Irradiation of localized squamous cell carcinoma of the nasal vestibule

B.G.L. Vanneste; M. Lopez-Yurda; I.B. Tan; A.J.M. Balm; G.R. Borst; C.R. Rasch

doi:10.1002/hed.24337

Irradiation of localized squamous cell carcinoma of the nasal vestibule

B.G.L. Vanneste, M. Lopez-Yurda, I.B. Tan, A.J.M. Balm, G.R. Borst, C.R. Rasch

Maxillofacial Surgery (AMC)

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background. The purpose of this study was to evaluate the long-term results of primary radiotherapy treatment for squamous cell carcinoma (SCC) of the nasal vestibule.
Methods. Eighty-one patients were treated with external beam radiotherapy (EBRT) and/or interstitial radiotherapy (IRT) for a primary, localized, Wang classified SCC of the nasal vestibule.
Results. Median follow-up was 38 months. T1 tumors were treated with IRT: we observed 1 local failure (at 13 months) among 48 patients (5-year local control rate of 97%). Most T2 tumors (20 of 26) were treated with EBRT. There were 8 local recurrences among 26 patients (5-year local control rate of 68%). For the T3 tumors (n = 7; all treated with EBRT), we observed local recurrence in 2 patients (5-year local control rate of 53%). The late-term side effects were relatively mild.
Conclusion. Local primary radiotherapy (either IRT for T1 or EBRT for T2/3) is an adequate treatment for SCC of the nasal vestibule with little late sequelae.

Original language	English
Pages (from-to)	E1870-E1875
Number of pages	6
Journal	Head and Neck
Volume	38
Issue number	S1
DOIs	https://doi.org/10.1002/hed.24337
Publication status	Published - 2016

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title = "Irradiation of localized squamous cell carcinoma of the nasal vestibule",

abstract = "Background. The purpose of this study was to evaluate the long-term results of primary radiotherapy treatment for squamous cell carcinoma (SCC) of the nasal vestibule.Methods. Eighty-one patients were treated with external beam radiotherapy (EBRT) and/or interstitial radiotherapy (IRT) for a primary, localized, Wang classified SCC of the nasal vestibule.Results. Median follow-up was 38 months. T1 tumors were treated with IRT: we observed 1 local failure (at 13 months) among 48 patients (5-year local control rate of 97%). Most T2 tumors (20 of 26) were treated with EBRT. There were 8 local recurrences among 26 patients (5-year local control rate of 68%). For the T3 tumors (n = 7; all treated with EBRT), we observed local recurrence in 2 patients (5-year local control rate of 53%). The late-term side effects were relatively mild.Conclusion. Local primary radiotherapy (either IRT for T1 or EBRT for T2/3) is an adequate treatment for SCC of the nasal vestibule with little late sequelae.",

author = "B.G.L. Vanneste and M. Lopez-Yurda and I.B. Tan and A.J.M. Balm and G.R. Borst and C.R. Rasch",

year = "2016",

doi = "10.1002/hed.24337",

language = "English",

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pages = "E1870--E1875",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley and Sons Inc.",

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TY - JOUR

T1 - Irradiation of localized squamous cell carcinoma of the nasal vestibule

AU - Vanneste, B.G.L.

AU - Lopez-Yurda, M.

AU - Tan, I.B.

AU - Balm, A.J.M.

AU - Borst, G.R.

AU - Rasch, C.R.

PY - 2016

Y1 - 2016

N2 - Background. The purpose of this study was to evaluate the long-term results of primary radiotherapy treatment for squamous cell carcinoma (SCC) of the nasal vestibule.Methods. Eighty-one patients were treated with external beam radiotherapy (EBRT) and/or interstitial radiotherapy (IRT) for a primary, localized, Wang classified SCC of the nasal vestibule.Results. Median follow-up was 38 months. T1 tumors were treated with IRT: we observed 1 local failure (at 13 months) among 48 patients (5-year local control rate of 97%). Most T2 tumors (20 of 26) were treated with EBRT. There were 8 local recurrences among 26 patients (5-year local control rate of 68%). For the T3 tumors (n = 7; all treated with EBRT), we observed local recurrence in 2 patients (5-year local control rate of 53%). The late-term side effects were relatively mild.Conclusion. Local primary radiotherapy (either IRT for T1 or EBRT for T2/3) is an adequate treatment for SCC of the nasal vestibule with little late sequelae.

AB - Background. The purpose of this study was to evaluate the long-term results of primary radiotherapy treatment for squamous cell carcinoma (SCC) of the nasal vestibule.Methods. Eighty-one patients were treated with external beam radiotherapy (EBRT) and/or interstitial radiotherapy (IRT) for a primary, localized, Wang classified SCC of the nasal vestibule.Results. Median follow-up was 38 months. T1 tumors were treated with IRT: we observed 1 local failure (at 13 months) among 48 patients (5-year local control rate of 97%). Most T2 tumors (20 of 26) were treated with EBRT. There were 8 local recurrences among 26 patients (5-year local control rate of 68%). For the T3 tumors (n = 7; all treated with EBRT), we observed local recurrence in 2 patients (5-year local control rate of 53%). The late-term side effects were relatively mild.Conclusion. Local primary radiotherapy (either IRT for T1 or EBRT for T2/3) is an adequate treatment for SCC of the nasal vestibule with little late sequelae.

U2 - 10.1002/hed.24337

DO - 10.1002/hed.24337

M3 - Article

SN - 1043-3074

VL - 38

SP - E1870-E1875

JO - Head and Neck

JF - Head and Neck

IS - S1

ER -

Irradiation of localized squamous cell carcinoma of the nasal vestibule

Abstract

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