Visser, D.L. Knol, W.M. van der Flier, C.E. Teunissen, F. Barkhof, M.A. Blankenstein, P. Scheltens

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Alzheimer's disease (AD) is a common cause of mild cognitive impairment (MCI). However, the time between the diagnosis of MCI and the diagnosis of dementia is highly variable. In this study we investigated which known risk factors and biomarkers of AD pathology were associated with rapid progression from MCI to dementia. Of the 203 subjects with MCI, 91 progressed to AD-type dementia and were considered to have MCI-AD at baseline. Subjects with MCI-AD were older, more frequently female and carrier of the APOE-ε4 allele, had lower scores on the Mini-Mental State Examination (MMSE), more medial temporal lobe atrophy (MTA) and lower levels of Aβ

Original language	English
Pages (from-to)	319-327
Journal	Journal of Alzheimer's Disease
Volume	29
Issue number	2
DOIs	https://doi.org/10.3233/JAD-2011-111694
Publication status	Published - 2012

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van Rossum, I. A., Visser, P. J., Knol, D. L., van der Flier, W. M., Teunissen, C. E., Barkhof, F., Blankenstein, M. A., & Scheltens, P. (2012). Injury Markers but not Amyloid Markers are Associated with Rapid Progression from Mild Cognitive Impairment to Dementia in Alzheimer's Disease. Journal of Alzheimer's Disease, 29(2), 319-327. https://doi.org/10.3233/JAD-2011-111694

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title = "Injury Markers but not Amyloid Markers are Associated with Rapid Progression from Mild Cognitive Impairment to Dementia in Alzheimer's Disease",

abstract = "Alzheimer's disease (AD) is a common cause of mild cognitive impairment (MCI). However, the time between the diagnosis of MCI and the diagnosis of dementia is highly variable. In this study we investigated which known risk factors and biomarkers of AD pathology were associated with rapid progression from MCI to dementia. Of the 203 subjects with MCI, 91 progressed to AD-type dementia and were considered to have MCI-AD at baseline. Subjects with MCI-AD were older, more frequently female and carrier of the APOE-ε4 allele, had lower scores on the Mini-Mental State Examination (MMSE), more medial temporal lobe atrophy (MTA) and lower levels of Aβ",

author = "{van Rossum}, I.A. and P.J. Visser and D.L. Knol and {van der Flier}, W.M. and C.E. Teunissen and F. Barkhof and M.A. Blankenstein and P. Scheltens",

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doi = "10.3233/JAD-2011-111694",

language = "English",

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T1 - Injury Markers but not Amyloid Markers are Associated with Rapid Progression from Mild Cognitive Impairment to Dementia in Alzheimer's Disease

AU - van Rossum, I.A.

AU - Visser, P.J.

AU - Knol, D.L.

AU - van der Flier, W.M.

AU - Teunissen, C.E.

AU - Barkhof, F.

AU - Blankenstein, M.A.

AU - Scheltens, P.

PY - 2012

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N2 - Alzheimer's disease (AD) is a common cause of mild cognitive impairment (MCI). However, the time between the diagnosis of MCI and the diagnosis of dementia is highly variable. In this study we investigated which known risk factors and biomarkers of AD pathology were associated with rapid progression from MCI to dementia. Of the 203 subjects with MCI, 91 progressed to AD-type dementia and were considered to have MCI-AD at baseline. Subjects with MCI-AD were older, more frequently female and carrier of the APOE-ε4 allele, had lower scores on the Mini-Mental State Examination (MMSE), more medial temporal lobe atrophy (MTA) and lower levels of Aβ

AB - Alzheimer's disease (AD) is a common cause of mild cognitive impairment (MCI). However, the time between the diagnosis of MCI and the diagnosis of dementia is highly variable. In this study we investigated which known risk factors and biomarkers of AD pathology were associated with rapid progression from MCI to dementia. Of the 203 subjects with MCI, 91 progressed to AD-type dementia and were considered to have MCI-AD at baseline. Subjects with MCI-AD were older, more frequently female and carrier of the APOE-ε4 allele, had lower scores on the Mini-Mental State Examination (MMSE), more medial temporal lobe atrophy (MTA) and lower levels of Aβ

U2 - 10.3233/JAD-2011-111694

DO - 10.3233/JAD-2011-111694

M3 - Article

SN - 1387-2877

VL - 29

SP - 319

EP - 327

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

IS - 2

ER -

Injury Markers but not Amyloid Markers are Associated with Rapid Progression from Mild Cognitive Impairment to Dementia in Alzheimer's Disease

Abstract

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