Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment

Žiga Tkalec; Jean Philippe Antignac; Nicole Bandow; Frederic M. Béen; Lidia Belova; Jos Bessems; Bruno Le Bizec; Werner Brack; German Cano-Sancho; Jade Chaker; Adrian Covaci; Nicolas Creusot; Arthur David; Laurent Debrauwer; Gaud Dervilly; Radu Corneliu Duca; Valérie Fessard; Joan O. Grimalt; Thierry Guerin; Baninia Habchi; Helge Hecht; Juliane Hollender; Emilien L. Jamin; Jana Klánová; Tina Kosjek; Martin Krauss; Marja Lamoree; Gwenaelle Lavison-Bompard; Jeroen Meijer; Ruth Moeller; Hans Mol; Sophie Mompelat; An Van Nieuwenhuyse; Herbert Oberacher; Julien Parinet; Christof Van Poucke; Robert Roškar; Anne Togola; Jurij Trontelj; Elliott J. Price

doi:10.1016/j.envint.2024.108585

Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment

Žiga Tkalec, Jean Philippe Antignac, Nicole Bandow, Frederic M. Béen, Lidia Belova, Jos Bessems, Bruno Le Bizec, Werner Brack, German Cano-Sancho, Jade Chaker, Adrian Covaci, Nicolas Creusot, Arthur David, Laurent Debrauwer, Gaud Dervilly, Radu Corneliu Duca, Valérie Fessard, Joan O. Grimalt, Thierry Guerin, Baninia HabchiHelge Hecht, Juliane Hollender, Emilien L. Jamin, Jana Klánová, Tina Kosjek, Martin Krauss, Marja Lamoree, Gwenaelle Lavison-Bompard, Jeroen Meijer, Ruth Moeller, Hans Mol, Sophie Mompelat, An Van Nieuwenhuyse, Herbert Oberacher, Julien Parinet, Christof Van Poucke, Robert Roškar, Anne Togola, Jurij Trontelj, Elliott J. Price^*

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The chemical burden on the environment and human population is increasing. Consequently, regulatory risk assessment must keep pace to manage, reduce, and prevent adverse impacts on human and environmental health associated with hazardous chemicals. Surveillance of chemicals of known, emerging, or potential future concern, entering the environment-food-human continuum is needed to document the reality of risks posed by chemicals on ecosystem and human health from a one health perspective, feed into early warning systems and support public policies for exposure mitigation provisions and safe and sustainable by design strategies. The use of less-conventional sampling strategies and integration of full-scan, high-resolution mass spectrometry and effect-directed analysis in environmental and human monitoring programmes have the potential to enhance the screening and identification of a wider range of chemicals of known, emerging or potential future concern. Here, we outline the key needs and recommendations identified within the European Partnership for Assessment of Risks from Chemicals (PARC) project for leveraging these innovative methodologies to support the development of next-generation chemical risk assessment.

Original language	English
Article number	108585
Pages (from-to)	1-16
Number of pages	16
Journal	Environment International
Volume	186
Early online date	17 Mar 2024
DOIs	https://doi.org/10.1016/j.envint.2024.108585
Publication status	Published - Apr 2024

Bibliographical note

Publisher Copyright:
© 2024

Funding

This project was co-funded from the Horizon Europe programme under grant agreement 101057014 (PARC). \u017DT, HH, JK and EJP acknowledge the research infrastructure RECETOX RI (LM2023069), the support from European Union's Horizon 2020 research and innovation program under grant agreement No 857560 (CETOCOEN Excellence) and OP RDE (CZ.02.1.01/0.0/0.0/17_043/0009632) and CETOCOEN PLUS (CZ.02.1.01/0.0/0.0/15_003/0000469). LB acknowledges funding through Research Foundation Flanders (FWO) fellowship (11G1821N). AC acknowledges the FWO research infrastructure EIRENE-Flanders (FWO I001923N) and the Exposome Centre of Excellence of the University of Antwerp (BOF grant, Antigoon database number 41222). The authors kindly thank Karl Lilja, Anja Duffek, Christophe Rousselle and Lutz Ahrens for their comments and suggestions during manuscript preparation. Views and opinions expressed are those of the author(s) only and do not necessarily reflect those of the European Union or the granting authority, European Health and Digital Executive Agency (HADEA). Neither the European Union nor the granting authority can be held responsible for any use that may be made of the information it contains. This research was co-funded from the European Union\u2019s Horizon Europe project PARC ( 101057014 ). \u017DT, HH, JK and EJP acknowledge the research infrastructure RECETOX RI (LM2023069), H2020 CETOCOEN Excellence 857560 and OP RDE CZ.02.1.01/0.0/0.0/17_043/0009632) and CETOCOEN PLUS CZ.02.1.01/0.0/0.0/15_003/0000469). LB acknowledges funding through Research Foundation Flanders (FWO) fellowship ( 11G1821N ). AC acknowledges the FWO research infrastructure EIRENE-Flanders (FWO I001923N) and the Exposome Centre of Excellence of the University of Antwerp (BOF grant, Antigoon database number 41222). This publication reflects only the authors\u2019 views, and the European Commission is not responsible for any use that may be made of the information it contains. The authors kindly thank Karl Lilja, Anja Duffek, Christophe Rousselle and Lutz Ahrens for their comments and suggestions during manuscript preparation.

Funders	Funder number
European Health and Digital Executive Agency
European Commission
Exposome Centre of Excellence of the University of Antwerp	41222
HORIZON EUROPE Framework Programme	101057014
Horizon 2020	CZ.02.1.01/0.0/0.0/15_003/0000469
Pakistan Agricultural Research Council	LM2023069
Horizon 2020 Framework Programme	857560
Fonds Wetenschappelijk Onderzoek	11G1821N
European Union’s Horizon Europe project PARC	101057014

Keywords

Chemical exposure
Chemical risk assessment
Effect-based methods
Effect-directed analysis
High-resolution mass spectrometry
Sampling strategies

Access to Document

10.1016/j.envint.2024.108585

Persistent URL (handle)

Persistent link

Cite this

Tkalec, Ž., Antignac, J. P., Bandow, N., Béen, F. M., Belova, L., Bessems, J., Le Bizec, B., Brack, W., Cano-Sancho, G., Chaker, J., Covaci, A., Creusot, N., David, A., Debrauwer, L., Dervilly, G., Duca, R. C., Fessard, V., Grimalt, J. O., Guerin, T., ... Price, E. J. (2024). Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment. Environment International, 186, 1-16. Article 108585. https://doi.org/10.1016/j.envint.2024.108585

@article{fb03fecda00747b1a343010fb0bfff63,

title = "Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment",

abstract = "The chemical burden on the environment and human population is increasing. Consequently, regulatory risk assessment must keep pace to manage, reduce, and prevent adverse impacts on human and environmental health associated with hazardous chemicals. Surveillance of chemicals of known, emerging, or potential future concern, entering the environment-food-human continuum is needed to document the reality of risks posed by chemicals on ecosystem and human health from a one health perspective, feed into early warning systems and support public policies for exposure mitigation provisions and safe and sustainable by design strategies. The use of less-conventional sampling strategies and integration of full-scan, high-resolution mass spectrometry and effect-directed analysis in environmental and human monitoring programmes have the potential to enhance the screening and identification of a wider range of chemicals of known, emerging or potential future concern. Here, we outline the key needs and recommendations identified within the European Partnership for Assessment of Risks from Chemicals (PARC) project for leveraging these innovative methodologies to support the development of next-generation chemical risk assessment.",

keywords = "Chemical exposure, Chemical risk assessment, Effect-based methods, Effect-directed analysis, High-resolution mass spectrometry, Sampling strategies",

author = "{\v Z}iga Tkalec and Antignac, {Jean Philippe} and Nicole Bandow and B{\'e}en, {Frederic M.} and Lidia Belova and Jos Bessems and {Le Bizec}, Bruno and Werner Brack and German Cano-Sancho and Jade Chaker and Adrian Covaci and Nicolas Creusot and Arthur David and Laurent Debrauwer and Gaud Dervilly and Duca, {Radu Corneliu} and Val{\'e}rie Fessard and Grimalt, {Joan O.} and Thierry Guerin and Baninia Habchi and Helge Hecht and Juliane Hollender and Jamin, {Emilien L.} and Jana Kl{\'a}nov{\'a} and Tina Kosjek and Martin Krauss and Marja Lamoree and Gwenaelle Lavison-Bompard and Jeroen Meijer and Ruth Moeller and Hans Mol and Sophie Mompelat and {Van Nieuwenhuyse}, An and Herbert Oberacher and Julien Parinet and {Van Poucke}, Christof and Robert Ro{\v s}kar and Anne Togola and Jurij Trontelj and Price, {Elliott J.}",

note = "Publisher Copyright: {\textcopyright} 2024",

year = "2024",

month = apr,

doi = "10.1016/j.envint.2024.108585",

language = "English",

volume = "186",

pages = "1--16",

journal = "Environment International",

issn = "0160-4120",

publisher = "Elsevier Ltd",

}

Tkalec, Ž, Antignac, JP, Bandow, N, Béen, FM, Belova, L, Bessems, J, Le Bizec, B, Brack, W, Cano-Sancho, G, Chaker, J, Covaci, A, Creusot, N, David, A, Debrauwer, L, Dervilly, G, Duca, RC, Fessard, V, Grimalt, JO, Guerin, T, Habchi, B, Hecht, H, Hollender, J, Jamin, EL, Klánová, J, Kosjek, T, Krauss, M, Lamoree, M, Lavison-Bompard, G, Meijer, J, Moeller, R, Mol, H, Mompelat, S, Van Nieuwenhuyse, A, Oberacher, H, Parinet, J, Van Poucke, C, Roškar, R, Togola, A, Trontelj, J & Price, EJ 2024, 'Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment', Environment International, vol. 186, 108585, pp. 1-16. https://doi.org/10.1016/j.envint.2024.108585

TY - JOUR

T1 - Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment

AU - Tkalec, Žiga

AU - Antignac, Jean Philippe

AU - Bandow, Nicole

AU - Béen, Frederic M.

AU - Belova, Lidia

AU - Bessems, Jos

AU - Le Bizec, Bruno

AU - Brack, Werner

AU - Cano-Sancho, German

AU - Chaker, Jade

AU - Covaci, Adrian

AU - Creusot, Nicolas

AU - David, Arthur

AU - Debrauwer, Laurent

AU - Dervilly, Gaud

AU - Duca, Radu Corneliu

AU - Fessard, Valérie

AU - Grimalt, Joan O.

AU - Guerin, Thierry

AU - Habchi, Baninia

AU - Hecht, Helge

AU - Hollender, Juliane

AU - Jamin, Emilien L.

AU - Klánová, Jana

AU - Kosjek, Tina

AU - Krauss, Martin

AU - Lamoree, Marja

AU - Lavison-Bompard, Gwenaelle

AU - Meijer, Jeroen

AU - Moeller, Ruth

AU - Mol, Hans

AU - Mompelat, Sophie

AU - Van Nieuwenhuyse, An

AU - Oberacher, Herbert

AU - Parinet, Julien

AU - Van Poucke, Christof

AU - Roškar, Robert

AU - Togola, Anne

AU - Trontelj, Jurij

AU - Price, Elliott J.

PY - 2024/4

Y1 - 2024/4

N2 - The chemical burden on the environment and human population is increasing. Consequently, regulatory risk assessment must keep pace to manage, reduce, and prevent adverse impacts on human and environmental health associated with hazardous chemicals. Surveillance of chemicals of known, emerging, or potential future concern, entering the environment-food-human continuum is needed to document the reality of risks posed by chemicals on ecosystem and human health from a one health perspective, feed into early warning systems and support public policies for exposure mitigation provisions and safe and sustainable by design strategies. The use of less-conventional sampling strategies and integration of full-scan, high-resolution mass spectrometry and effect-directed analysis in environmental and human monitoring programmes have the potential to enhance the screening and identification of a wider range of chemicals of known, emerging or potential future concern. Here, we outline the key needs and recommendations identified within the European Partnership for Assessment of Risks from Chemicals (PARC) project for leveraging these innovative methodologies to support the development of next-generation chemical risk assessment.

AB - The chemical burden on the environment and human population is increasing. Consequently, regulatory risk assessment must keep pace to manage, reduce, and prevent adverse impacts on human and environmental health associated with hazardous chemicals. Surveillance of chemicals of known, emerging, or potential future concern, entering the environment-food-human continuum is needed to document the reality of risks posed by chemicals on ecosystem and human health from a one health perspective, feed into early warning systems and support public policies for exposure mitigation provisions and safe and sustainable by design strategies. The use of less-conventional sampling strategies and integration of full-scan, high-resolution mass spectrometry and effect-directed analysis in environmental and human monitoring programmes have the potential to enhance the screening and identification of a wider range of chemicals of known, emerging or potential future concern. Here, we outline the key needs and recommendations identified within the European Partnership for Assessment of Risks from Chemicals (PARC) project for leveraging these innovative methodologies to support the development of next-generation chemical risk assessment.

KW - Chemical exposure

KW - Chemical risk assessment

KW - Effect-based methods

KW - Effect-directed analysis

KW - High-resolution mass spectrometry

KW - Sampling strategies

UR - http://www.scopus.com/inward/record.url?scp=85188785915&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85188785915&partnerID=8YFLogxK

U2 - 10.1016/j.envint.2024.108585

DO - 10.1016/j.envint.2024.108585

M3 - Article

C2 - 38521044

AN - SCOPUS:85188785915

SN - 0160-4120

VL - 186

SP - 1

EP - 16

JO - Environment International

JF - Environment International

M1 - 108585

ER -

Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment

Abstract

Bibliographical note

Funding

Keywords

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Cite this