Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium

A.E. Taylor; M.E. Fluharty; J.H. Bjørngaard; M. Elvestad Gabrielsen; F. Skorpen; R.E. Marioni; A. Campbell; J. Engmann; S. Saeed Mirza; A. Loukola; T. Laatikainen; T. Partonen; M. Kaakinen; F. Ducci; A. Cavadino; L.L.N. Husemoen; T. Singh Ahluwalia; R. Kart Jacobsen; T. Skaaby; J. Frost Ebstrup; E. Lykke Mortensen; C.C. Minica; J.M. Vink; G. Willemsen; P. Marques-Vidal; C.E. Dale; A. Amuzu; L.T. Lennon; J. Lahti; A. Palotie; K. Räikkönen; A. Wong; L. Paternoster; A Pui-Yee Wong; L.J. Horwood; M. Murphy; E.C. Johnstone; M.A. Kennedy; Z. Pausova; T. Paus; Y. Ben-Shlomo; E.A. Nohr; D Kuh; M. Kivimaki; J.G. Eriksson; R.W. Morris; J.P. Casas; M. Preisig; D.I. Boomsma; A. Linneberg; C. Power; E. Hyppönen; J. Veijola; M.R. Järvelin; T. Korhonen; H. Tiemeier; M. Kumari; D.J. Porteous; C. Hayward; P.R. Romundstad; G.D. Smith; M.R. Munafo

doi:10.1136/bmjopen-2014-006141

Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium

A.E. Taylor, M.E. Fluharty, J.H. Bjørngaard, M. Elvestad Gabrielsen, F. Skorpen, R.E. Marioni, A. Campbell, J. Engmann, S. Saeed Mirza, A. Loukola, T. Laatikainen, T. Partonen, M. Kaakinen, F. Ducci, A. Cavadino, L.L.N. Husemoen, T. Singh Ahluwalia, R. Kart Jacobsen, T. Skaaby, J. Frost EbstrupE. Lykke Mortensen, C.C. Minica, J.M. Vink, G. Willemsen, P. Marques-Vidal, C.E. Dale, A. Amuzu, L.T. Lennon, J. Lahti, A. Palotie, K. Räikkönen, A. Wong, L. Paternoster, A Pui-Yee Wong, L.J. Horwood, M. Murphy, E.C. Johnstone, M.A. Kennedy, Z. Pausova, T. Paus, Y. Ben-Shlomo, E.A. Nohr, D Kuh, M. Kivimaki, J.G. Eriksson, R.W. Morris, J.P. Casas, M. Preisig, D.I. Boomsma, A. Linneberg, C. Power, E. Hyppönen, J. Veijola, M.R. Järvelin, T. Korhonen, H. Tiemeier, M. Kumari, D.J. Porteous, C. Hayward, P.R. Romundstad, G.D. Smith, M.R. Munafo

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Objectives: To investigate whether associations of smoking with depression and anxiety are likely to be causal, using a Mendelian randomisation approach. Design: Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730) as a proxy for smoking heaviness, and observational meta-analyses of the associations of smoking status and smoking heaviness with depression, anxiety and psychological distress. Participants: Current, former and never smokers of European ancestry aged ≥16 years from 25 studies in the Consortium for Causal Analysis Research in Tobacco and Alcohol (CARTA). Primary outcome measures: Binary definitions of depression, anxiety and psychological distress assessed by clinical interview, symptom scales or self-reported recall of clinician diagnosis. Results: The analytic sample included up to 58 176 never smokers, 37 428 former smokers and 32 028 current smokers (total N=127 632). In observational analyses, current smokers had 1.85 times greater odds of depression (95% CI 1.65 to 2.07), 1.71 times greater odds of anxiety (95% CI 1.54 to 1.90) and 1.69 times greater odds of psychological distress (95% CI 1.56 to 1.83) than never smokers. Former smokers also had greater odds of depression, anxiety and psychological distress than never smokers. There was evidence for positive associations of smoking heaviness with depression, anxiety and psychological distress (ORs per cigarette per day: 1.03 (95% CI 1.02 to 1.04), 1.03 (95% CI 1.02 to 1.04) and 1.02 (95% CI 1.02 to 1.03) respectively). In Mendelian randomisation analyses, there was no strong evidence that the minor allele of rs16969968/rs1051730 was associated with depression (OR=1.00, 95% CI 0.95 to 1.05), anxiety (OR=1.02, 95% CI 0.97 to 1.07) or psychological distress (OR=1.02, 95% CI 0.98 to 1.06) in current smokers. Results were similar for former smokers. Conclusions: Findings from Mendelian randomisation analyses do not support a causal role of smoking heaviness in the development of depression and anxiety.

Original language	English
Article number	e006141
Number of pages	13
Journal	BMJ Open
Volume	4
Issue number	10
DOIs	https://doi.org/10.1136/bmjopen-2014-006141
Publication status	Published - 2014

Cohort Studies

Netherlands Twin Register (NTR)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Taylor, A. E., Fluharty, M. E., Bjørngaard, J. H., Elvestad Gabrielsen, M., Skorpen, F., Marioni, R. E., Campbell, A., Engmann, J., Saeed Mirza, S., Loukola, A., Laatikainen, T., Partonen, T., Kaakinen, M., Ducci, F., Cavadino, A., Husemoen, L. L. N., Singh Ahluwalia, T., Kart Jacobsen, R., Skaaby, T., ... Munafo, M. R. (2014). Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium. BMJ Open, 4(10), [e006141]. https://doi.org/10.1136/bmjopen-2014-006141

Taylor, A.E. ; Fluharty, M.E. ; Bjørngaard, J.H. ; Elvestad Gabrielsen, M. ; Skorpen, F. ; Marioni, R.E. ; Campbell, A. ; Engmann, J. ; Saeed Mirza, S. ; Loukola, A. ; Laatikainen, T. ; Partonen, T. ; Kaakinen, M. ; Ducci, F. ; Cavadino, A. ; Husemoen, L.L.N. ; Singh Ahluwalia, T. ; Kart Jacobsen, R. ; Skaaby, T. ; Frost Ebstrup, J. ; Lykke Mortensen, E. ; Minica, C.C. ; Vink, J.M. ; Willemsen, G. ; Marques-Vidal, P. ; Dale, C.E. ; Amuzu, A. ; Lennon, L.T. ; Lahti, J. ; Palotie, A. ; Räikkönen, K. ; Wong, A. ; Paternoster, L. ; Pui-Yee Wong, A ; Horwood, L.J. ; Murphy, M. ; Johnstone, E.C. ; Kennedy, M.A. ; Pausova, Z. ; Paus, T. ; Ben-Shlomo, Y. ; Nohr, E.A. ; Kuh, D ; Kivimaki, M. ; Eriksson, J.G. ; Morris, R.W. ; Casas, J.P. ; Preisig, M. ; Boomsma, D.I. ; Linneberg, A. ; Power, C. ; Hyppönen, E. ; Veijola, J. ; Järvelin, M.R. ; Korhonen, T. ; Tiemeier, H. ; Kumari, M. ; Porteous, D.J. ; Hayward, C. ; Romundstad, P.R. ; Smith, G.D. ; Munafo, M.R. / Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium. In: BMJ Open. 2014 ; Vol. 4, No. 10.

@article{132679257a644595894e2f25a1e36d0f,

title = "Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium",

abstract = "Objectives: To investigate whether associations of smoking with depression and anxiety are likely to be causal, using a Mendelian randomisation approach. Design: Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730) as a proxy for smoking heaviness, and observational meta-analyses of the associations of smoking status and smoking heaviness with depression, anxiety and psychological distress. Participants: Current, former and never smokers of European ancestry aged ≥16 years from 25 studies in the Consortium for Causal Analysis Research in Tobacco and Alcohol (CARTA). Primary outcome measures: Binary definitions of depression, anxiety and psychological distress assessed by clinical interview, symptom scales or self-reported recall of clinician diagnosis. Results: The analytic sample included up to 58 176 never smokers, 37 428 former smokers and 32 028 current smokers (total N=127 632). In observational analyses, current smokers had 1.85 times greater odds of depression (95% CI 1.65 to 2.07), 1.71 times greater odds of anxiety (95% CI 1.54 to 1.90) and 1.69 times greater odds of psychological distress (95% CI 1.56 to 1.83) than never smokers. Former smokers also had greater odds of depression, anxiety and psychological distress than never smokers. There was evidence for positive associations of smoking heaviness with depression, anxiety and psychological distress (ORs per cigarette per day: 1.03 (95% CI 1.02 to 1.04), 1.03 (95% CI 1.02 to 1.04) and 1.02 (95% CI 1.02 to 1.03) respectively). In Mendelian randomisation analyses, there was no strong evidence that the minor allele of rs16969968/rs1051730 was associated with depression (OR=1.00, 95% CI 0.95 to 1.05), anxiety (OR=1.02, 95% CI 0.97 to 1.07) or psychological distress (OR=1.02, 95% CI 0.98 to 1.06) in current smokers. Results were similar for former smokers. Conclusions: Findings from Mendelian randomisation analyses do not support a causal role of smoking heaviness in the development of depression and anxiety.",

author = "A.E. Taylor and M.E. Fluharty and J.H. Bj{\o}rngaard and {Elvestad Gabrielsen}, M. and F. Skorpen and R.E. Marioni and A. Campbell and J. Engmann and {Saeed Mirza}, S. and A. Loukola and T. Laatikainen and T. Partonen and M. Kaakinen and F. Ducci and A. Cavadino and L.L.N. Husemoen and {Singh Ahluwalia}, T. and {Kart Jacobsen}, R. and T. Skaaby and {Frost Ebstrup}, J. and {Lykke Mortensen}, E. and C.C. Minica and J.M. Vink and G. Willemsen and P. Marques-Vidal and C.E. Dale and A. Amuzu and L.T. Lennon and J. Lahti and A. Palotie and K. R{\"a}ikk{\"o}nen and A. Wong and L. Paternoster and {Pui-Yee Wong}, A and L.J. Horwood and M. Murphy and E.C. Johnstone and M.A. Kennedy and Z. Pausova and T. Paus and Y. Ben-Shlomo and E.A. Nohr and D Kuh and M. Kivimaki and J.G. Eriksson and R.W. Morris and J.P. Casas and M. Preisig and D.I. Boomsma and A. Linneberg and C. Power and E. Hypp{\"o}nen and J. Veijola and M.R. J{\"a}rvelin and T. Korhonen and H. Tiemeier and M. Kumari and D.J. Porteous and C. Hayward and P.R. Romundstad and G.D. Smith and M.R. Munafo",

year = "2014",

doi = "10.1136/bmjopen-2014-006141",

language = "English",

volume = "4",

journal = "BMJ Open",

issn = "2044-6055",

publisher = "BMJ Publishing Group",

number = "10",

}

Taylor, AE, Fluharty, ME, Bjørngaard, JH, Elvestad Gabrielsen, M, Skorpen, F, Marioni, RE, Campbell, A, Engmann, J, Saeed Mirza, S, Loukola, A, Laatikainen, T, Partonen, T, Kaakinen, M, Ducci, F, Cavadino, A, Husemoen, LLN, Singh Ahluwalia, T, Kart Jacobsen, R, Skaaby, T, Frost Ebstrup, J, Lykke Mortensen, E, Minica, CC, Vink, JM, Willemsen, G, Marques-Vidal, P, Dale, CE, Amuzu, A, Lennon, LT, Lahti, J, Palotie, A, Räikkönen, K, Wong, A, Paternoster, L, Pui-Yee Wong, A, Horwood, LJ, Murphy, M, Johnstone, EC, Kennedy, MA, Pausova, Z, Paus, T, Ben-Shlomo, Y, Nohr, EA, Kuh, D, Kivimaki, M, Eriksson, JG, Morris, RW, Casas, JP, Preisig, M, Boomsma, DI, Linneberg, A, Power, C, Hyppönen, E, Veijola, J, Järvelin, MR, Korhonen, T, Tiemeier, H, Kumari, M, Porteous, DJ, Hayward, C, Romundstad, PR, Smith, GD & Munafo, MR 2014, 'Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium', BMJ Open, vol. 4, no. 10, e006141. https://doi.org/10.1136/bmjopen-2014-006141

Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium. / Taylor, A.E.; Fluharty, M.E.; Bjørngaard, J.H.; Elvestad Gabrielsen, M.; Skorpen, F.; Marioni, R.E.; Campbell, A.; Engmann, J.; Saeed Mirza, S.; Loukola, A.; Laatikainen, T.; Partonen, T.; Kaakinen, M.; Ducci, F.; Cavadino, A.; Husemoen, L.L.N.; Singh Ahluwalia, T.; Kart Jacobsen, R.; Skaaby, T.; Frost Ebstrup, J.; Lykke Mortensen, E.; Minica, C.C.; Vink, J.M.; Willemsen, G.; Marques-Vidal, P.; Dale, C.E.; Amuzu, A.; Lennon, L.T.; Lahti, J.; Palotie, A.; Räikkönen, K.; Wong, A.; Paternoster, L.; Pui-Yee Wong, A; Horwood, L.J.; Murphy, M.; Johnstone, E.C.; Kennedy, M.A.; Pausova, Z.; Paus, T.; Ben-Shlomo, Y.; Nohr, E.A.; Kuh, D; Kivimaki, M.; Eriksson, J.G.; Morris, R.W.; Casas, J.P.; Preisig, M.; Boomsma, D.I.; Linneberg, A.; Power, C.; Hyppönen, E.; Veijola, J.; Järvelin, M.R.; Korhonen, T.; Tiemeier, H.; Kumari, M.; Porteous, D.J.; Hayward, C.; Romundstad, P.R.; Smith, G.D.; Munafo, M.R.

In: BMJ Open, Vol. 4, No. 10, e006141, 2014.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium

AU - Taylor, A.E.

AU - Fluharty, M.E.

AU - Bjørngaard, J.H.

AU - Elvestad Gabrielsen, M.

AU - Skorpen, F.

AU - Marioni, R.E.

AU - Campbell, A.

AU - Engmann, J.

AU - Saeed Mirza, S.

AU - Loukola, A.

AU - Laatikainen, T.

AU - Partonen, T.

AU - Kaakinen, M.

AU - Ducci, F.

AU - Cavadino, A.

AU - Husemoen, L.L.N.

AU - Singh Ahluwalia, T.

AU - Kart Jacobsen, R.

AU - Skaaby, T.

AU - Frost Ebstrup, J.

AU - Lykke Mortensen, E.

AU - Minica, C.C.

AU - Vink, J.M.

AU - Willemsen, G.

AU - Marques-Vidal, P.

AU - Dale, C.E.

AU - Amuzu, A.

AU - Lennon, L.T.

AU - Lahti, J.

AU - Palotie, A.

AU - Räikkönen, K.

AU - Wong, A.

AU - Paternoster, L.

AU - Pui-Yee Wong, A

AU - Horwood, L.J.

AU - Murphy, M.

AU - Johnstone, E.C.

AU - Kennedy, M.A.

AU - Pausova, Z.

AU - Paus, T.

AU - Ben-Shlomo, Y.

AU - Nohr, E.A.

AU - Kuh, D

AU - Kivimaki, M.

AU - Eriksson, J.G.

AU - Morris, R.W.

AU - Casas, J.P.

AU - Preisig, M.

AU - Boomsma, D.I.

AU - Linneberg, A.

AU - Power, C.

AU - Hyppönen, E.

AU - Veijola, J.

AU - Järvelin, M.R.

AU - Korhonen, T.

AU - Tiemeier, H.

AU - Kumari, M.

AU - Porteous, D.J.

AU - Hayward, C.

AU - Romundstad, P.R.

AU - Smith, G.D.

AU - Munafo, M.R.

PY - 2014

Y1 - 2014

N2 - Objectives: To investigate whether associations of smoking with depression and anxiety are likely to be causal, using a Mendelian randomisation approach. Design: Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730) as a proxy for smoking heaviness, and observational meta-analyses of the associations of smoking status and smoking heaviness with depression, anxiety and psychological distress. Participants: Current, former and never smokers of European ancestry aged ≥16 years from 25 studies in the Consortium for Causal Analysis Research in Tobacco and Alcohol (CARTA). Primary outcome measures: Binary definitions of depression, anxiety and psychological distress assessed by clinical interview, symptom scales or self-reported recall of clinician diagnosis. Results: The analytic sample included up to 58 176 never smokers, 37 428 former smokers and 32 028 current smokers (total N=127 632). In observational analyses, current smokers had 1.85 times greater odds of depression (95% CI 1.65 to 2.07), 1.71 times greater odds of anxiety (95% CI 1.54 to 1.90) and 1.69 times greater odds of psychological distress (95% CI 1.56 to 1.83) than never smokers. Former smokers also had greater odds of depression, anxiety and psychological distress than never smokers. There was evidence for positive associations of smoking heaviness with depression, anxiety and psychological distress (ORs per cigarette per day: 1.03 (95% CI 1.02 to 1.04), 1.03 (95% CI 1.02 to 1.04) and 1.02 (95% CI 1.02 to 1.03) respectively). In Mendelian randomisation analyses, there was no strong evidence that the minor allele of rs16969968/rs1051730 was associated with depression (OR=1.00, 95% CI 0.95 to 1.05), anxiety (OR=1.02, 95% CI 0.97 to 1.07) or psychological distress (OR=1.02, 95% CI 0.98 to 1.06) in current smokers. Results were similar for former smokers. Conclusions: Findings from Mendelian randomisation analyses do not support a causal role of smoking heaviness in the development of depression and anxiety.

AB - Objectives: To investigate whether associations of smoking with depression and anxiety are likely to be causal, using a Mendelian randomisation approach. Design: Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730) as a proxy for smoking heaviness, and observational meta-analyses of the associations of smoking status and smoking heaviness with depression, anxiety and psychological distress. Participants: Current, former and never smokers of European ancestry aged ≥16 years from 25 studies in the Consortium for Causal Analysis Research in Tobacco and Alcohol (CARTA). Primary outcome measures: Binary definitions of depression, anxiety and psychological distress assessed by clinical interview, symptom scales or self-reported recall of clinician diagnosis. Results: The analytic sample included up to 58 176 never smokers, 37 428 former smokers and 32 028 current smokers (total N=127 632). In observational analyses, current smokers had 1.85 times greater odds of depression (95% CI 1.65 to 2.07), 1.71 times greater odds of anxiety (95% CI 1.54 to 1.90) and 1.69 times greater odds of psychological distress (95% CI 1.56 to 1.83) than never smokers. Former smokers also had greater odds of depression, anxiety and psychological distress than never smokers. There was evidence for positive associations of smoking heaviness with depression, anxiety and psychological distress (ORs per cigarette per day: 1.03 (95% CI 1.02 to 1.04), 1.03 (95% CI 1.02 to 1.04) and 1.02 (95% CI 1.02 to 1.03) respectively). In Mendelian randomisation analyses, there was no strong evidence that the minor allele of rs16969968/rs1051730 was associated with depression (OR=1.00, 95% CI 0.95 to 1.05), anxiety (OR=1.02, 95% CI 0.97 to 1.07) or psychological distress (OR=1.02, 95% CI 0.98 to 1.06) in current smokers. Results were similar for former smokers. Conclusions: Findings from Mendelian randomisation analyses do not support a causal role of smoking heaviness in the development of depression and anxiety.

U2 - 10.1136/bmjopen-2014-006141

DO - 10.1136/bmjopen-2014-006141

M3 - Article

VL - 4

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 10

M1 - e006141

ER -

Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium

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