Insulin Modulates Cocaine-Sensitive Monoamine Transporter Function and Impulsive Behavior

A.N.M. Schoffelmeer; B. Drukarch; T.J. de Vries; F. Hogenboom; D. Schetters; T. Pattij

doi:10.1523/JNEUROSCI.3779-10.2011

Insulin Modulates Cocaine-Sensitive Monoamine Transporter Function and Impulsive Behavior

A.N.M. Schoffelmeer, B. Drukarch, T.J. de Vries, F. Hogenboom, D. Schetters, T. Pattij

Molecular and Cellular Neurobiology

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Abstract

Because insulin acutely enhances the function of dopamine transporters, the tyrosine kinase receptors activated by this hormone may modulate transporter-dependent neurochemical and behavioral effects of psychoactive drugs. In this respect, we examined the effects of insulin on exocytotic monoamine release and the efficacy of the monoamine transporter blocker cocaine in rat nucleus accumbens. Whereas insulin reduced electrically evoked exocytotic [

Original language	English
Pages (from-to)	1284-1291
Journal	The Journal of Neuroscience
Volume	31
Issue number	4
DOIs	https://doi.org/10.1523/JNEUROSCI.3779-10.2011
Publication status	Published - 2011

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10.1523/JNEUROSCI.3779-10.2011

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title = "Insulin Modulates Cocaine-Sensitive Monoamine Transporter Function and Impulsive Behavior",

abstract = "Because insulin acutely enhances the function of dopamine transporters, the tyrosine kinase receptors activated by this hormone may modulate transporter-dependent neurochemical and behavioral effects of psychoactive drugs. In this respect, we examined the effects of insulin on exocytotic monoamine release and the efficacy of the monoamine transporter blocker cocaine in rat nucleus accumbens. Whereas insulin reduced electrically evoked exocytotic [",

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AU - Schoffelmeer, A.N.M.

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AU - de Vries, T.J.

AU - Hogenboom, F.

AU - Schetters, D.

AU - Pattij, T.

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AB - Because insulin acutely enhances the function of dopamine transporters, the tyrosine kinase receptors activated by this hormone may modulate transporter-dependent neurochemical and behavioral effects of psychoactive drugs. In this respect, we examined the effects of insulin on exocytotic monoamine release and the efficacy of the monoamine transporter blocker cocaine in rat nucleus accumbens. Whereas insulin reduced electrically evoked exocytotic [

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DO - 10.1523/JNEUROSCI.3779-10.2011

M3 - Article

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EP - 1291

JO - The Journal of Neuroscience

JF - The Journal of Neuroscience

IS - 4

ER -

Insulin Modulates Cocaine-Sensitive Monoamine Transporter Function and Impulsive Behavior

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