International warfarin genotype-guided dosing algorithms in the Turkish population and their preventive effects on major and life-threatening hemorrhagic events

Sefayet Karaca; Nujen Colak Bozkurt; Tomris Cesuroglu; Mehmet Karaca; Mehmet Bozkurt; Erdal Eskioglu; Renato Polimanti

doi:10.2217/pgs.15.58

International warfarin genotype-guided dosing algorithms in the Turkish population and their preventive effects on major and life-threatening hemorrhagic events

Sefayet Karaca, Nujen Colak Bozkurt, Tomris Cesuroglu, Mehmet Karaca, Mehmet Bozkurt, Erdal Eskioglu, Renato Polimanti

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

AIM: To determine the accuracy of international warfarin pharmacogenetic algorithms developed on large multiethnic cohorts (comprising more than 1000 subjects) to predict therapeutic warfarin doses in Turkish patients.

MATERIALS & METHODS: We investigated two Turkish warfarin-treated cohorts: patients with no history of hemorrhagic or thromboembolic event and patients with major and life-threatening hemorrhagic events.

RESULTS: International pharmacogenetic algorithms showed good performances in predicting the therapeutic dose of patients with no history of bleedings, but they did not significantly detect the incorrect warfarin dose of patients with major and life-threatening hemorrhagic events.

CONCLUSION: Although genetic information can predict the therapeutic warfarin dose, the accuracy of the international pharmacogenetic algorithms is not sufficient to be used for warfarin screening in Turkish patients.

Original language	English
Pages (from-to)	1109-18
Number of pages	10
Journal	Pharmacogenomics
Volume	16
Issue number	10
DOIs	https://doi.org/10.2217/pgs.15.58
Publication status	Published - 2015

Keywords

Aged
Algorithms
Anticoagulants/administration & dosage
Drug Dosage Calculations
Female
Genotype
Hemorrhagic Disorders/genetics
Humans
International Normalized Ratio/methods
Male
Middle Aged
Pharmacogenetics/methods
Thromboembolism/drug therapy
Turkey
Warfarin/administration & dosage

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "International warfarin genotype-guided dosing algorithms in the Turkish population and their preventive effects on major and life-threatening hemorrhagic events",

abstract = "AIM: To determine the accuracy of international warfarin pharmacogenetic algorithms developed on large multiethnic cohorts (comprising more than 1000 subjects) to predict therapeutic warfarin doses in Turkish patients.MATERIALS & METHODS: We investigated two Turkish warfarin-treated cohorts: patients with no history of hemorrhagic or thromboembolic event and patients with major and life-threatening hemorrhagic events.RESULTS: International pharmacogenetic algorithms showed good performances in predicting the therapeutic dose of patients with no history of bleedings, but they did not significantly detect the incorrect warfarin dose of patients with major and life-threatening hemorrhagic events.CONCLUSION: Although genetic information can predict the therapeutic warfarin dose, the accuracy of the international pharmacogenetic algorithms is not sufficient to be used for warfarin screening in Turkish patients.",

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author = "Sefayet Karaca and Bozkurt, {Nujen Colak} and Tomris Cesuroglu and Mehmet Karaca and Mehmet Bozkurt and Erdal Eskioglu and Renato Polimanti",

year = "2015",

doi = "10.2217/pgs.15.58",

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pages = "1109--18",

journal = "Pharmacogenomics",

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TY - JOUR

T1 - International warfarin genotype-guided dosing algorithms in the Turkish population and their preventive effects on major and life-threatening hemorrhagic events

AU - Karaca, Sefayet

AU - Bozkurt, Nujen Colak

AU - Cesuroglu, Tomris

AU - Karaca, Mehmet

AU - Bozkurt, Mehmet

AU - Eskioglu, Erdal

AU - Polimanti, Renato

PY - 2015

Y1 - 2015

N2 - AIM: To determine the accuracy of international warfarin pharmacogenetic algorithms developed on large multiethnic cohorts (comprising more than 1000 subjects) to predict therapeutic warfarin doses in Turkish patients.MATERIALS & METHODS: We investigated two Turkish warfarin-treated cohorts: patients with no history of hemorrhagic or thromboembolic event and patients with major and life-threatening hemorrhagic events.RESULTS: International pharmacogenetic algorithms showed good performances in predicting the therapeutic dose of patients with no history of bleedings, but they did not significantly detect the incorrect warfarin dose of patients with major and life-threatening hemorrhagic events.CONCLUSION: Although genetic information can predict the therapeutic warfarin dose, the accuracy of the international pharmacogenetic algorithms is not sufficient to be used for warfarin screening in Turkish patients.

AB - AIM: To determine the accuracy of international warfarin pharmacogenetic algorithms developed on large multiethnic cohorts (comprising more than 1000 subjects) to predict therapeutic warfarin doses in Turkish patients.MATERIALS & METHODS: We investigated two Turkish warfarin-treated cohorts: patients with no history of hemorrhagic or thromboembolic event and patients with major and life-threatening hemorrhagic events.RESULTS: International pharmacogenetic algorithms showed good performances in predicting the therapeutic dose of patients with no history of bleedings, but they did not significantly detect the incorrect warfarin dose of patients with major and life-threatening hemorrhagic events.CONCLUSION: Although genetic information can predict the therapeutic warfarin dose, the accuracy of the international pharmacogenetic algorithms is not sufficient to be used for warfarin screening in Turkish patients.

KW - Aged

KW - Algorithms

KW - Anticoagulants/administration & dosage

KW - Drug Dosage Calculations

KW - Female

KW - Genotype

KW - Hemorrhagic Disorders/genetics

KW - Humans

KW - International Normalized Ratio/methods

KW - Male

KW - Middle Aged

KW - Pharmacogenetics/methods

KW - Thromboembolism/drug therapy

KW - Turkey

KW - Warfarin/administration & dosage

U2 - 10.2217/pgs.15.58

DO - 10.2217/pgs.15.58

M3 - Article

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SN - 1462-2416

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SP - 1109

EP - 1118

JO - Pharmacogenomics

JF - Pharmacogenomics

IS - 10

ER -

International warfarin genotype-guided dosing algorithms in the Turkish population and their preventive effects on major and life-threatening hemorrhagic events

Abstract

Keywords

UN SDGs

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