Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs

L. Roos; J. van Dongen; C.G. Bell; A. Burri; P. Deloukas; D.I. Boomsma; T.D. Spector; J.T. Bell

doi:10.1186/s13148-016-0172-y

Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs

L. Roos
, J. van Dongen
, C.G. Bell
, A. Burri
, P. Deloukas
, D.I. Boomsma
, T.D. Spector
, J.T. Bell

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

BACKGROUND: A key focus in cancer research is the discovery of biomarkers that accurately diagnose early lesions in non-invasive tissues. Several studies have identified malignancy-associated DNA methylation changes in blood, yet no general cancer biomarker has been identified to date. Here, we explore the potential of blood DNA methylation as a biomarker of pan-cancer (cancer of multiple different origins) in 41 female cancer discordant monozygotic (MZ) twin-pairs sampled before or after diagnosis using the Illumina HumanMethylation450 BeadChip.

Original language	English
Pages (from-to)	1-16
Journal	Clinical epigenetics
Volume	8
Issue number	7
DOIs	https://doi.org/10.1186/s13148-016-0172-y
Publication status	Published - 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cohort Studies

Netherlands Twin Register (NTR)

Access to Document

10.1186/s13148-016-0172-y

Persistent URL (handle)

Persistent link

Additional file 4: Table S1. of Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs
Roos, L. (Contributor), Dongen, J. V. (Contributor), Bell, C. (Contributor), Burri, A. (Contributor), Deloukas, P. (Contributor), Boomsma, D. (Contributor), Spector, T. (Contributor) & Bell, J. (Contributor), Unknown, 20 Jan 2016
DOI: 10.6084/m9.figshare.c.3644438_d4.v1, https://springernature.figshare.com/articles/dataset/Additional_file_4_Table_S1_of_Integrative_DNA_methylome_analysis_of_pan-cancer_biomarkers_in_cancer_discordant_monozygotic_twin-pairs/4468901/1
Dataset / Software: Dataset
Additional file 4: Table S1. of Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs
Roos, L. (Creator), van Dongen, J. (Contributor), Bell, C. G. (Creator), Burri, A. (Creator), Deloukas, P. (Creator), Boomsma, D. I. (Contributor), Spector, T. D. (Creator) & Bell, J. T. (Creator), Figshare, 2016
DOI: 10.6084/m9.figshare.c.3644438_d4, https://figshare.com/articles/Additional_file_4_Table_S1_of_Integrative_DNA_methylome_analysis_of_pan-cancer_biomarkers_in_cancer_discordant_monozygotic_twin-pairs/4468901
Dataset / Software: Dataset

Cite this

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title = "Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs",

abstract = "BACKGROUND: A key focus in cancer research is the discovery of biomarkers that accurately diagnose early lesions in non-invasive tissues. Several studies have identified malignancy-associated DNA methylation changes in blood, yet no general cancer biomarker has been identified to date. Here, we explore the potential of blood DNA methylation as a biomarker of pan-cancer (cancer of multiple different origins) in 41 female cancer discordant monozygotic (MZ) twin-pairs sampled before or after diagnosis using the Illumina HumanMethylation450 BeadChip.",

author = "L. Roos and \{van Dongen\}, J. and C.G. Bell and A. Burri and P. Deloukas and D.I. Boomsma and T.D. Spector and J.T. Bell",

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AU - Roos, L.

AU - van Dongen, J.

AU - Bell, C.G.

AU - Burri, A.

AU - Deloukas, P.

AU - Boomsma, D.I.

AU - Spector, T.D.

AU - Bell, J.T.

PY - 2016

Y1 - 2016

N2 - BACKGROUND: A key focus in cancer research is the discovery of biomarkers that accurately diagnose early lesions in non-invasive tissues. Several studies have identified malignancy-associated DNA methylation changes in blood, yet no general cancer biomarker has been identified to date. Here, we explore the potential of blood DNA methylation as a biomarker of pan-cancer (cancer of multiple different origins) in 41 female cancer discordant monozygotic (MZ) twin-pairs sampled before or after diagnosis using the Illumina HumanMethylation450 BeadChip.

AB - BACKGROUND: A key focus in cancer research is the discovery of biomarkers that accurately diagnose early lesions in non-invasive tissues. Several studies have identified malignancy-associated DNA methylation changes in blood, yet no general cancer biomarker has been identified to date. Here, we explore the potential of blood DNA methylation as a biomarker of pan-cancer (cancer of multiple different origins) in 41 female cancer discordant monozygotic (MZ) twin-pairs sampled before or after diagnosis using the Illumina HumanMethylation450 BeadChip.

U2 - 10.1186/s13148-016-0172-y

DO - 10.1186/s13148-016-0172-y

M3 - Article

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JO - Clinical epigenetics

JF - Clinical epigenetics

IS - 7

ER -

Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs

Abstract

UN SDGs

Cohort Studies

Access to Document

Persistent URL (handle)

Fingerprint

Datasets

Additional file 4: Table S1. of Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs

Additional file 4: Table S1. of Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs

Cite this