Intracellular accumulation of aggregated pyroglutamate amyloid beta: convergence of aging and Abeta pathology at the lysosome

L. de Kimpe, E.S. van Haastert, A. Kaminari, R. Zwart, H. Rutjes, J.J.M. Hoozemans, W. Scheper

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Deposition of aggregated amyloid beta (Aβ) is a major hallmark of Alzheimer's disease (AD) - a common age-related neurodegenerative disorder. Typically, Aβ is generated as a peptide of varying lengths. However, a major fraction of Aβ peptides in the brains of AD patients has undergone posttranslational modifications, which often radically change the properties of the peptides. Aβ
Original languageEnglish
Pages (from-to)673-687
JournalAge
Volume35
Issue number3
DOIs
Publication statusPublished - 2013

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