Injury markers predict time to dementia in subjects with MCI and amyloid pathology

I.A. van Rossum; S.J.B. Vos; L. Burns; D.L. Knol; P. Scheltens; H. Soininen; L.O. Wahlund; H. Hampel; M. Tsolaki; L. Minthon; G. L'Italien; W.M. van der Flier; C.E. Teunissen; K. Blennow; F. Barkhof; D. Rueckert; R. Wolz; F. Verhey; P.J. Visser

doi:10.1212/WNL.0b013e3182704056

Injury markers predict time to dementia in subjects with MCI and amyloid pathology

I.A. van Rossum, S.J.B. Vos, L. Burns, D.L. Knol, P. Scheltens, H. Soininen, L.O. Wahlund, H. Hampel, M. Tsolaki, L. Minthon, G. L'Italien, W.M. van der Flier, C.E. Teunissen, K. Blennow, F. Barkhof, D. Rueckert, R. Wolz, F. Verhey, P.J. Visser

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Abstract

Objectives: Alzheimer disease (AD) can now be diagnosed in subjects with mild cognitive impairment (MCI) using biomarkers. However, little is known about the rate of decline in those subjects. In this cohort study, we aimed to assess the conversion rate to dementia and identify prognostic markers in subjects with MCI and evidence of amyloid pathology. Methods: We pooled subjects from the VU University Medical Center Alzheimer Center and the Development of Screening Guidelines and Criteria for Predementia Alzheimer's Disease (DESCRIPA) study. We included subjects with MCI, an abnormal level of β-amyloid

Original language	English
Pages (from-to)	1809-1816
Journal	Neurology
Volume	79
Issue number	17
DOIs	https://doi.org/10.1212/WNL.0b013e3182704056
Publication status	Published - 2012

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van Rossum, I. A., Vos, S. J. B., Burns, L., Knol, D. L., Scheltens, P., Soininen, H., Wahlund, L. O., Hampel, H., Tsolaki, M., Minthon, L., L'Italien, G., van der Flier, W. M., Teunissen, C. E., Blennow, K., Barkhof, F., Rueckert, D., Wolz, R., Verhey, F., & Visser, P. J. (2012). Injury markers predict time to dementia in subjects with MCI and amyloid pathology. Neurology, 79(17), 1809-1816. https://doi.org/10.1212/WNL.0b013e3182704056

@article{17c68b7ae32c498fb628ca03a3b9e837,

title = "Injury markers predict time to dementia in subjects with MCI and amyloid pathology",

abstract = "Objectives: Alzheimer disease (AD) can now be diagnosed in subjects with mild cognitive impairment (MCI) using biomarkers. However, little is known about the rate of decline in those subjects. In this cohort study, we aimed to assess the conversion rate to dementia and identify prognostic markers in subjects with MCI and evidence of amyloid pathology. Methods: We pooled subjects from the VU University Medical Center Alzheimer Center and the Development of Screening Guidelines and Criteria for Predementia Alzheimer's Disease (DESCRIPA) study. We included subjects with MCI, an abnormal level of β-amyloid",

author = "{van Rossum}, I.A. and S.J.B. Vos and L. Burns and D.L. Knol and P. Scheltens and H. Soininen and L.O. Wahlund and H. Hampel and M. Tsolaki and L. Minthon and G. L'Italien and {van der Flier}, W.M. and C.E. Teunissen and K. Blennow and F. Barkhof and D. Rueckert and R. Wolz and F. Verhey and P.J. Visser",

year = "2012",

doi = "10.1212/WNL.0b013e3182704056",

language = "English",

volume = "79",

pages = "1809--1816",

journal = "Neurology",

issn = "0028-3878",

publisher = "American Academy of Neurology",

number = "17",

}

van Rossum, IA, Vos, SJB, Burns, L, Knol, DL, Scheltens, P, Soininen, H, Wahlund, LO, Hampel, H, Tsolaki, M, Minthon, L, L'Italien, G, van der Flier, WM, Teunissen, CE, Blennow, K, Barkhof, F, Rueckert, D, Wolz, R, Verhey, F & Visser, PJ 2012, 'Injury markers predict time to dementia in subjects with MCI and amyloid pathology', Neurology, vol. 79, no. 17, pp. 1809-1816. https://doi.org/10.1212/WNL.0b013e3182704056

TY - JOUR

T1 - Injury markers predict time to dementia in subjects with MCI and amyloid pathology

AU - van Rossum, I.A.

AU - Vos, S.J.B.

AU - Burns, L.

AU - Knol, D.L.

AU - Scheltens, P.

AU - Soininen, H.

AU - Wahlund, L.O.

AU - Hampel, H.

AU - Tsolaki, M.

AU - Minthon, L.

AU - L'Italien, G.

AU - van der Flier, W.M.

AU - Teunissen, C.E.

AU - Blennow, K.

AU - Barkhof, F.

AU - Rueckert, D.

AU - Wolz, R.

AU - Verhey, F.

AU - Visser, P.J.

PY - 2012

Y1 - 2012

N2 - Objectives: Alzheimer disease (AD) can now be diagnosed in subjects with mild cognitive impairment (MCI) using biomarkers. However, little is known about the rate of decline in those subjects. In this cohort study, we aimed to assess the conversion rate to dementia and identify prognostic markers in subjects with MCI and evidence of amyloid pathology. Methods: We pooled subjects from the VU University Medical Center Alzheimer Center and the Development of Screening Guidelines and Criteria for Predementia Alzheimer's Disease (DESCRIPA) study. We included subjects with MCI, an abnormal level of β-amyloid

AB - Objectives: Alzheimer disease (AD) can now be diagnosed in subjects with mild cognitive impairment (MCI) using biomarkers. However, little is known about the rate of decline in those subjects. In this cohort study, we aimed to assess the conversion rate to dementia and identify prognostic markers in subjects with MCI and evidence of amyloid pathology. Methods: We pooled subjects from the VU University Medical Center Alzheimer Center and the Development of Screening Guidelines and Criteria for Predementia Alzheimer's Disease (DESCRIPA) study. We included subjects with MCI, an abnormal level of β-amyloid

U2 - 10.1212/WNL.0b013e3182704056

DO - 10.1212/WNL.0b013e3182704056

M3 - Article

SN - 0028-3878

VL - 79

SP - 1809

EP - 1816

JO - Neurology

JF - Neurology

IS - 17

ER -

Injury markers predict time to dementia in subjects with MCI and amyloid pathology

Abstract

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