Investigation of on-line reversed-phase liquid chromatography-gas chromatography-mass spectrometry as a tool for the identification of impurities in drug substances.

E.C. Goosens; K.H. Stegman; D. de Jong; G.J. de Jong; U.A.T. Brinkman

doi:10.1039/an9962100061

Investigation of on-line reversed-phase liquid chromatography-gas chromatography-mass spectrometry as a tool for the identification of impurities in drug substances.

E.C. Goosens
, K.H. Stegman
, D. de Jong
, G.J. de Jong
, U.A.T. Brinkman

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The potential of on-line reversed-phase (RP) LC-GC-MS for the identification of impurities in pharmaceutical products has been investigated. The technical aspects of the system were studied using the potential drug eltoprazine as test compound. After LC separation on a 2 mm id RPLC column, using 5 mmol l

Original language	English
Pages (from-to)	61-66
Journal	Analyst
Volume	121
DOIs	https://doi.org/10.1039/an9962100061
Publication status	Published - 1996

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10.1039/an9962100061

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title = "Investigation of on-line reversed-phase liquid chromatography-gas chromatography-mass spectrometry as a tool for the identification of impurities in drug substances.",

abstract = "The potential of on-line reversed-phase (RP) LC-GC-MS for the identification of impurities in pharmaceutical products has been investigated. The technical aspects of the system were studied using the potential drug eltoprazine as test compound. After LC separation on a 2 mm id RPLC column, using 5 mmol l",

author = "E.C. Goosens and K.H. Stegman and \{de Jong\}, D. and \{de Jong\}, G.J. and U.A.T. Brinkman",

year = "1996",

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AU - de Jong, G.J.

AU - Brinkman, U.A.T.

PY - 1996

Y1 - 1996

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AB - The potential of on-line reversed-phase (RP) LC-GC-MS for the identification of impurities in pharmaceutical products has been investigated. The technical aspects of the system were studied using the potential drug eltoprazine as test compound. After LC separation on a 2 mm id RPLC column, using 5 mmol l

U2 - 10.1039/an9962100061

DO - 10.1039/an9962100061

M3 - Article

SN - 0003-2654

VL - 121

SP - 61

EP - 66

JO - Analyst

JF - Analyst

ER -

Investigation of on-line reversed-phase liquid chromatography-gas chromatography-mass spectrometry as a tool for the identification of impurities in drug substances.

Abstract

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