Is plaque regrowth inhibited by dentifrice?: A systematic review and meta-analysis with trial sequential analysis

C. Valkenburg; F. Van der Weijden; D.E. Slot

doi:10.1111/idh.12364

Is plaque regrowth inhibited by dentifrice? A systematic review and meta-analysis with trial sequential analysis

C. Valkenburg, F. Van der Weijden, D.E. Slot

Periodontology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Objectives: The aim of this systematic review was to establish in studies with human participants the effect of a regular fluoride dentifrice compared to water or saline on dental plaque inhibition. Methods: MEDLINE-PubMed, Cochrane-CENTRAL, EMBASE and other electronic databases were searched, up to April 2018. The inclusion criteria were controlled clinical trials among participants aged ≥18 years with good general health. Papers that evaluated the effect of dentifrice slurry compared with water or saline on plaque regrowth during a 4-day nonbrushing period were included. Data were extracted from the eligible studies, the risk of bias was assessed, and a meta-analysis was performed where feasible. Result: The search retrieved eight eligible publications including 25 comparisons. The estimated potential risk of bias was low for all studies. Based on three different indices, overall plaque regrowth was significantly (P < 0.01) inhibited for 0.25 or more by the use of a dentifrice slurry as compared to water. All subanalysis on specific dentifrice ingredients and the overall descriptive analysis supported these findings. Conclusion: The results of this review demonstrate moderate-quality evidence for a weak inhibitory effect on plaque regrowth in favour of the use of a dentifrice intended for daily use.

Original language	English
Pages (from-to)	27-38
Journal	International Journal of Dental Hygiene
Volume	17
Issue number	1
DOIs	https://doi.org/10.1111/idh.12364
Publication status	Published - 2019

Funding

The authors gratefully acknowledge the support of Joost Bouwman, the head librarian of the ACTA, and Franc van der Vlugt, the head librarian of the KNMT mediacentrum, who helped retrieve full-text papers. The authors are also grateful to Prof. Dr. M. Addy for his responses, time and effort in searching for additional data. In addition, independent statistician Sharon Klaassen is acknowledged for the help in converting the imperial measurements.

Funders	Funder number
Franc van der Vlugt
Joost Bouwman
Alliance for California Traditional Arts

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://hdl.handle.net/11245.1/b4087bbd-11fe-4d98-b52f-c5f6600de8dc

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Cite this

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title = "Is plaque regrowth inhibited by dentifrice?: A systematic review and meta-analysis with trial sequential analysis",

abstract = "Objectives: The aim of this systematic review was to establish in studies with human participants the effect of a regular fluoride dentifrice compared to water or saline on dental plaque inhibition. Methods: MEDLINE-PubMed, Cochrane-CENTRAL, EMBASE and other electronic databases were searched, up to April 2018. The inclusion criteria were controlled clinical trials among participants aged ≥18 years with good general health. Papers that evaluated the effect of dentifrice slurry compared with water or saline on plaque regrowth during a 4-day nonbrushing period were included. Data were extracted from the eligible studies, the risk of bias was assessed, and a meta-analysis was performed where feasible. Result: The search retrieved eight eligible publications including 25 comparisons. The estimated potential risk of bias was low for all studies. Based on three different indices, overall plaque regrowth was significantly (P < 0.01) inhibited for 0.25 or more by the use of a dentifrice slurry as compared to water. All subanalysis on specific dentifrice ingredients and the overall descriptive analysis supported these findings. Conclusion: The results of this review demonstrate moderate-quality evidence for a weak inhibitory effect on plaque regrowth in favour of the use of a dentifrice intended for daily use.",

author = "C. Valkenburg and \{Van der Weijden\}, F. and D.E. Slot",

year = "2019",

doi = "10.1111/idh.12364",

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AU - Van der Weijden, F.

AU - Slot, D.E.

PY - 2019

Y1 - 2019

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AB - Objectives: The aim of this systematic review was to establish in studies with human participants the effect of a regular fluoride dentifrice compared to water or saline on dental plaque inhibition. Methods: MEDLINE-PubMed, Cochrane-CENTRAL, EMBASE and other electronic databases were searched, up to April 2018. The inclusion criteria were controlled clinical trials among participants aged ≥18 years with good general health. Papers that evaluated the effect of dentifrice slurry compared with water or saline on plaque regrowth during a 4-day nonbrushing period were included. Data were extracted from the eligible studies, the risk of bias was assessed, and a meta-analysis was performed where feasible. Result: The search retrieved eight eligible publications including 25 comparisons. The estimated potential risk of bias was low for all studies. Based on three different indices, overall plaque regrowth was significantly (P < 0.01) inhibited for 0.25 or more by the use of a dentifrice slurry as compared to water. All subanalysis on specific dentifrice ingredients and the overall descriptive analysis supported these findings. Conclusion: The results of this review demonstrate moderate-quality evidence for a weak inhibitory effect on plaque regrowth in favour of the use of a dentifrice intended for daily use.

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