TY - JOUR
T1 - Interaction of pathogenic mycobacteria with the host immune system
AU - Houben, E.N.G.
AU - Nguyen, L.
AU - Pieters, J.
PY - 2006
Y1 - 2006
N2 - Pathogenic mycobacteria, in particular Mycobacterium tuberculosis, the causative agent of tuberculosis, have the remarkable capacity to circumvent destruction within one of the most hostile cell types of a vertebrate host: the macrophage. The ability of pathogenic mycobacteria to survive inside macrophages has been known for more than 30 years; yet, only recently have advances in molecular genetics, biochemistry, immunology, as well as global analysis of gene expression, started to unravel the strategies utilized by these pathogens for intracellular persistence. In addition, the definition of key molecules that are important for intracellular survival opens the possibility to develop new drugs to combat mycobacterial diseases. © 2005 Elsevier Ltd. All rights reserved.
AB - Pathogenic mycobacteria, in particular Mycobacterium tuberculosis, the causative agent of tuberculosis, have the remarkable capacity to circumvent destruction within one of the most hostile cell types of a vertebrate host: the macrophage. The ability of pathogenic mycobacteria to survive inside macrophages has been known for more than 30 years; yet, only recently have advances in molecular genetics, biochemistry, immunology, as well as global analysis of gene expression, started to unravel the strategies utilized by these pathogens for intracellular persistence. In addition, the definition of key molecules that are important for intracellular survival opens the possibility to develop new drugs to combat mycobacterial diseases. © 2005 Elsevier Ltd. All rights reserved.
U2 - 10.1016/j.mib.2005.12.014
DO - 10.1016/j.mib.2005.12.014
M3 - Article
SN - 1369-5274
VL - 9
SP - 76
EP - 85
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
ER -