Investigation of Methodological Factors Potentially Underlying the Apparently Paradoxical Findings on Body Mass Index and All-Cause Mortality

G. Joshy, R.J. Korda, A. Bauman, H.P. van der Ploeg, T. Chey, E. Banks

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    Introduction: Findings regarding the association between overweight and all-cause mortality range from significantly lower to higher risk, compared with body-mass-index (BMI) within the "normal" range. Methods: We examined empirically potential methodological explanations for these apparently conflicting results using questionnaire and linked mortality data from 246,314 individuals aged ≥45 years in the Australian 45 and Up Study (11,127 deaths; median follow-up 3.9 years). Hazard ratios (HR) for all-cause mortality associated with BMI were modelled according to different methods of accounting for illness at baseline, finer versus broader gradations of BMI and choice of reference group, adjusting for potential confounders. Results: In analyses using the broad World Health Organization (WHO) categories, the all-cause mortality HR was significantly lower in the overweight category (25.0-29.99 kg/m
    Original languageEnglish
    Article numbere88641
    JournalPLoS ONE
    Volume9
    Issue number2
    DOIs
    Publication statusPublished - 2014

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