TY - JOUR
T1 - Intermittent hypobaric hypoxia exposure does not cause sustained alterations in autonomic control of blood pressure in young athletes.
AU - Fu, Q.
AU - Townsend, N.E.
AU - Shiller, S.M.
AU - Martini, E.R.
AU - Okazaki, K.
AU - Shibata, S.
AU - Truijens, M.J.
AU - Rodriquez, F.A.
AU - Gore, C.J.
AU - Stray-Gundersen, J.
AU - Levine, B.D.
PY - 2007
Y1 - 2007
N2 - Intermittent hypoxia (IH), which refers to the discontinuous use of hypoxia to reproduce some key features of altitude acclimatization, is commonly used in athletes to improve their performance. However, variations of IH are also used as a model for sleep apnea, causing sustained sympathoexcitation and hypertension in animals and, thus, raising concerns over the safety of this model. We tested the hypothesis that chronic IH at rest alters autonomic control of arterial pressure in healthy trained individuals. Twenty-two young athletes (11 men and 11 women) were randomly assigned to hypobaric hypoxia (simulated altitude of 4,000-5,500 m) or normoxia (500 m) in a double-blind and placebo-controlled design. Both groups rested in a hypobaric chamber for 3 h/day, 5 days/wk for 4 wk. In the sitting position, resting hemodynamics, including heart rate (HR), blood pressure (BP), cardiac output (Q̇
AB - Intermittent hypoxia (IH), which refers to the discontinuous use of hypoxia to reproduce some key features of altitude acclimatization, is commonly used in athletes to improve their performance. However, variations of IH are also used as a model for sleep apnea, causing sustained sympathoexcitation and hypertension in animals and, thus, raising concerns over the safety of this model. We tested the hypothesis that chronic IH at rest alters autonomic control of arterial pressure in healthy trained individuals. Twenty-two young athletes (11 men and 11 women) were randomly assigned to hypobaric hypoxia (simulated altitude of 4,000-5,500 m) or normoxia (500 m) in a double-blind and placebo-controlled design. Both groups rested in a hypobaric chamber for 3 h/day, 5 days/wk for 4 wk. In the sitting position, resting hemodynamics, including heart rate (HR), blood pressure (BP), cardiac output (Q̇
U2 - 10.1152/ajpregu.00622.2006
DO - 10.1152/ajpregu.00622.2006
M3 - Article
SN - 0363-6119
VL - 292
SP - R1977-1984
JO - American Journal of Physiology. Regulatory Integrative and Comparative Physiology
JF - American Journal of Physiology. Regulatory Integrative and Comparative Physiology
ER -
