Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs

L. Roos, J. van Dongen, C.G. Bell, A. Burri, P. Deloukas, D.I. Boomsma, T.D. Spector, J.T. Bell

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

BACKGROUND: A key focus in cancer research is the discovery of biomarkers that accurately diagnose early lesions in non-invasive tissues. Several studies have identified malignancy-associated DNA methylation changes in blood, yet no general cancer biomarker has been identified to date. Here, we explore the potential of blood DNA methylation as a biomarker of pan-cancer (cancer of multiple different origins) in 41 female cancer discordant monozygotic (MZ) twin-pairs sampled before or after diagnosis using the Illumina HumanMethylation450 BeadChip.
Original languageEnglish
Pages (from-to)1-16
JournalClinical epigenetics
Volume8
Issue number7
DOIs
Publication statusPublished - 2016

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