Investigation of on-line reversed-phase liquid chromatography-gas chromatography-mass spectrometry as a tool for the identification of impurities in drug substances.

E.C. Goosens; K.H. Stegman; D. de Jong; G.J. de Jong; U.A.T. Brinkman

doi:10.1039/an9962100061

Investigation of on-line reversed-phase liquid chromatography-gas chromatography-mass spectrometry as a tool for the identification of impurities in drug substances.

E.C. Goosens, K.H. Stegman, D. de Jong, G.J. de Jong, U.A.T. Brinkman

BioAnalytical Chemistry

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The potential of on-line reversed-phase (RP) LC-GC-MS for the identification of impurities in pharmaceutical products has been investigated. The technical aspects of the system were studied using the potential drug eltoprazine as test compound. After LC separation on a 2 mm id RPLC column, using 5 mmol l

Original language	English
Pages (from-to)	61-66
Journal	Analyst
Volume	121
DOIs	https://doi.org/10.1039/an9962100061
Publication status	Published - 1996

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1039/an9962100061

Persistent URL (handle)

Persistent link

Cite this

@article{568bffd6bc40483994ed2747c09075e0,

title = "Investigation of on-line reversed-phase liquid chromatography-gas chromatography-mass spectrometry as a tool for the identification of impurities in drug substances.",

abstract = "The potential of on-line reversed-phase (RP) LC-GC-MS for the identification of impurities in pharmaceutical products has been investigated. The technical aspects of the system were studied using the potential drug eltoprazine as test compound. After LC separation on a 2 mm id RPLC column, using 5 mmol l",

author = "E.C. Goosens and K.H. Stegman and {de Jong}, D. and {de Jong}, G.J. and U.A.T. Brinkman",

year = "1996",

doi = "10.1039/an9962100061",

language = "English",

volume = "121",

pages = "61--66",

journal = "Analyst",

issn = "0003-2654",

publisher = "Royal Society of Chemistry",

}

TY - JOUR

T1 - Investigation of on-line reversed-phase liquid chromatography-gas chromatography-mass spectrometry as a tool for the identification of impurities in drug substances.

AU - Goosens, E.C.

AU - Stegman, K.H.

AU - de Jong, D.

AU - de Jong, G.J.

AU - Brinkman, U.A.T.

PY - 1996

Y1 - 1996

N2 - The potential of on-line reversed-phase (RP) LC-GC-MS for the identification of impurities in pharmaceutical products has been investigated. The technical aspects of the system were studied using the potential drug eltoprazine as test compound. After LC separation on a 2 mm id RPLC column, using 5 mmol l

AB - The potential of on-line reversed-phase (RP) LC-GC-MS for the identification of impurities in pharmaceutical products has been investigated. The technical aspects of the system were studied using the potential drug eltoprazine as test compound. After LC separation on a 2 mm id RPLC column, using 5 mmol l

U2 - 10.1039/an9962100061

DO - 10.1039/an9962100061

M3 - Article

SN - 0003-2654

VL - 121

SP - 61

EP - 66

JO - Analyst

JF - Analyst

ER -

Investigation of on-line reversed-phase liquid chromatography-gas chromatography-mass spectrometry as a tool for the identification of impurities in drug substances.

Abstract

UN SDGs

Access to Document

Persistent URL (handle)

Fingerprint

Cite this