Is distance from equilibrium a good indicator for a reaction's flux control?

David D. van Niekerk; Erik Rust; Frank Bruggeman; Hans V. Westerhoff; Jacky L. Snoep

doi:10.1016/j.biosystems.2023.104988

Is distance from equilibrium a good indicator for a reaction's flux control?

David D. van Niekerk, Erik Rust, Frank Bruggeman, Hans V. Westerhoff, Jacky L. Snoep^*

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

By analysing a large set of models obtained from the JWS Online and Biomodels databases, we tested to what extent the disequilibrium ratio can be used as an estimator for the flux control of a reaction, a discussion point that was already raised by Kacser and Burns, and Heinrich and Rapoport in their seminal MCA manuscripts. Whereas no functional relation was observed, the disequilibrium ratio can be used as an estimator for the maximal flux control of a reaction step. We extended the original analysis of the relationship by incorporating the overall pathway disequilibrium ratio in the expression, which made it possible to make explicit expressions for flux control coefficients.

Original language	English
Article number	104988
Pages (from-to)	1-8
Number of pages	8
Journal	BioSystems
Volume	232
Early online date	2 Aug 2023
DOIs	https://doi.org/10.1016/j.biosystems.2023.104988
Publication status	Published - Oct 2023

Bibliographical note

Funding Information:
This work was part funded by the DST/NRF in South Africa , particularly the SARChI initiative ( NRF-SARCHI-82813 ) and the SRUG2204173612 grants .

Publisher Copyright:
© 2023 The Author(s)

Funding

This work was part funded by the DST/NRF in South Africa , particularly the SARChI initiative ( NRF-SARCHI-82813 ) and the SRUG2204173612 grants .

Funders	Funder number
Department of Science and Technology, Republic of South Africa	SRUG2204173612, NRF-SARCHI-82813
Department of Science and Technology, Republic of South Africa

Keywords

Elasticity coefficients
Metabolic control analysis
Model databases
Non equilibrium thermodynamics
Rate-limiting step

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10.1016/j.biosystems.2023.104988

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Cite this

@article{fdddb5e53c1f4206b6ba9c1c2296725b,

title = "Is distance from equilibrium a good indicator for a reaction's flux control?",

abstract = "By analysing a large set of models obtained from the JWS Online and Biomodels databases, we tested to what extent the disequilibrium ratio can be used as an estimator for the flux control of a reaction, a discussion point that was already raised by Kacser and Burns, and Heinrich and Rapoport in their seminal MCA manuscripts. Whereas no functional relation was observed, the disequilibrium ratio can be used as an estimator for the maximal flux control of a reaction step. We extended the original analysis of the relationship by incorporating the overall pathway disequilibrium ratio in the expression, which made it possible to make explicit expressions for flux control coefficients.",

keywords = "Elasticity coefficients, Metabolic control analysis, Model databases, Non equilibrium thermodynamics, Rate-limiting step",

author = "{van Niekerk}, {David D.} and Erik Rust and Frank Bruggeman and Westerhoff, {Hans V.} and Snoep, {Jacky L.}",

note = "Funding Information: This work was part funded by the DST/NRF in South Africa , particularly the SARChI initiative ( NRF-SARCHI-82813 ) and the SRUG2204173612 grants . Publisher Copyright: {\textcopyright} 2023 The Author(s)",

year = "2023",

month = oct,

doi = "10.1016/j.biosystems.2023.104988",

language = "English",

volume = "232",

pages = "1--8",

journal = "BioSystems",