TY - JOUR
T1 - Interaction proteomics reveals brain region-specific AMPA receptor complexes
AU - Chen, N.
AU - Pandya, N.J.
AU - Koopmans, F.T.W.
AU - Castelo-Szekelv, V.
AU - van der Schors, R.C.
AU - Smit, A.B.
AU - Li, K.W.
PY - 2014
Y1 - 2014
N2 - Fast excitatory synaptic transmission in the brain is mediated by glutamate acting on postsynaptic AMPA receptors. Recent studies have revealed a substantial number of AMPA receptor auxiliary proteins, which potentially contribute to the regulation of AMPA receptor trafficking, subcellular receptor localization, and receptor gating properties. Here we examined the AMPA receptor interactomes from cortex, hippocampus, and cerebellum by comprehensive interaction proteomics. The study reveals that AMPA receptor auxiliary proteins are engaged in distinct brain region-specific AMPA receptors subcomplexes, which might underlie brain region-specific differential regulation of AMPA receptor properties. Depending on the brain region, an interacting protein can be involved in an AMPA and a non-AMPA receptor complex.
AB - Fast excitatory synaptic transmission in the brain is mediated by glutamate acting on postsynaptic AMPA receptors. Recent studies have revealed a substantial number of AMPA receptor auxiliary proteins, which potentially contribute to the regulation of AMPA receptor trafficking, subcellular receptor localization, and receptor gating properties. Here we examined the AMPA receptor interactomes from cortex, hippocampus, and cerebellum by comprehensive interaction proteomics. The study reveals that AMPA receptor auxiliary proteins are engaged in distinct brain region-specific AMPA receptors subcomplexes, which might underlie brain region-specific differential regulation of AMPA receptor properties. Depending on the brain region, an interacting protein can be involved in an AMPA and a non-AMPA receptor complex.
UR - https://www.scopus.com/pages/publications/84915791429
UR - https://www.scopus.com/inward/citedby.url?scp=84915791429&partnerID=8YFLogxK
U2 - 10.1021/pr500697b
DO - 10.1021/pr500697b
M3 - Article
SN - 1535-3893
VL - 13
SP - 5695
EP - 5706
JO - Journal of Proteome Research
JF - Journal of Proteome Research
IS - 12
ER -