Is depression associated with increased oxidative stress? A systematic review and meta-analysis.

C.N. Black; M. Bot; P.G. Scheffer; P. Cuijpers; B.W.J.H. Penninx

doi:10.1016/j.psyneuen.2014.09.025

Is depression associated with increased oxidative stress? A systematic review and meta-analysis.

C.N. Black
, M. Bot
, P.G. Scheffer
, P. Cuijpers
, B.W.J.H. Penninx

Clinical Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background: It has been suggested that depressed persons have increased oxidative stress and decreased anti-oxidant defences. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) and F2-isoprostanes, measures of oxidative DNA and lipid damage respectively, are among the most reliable oxidative stress markers, but studies on their association with depression show conflicting results. This meta-analysis quantifies the association between depression and these markers and explores factors that may explain inconsistencies in the results. Methods: A systematic literature search was conducted in PubMed, EMBASE and PsycINFO. Studies assessing the association of 8-OHdG or F2-isoprostanes with elevated depressive symptoms, major depressive disorder (MDD) or bipolar disorder (BD) were pooled in two random-effect models. Results: The pooled effect size (Hedges' g) for the association of depression with oxidative stress was 0.31 (p=0.01, I

Original language	English
Pages (from-to)	164-175
Journal	Psychoneuroendocrinology
Volume	51
DOIs	https://doi.org/10.1016/j.psyneuen.2014.09.025
Publication status	Published - 2015

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.psyneuen.2014.09.025

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title = "Is depression associated with increased oxidative stress? A systematic review and meta-analysis.",

abstract = "Background: It has been suggested that depressed persons have increased oxidative stress and decreased anti-oxidant defences. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) and F2-isoprostanes, measures of oxidative DNA and lipid damage respectively, are among the most reliable oxidative stress markers, but studies on their association with depression show conflicting results. This meta-analysis quantifies the association between depression and these markers and explores factors that may explain inconsistencies in the results. Methods: A systematic literature search was conducted in PubMed, EMBASE and PsycINFO. Studies assessing the association of 8-OHdG or F2-isoprostanes with elevated depressive symptoms, major depressive disorder (MDD) or bipolar disorder (BD) were pooled in two random-effect models. Results: The pooled effect size (Hedges' g) for the association of depression with oxidative stress was 0.31 (p=0.01, I",

author = "C.N. Black and M. Bot and P.G. Scheffer and P. Cuijpers and B.W.J.H. Penninx",

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doi = "10.1016/j.psyneuen.2014.09.025",

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journal = "Psychoneuroendocrinology",

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T1 - Is depression associated with increased oxidative stress? A systematic review and meta-analysis.

AU - Black, C.N.

AU - Bot, M.

AU - Scheffer, P.G.

AU - Cuijpers, P.

AU - Penninx, B.W.J.H.

PY - 2015

Y1 - 2015

N2 - Background: It has been suggested that depressed persons have increased oxidative stress and decreased anti-oxidant defences. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) and F2-isoprostanes, measures of oxidative DNA and lipid damage respectively, are among the most reliable oxidative stress markers, but studies on their association with depression show conflicting results. This meta-analysis quantifies the association between depression and these markers and explores factors that may explain inconsistencies in the results. Methods: A systematic literature search was conducted in PubMed, EMBASE and PsycINFO. Studies assessing the association of 8-OHdG or F2-isoprostanes with elevated depressive symptoms, major depressive disorder (MDD) or bipolar disorder (BD) were pooled in two random-effect models. Results: The pooled effect size (Hedges' g) for the association of depression with oxidative stress was 0.31 (p=0.01, I

AB - Background: It has been suggested that depressed persons have increased oxidative stress and decreased anti-oxidant defences. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) and F2-isoprostanes, measures of oxidative DNA and lipid damage respectively, are among the most reliable oxidative stress markers, but studies on their association with depression show conflicting results. This meta-analysis quantifies the association between depression and these markers and explores factors that may explain inconsistencies in the results. Methods: A systematic literature search was conducted in PubMed, EMBASE and PsycINFO. Studies assessing the association of 8-OHdG or F2-isoprostanes with elevated depressive symptoms, major depressive disorder (MDD) or bipolar disorder (BD) were pooled in two random-effect models. Results: The pooled effect size (Hedges' g) for the association of depression with oxidative stress was 0.31 (p=0.01, I

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DO - 10.1016/j.psyneuen.2014.09.025

M3 - Article

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VL - 51

SP - 164

EP - 175

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

ER -

Is depression associated with increased oxidative stress? A systematic review and meta-analysis.

Abstract

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