Intra-arterial administration of hexobarbital enantiomers to the rat: disposition and estimation of apparent extraction ratio

M Van der Graaff, N P Vermeulen, D D Breimer

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The enantiomers of hexobarbital, designated as S(+)-HB and R(-)-HB, were administered intra-arterially to rats in a dose of 25 mg X kg-1. Blood pharmacokinetics of the parent compound and two metabolites as well as urinary excretion of three major metabolites were studied. Using previously obtained data following oral administration of S(+)-HB and R(-)-HB two different methods for calculation of the hepatic extraction ratio (E) were compared. The metabolite profile in the urine after intra-arterial administration was not basically different from corresponding data on oral administration. The clearance of low-dose, intra-arterially administered S(+)-HB is useful as an indicator of hepatic blood flow in the rat.

Original languageEnglish
Pages (from-to)139-44
Number of pages6
JournalPharmaceutisch weekblad. Scientific edition
Volume8
Issue number2
DOIs
Publication statusPublished - 25 Apr 1986

Keywords

  • Animals
  • Chromatography, Gas
  • Hexobarbital
  • Injections, Intra-Arterial
  • Kinetics
  • Male
  • Rats
  • Rats, Inbred Strains
  • Stereoisomerism
  • Journal Article

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