TY - JOUR
T1 - Is depression associated with increased oxidative stress? A systematic review and meta-analysis.
AU - Black, C.N.
AU - Bot, M.
AU - Scheffer, P.G.
AU - Cuijpers, P.
AU - Penninx, B.W.J.H.
PY - 2015
Y1 - 2015
N2 - Background: It has been suggested that depressed persons have increased oxidative stress and decreased anti-oxidant defences. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) and F2-isoprostanes, measures of oxidative DNA and lipid damage respectively, are among the most reliable oxidative stress markers, but studies on their association with depression show conflicting results. This meta-analysis quantifies the association between depression and these markers and explores factors that may explain inconsistencies in the results. Methods: A systematic literature search was conducted in PubMed, EMBASE and PsycINFO. Studies assessing the association of 8-OHdG or F2-isoprostanes with elevated depressive symptoms, major depressive disorder (MDD) or bipolar disorder (BD) were pooled in two random-effect models. Results: The pooled effect size (Hedges' g) for the association of depression with oxidative stress was 0.31 (p=0.01, I
AB - Background: It has been suggested that depressed persons have increased oxidative stress and decreased anti-oxidant defences. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) and F2-isoprostanes, measures of oxidative DNA and lipid damage respectively, are among the most reliable oxidative stress markers, but studies on their association with depression show conflicting results. This meta-analysis quantifies the association between depression and these markers and explores factors that may explain inconsistencies in the results. Methods: A systematic literature search was conducted in PubMed, EMBASE and PsycINFO. Studies assessing the association of 8-OHdG or F2-isoprostanes with elevated depressive symptoms, major depressive disorder (MDD) or bipolar disorder (BD) were pooled in two random-effect models. Results: The pooled effect size (Hedges' g) for the association of depression with oxidative stress was 0.31 (p=0.01, I
U2 - 10.1016/j.psyneuen.2014.09.025
DO - 10.1016/j.psyneuen.2014.09.025
M3 - Article
SN - 0306-4530
VL - 51
SP - 164
EP - 175
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
ER -