Is Resting-State EEG Longitudinally Associated With Recovery of Clinical Neurological Impairments Early Poststroke? A Prospective Cohort Study

Mique Saes; Sarah B. Zandvliet; Aukje S. Andringa; Andreas Daffertshofer; Jos W.R. Twisk; Carel G.M. Meskers; Erwin E.H. van Wegen; Gert Kwakkel

doi:10.1177/1545968320905797

Is Resting-State EEG Longitudinally Associated With Recovery of Clinical Neurological Impairments Early Poststroke? A Prospective Cohort Study

Mique Saes, Sarah B. Zandvliet, Aukje S. Andringa, Andreas Daffertshofer, Jos W.R. Twisk, Carel G.M. Meskers, Erwin E.H. van Wegen, Gert Kwakkel^*

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

32 Downloads (Pure)

Abstract

Background. The time course of cortical activation and its relation with clinical measures may elucidate mechanisms underlying spontaneous neurobiological recovery after stroke. Objective. We aimed to investigate (1) the time course of cortical activation as revealed by EEG-based spectral characteristics during awake rest and (2) the development of these spectral characteristics in relation to global neurological and upper-limb motor recovery in the first 6 months poststroke. Methods. Resting-state EEG was measured serially in 41 patients after a first-ever ischemic stroke, within 3 and at 5, 12, and 26 weeks poststroke. We computed the brain symmetry index (BSI) and directional BSI (BSIdir) over different frequency bands (1-25 Hz, delta, theta) and delta/alpha ratio (DAR). The National Institutes of Health Stroke Scale (NIHSS) and Fugl-Meyer motor assessment of the upper extremity (FM-UE) were determined as clinical reflections of spontaneous neurobiological recovery. Longitudinal changes in spectral characteristics and within- and between-subject associations with NIHSS and FM-UE were analyzed with linear mixed models. Results. Spectral characteristics showed a gradual normalization over time, within and beyond 12 weeks poststroke. Significant within- and between-subject associations with NIHSS were found for DAR of the affected hemisphere (DAR_AH) and BSIdir_delta. BSIdir_delta also demonstrated significant within- and between-subject associations with FM-UE. Conclusions. Changes in spectral characteristics are not restricted to the time window of recovery of clinical neurological impairments. The present study suggests that decreasing DAR_AH and BSIdir_delta reflect improvement of global neurological impairments, whereas BSIdir_delta was also specifically associated with upper-limb motor recovery early poststroke.

Original language	English
Pages (from-to)	389-402
Number of pages	14
Journal	Neurorehabilitation and Neural Repair
Volume	34
Issue number	5
Early online date	4 Apr 2020
DOIs	https://doi.org/10.1177/1545968320905797
Publication status	Published - May 2020

Funding

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was funded by the European Research Council under the European Union’s Seventh Framework Programme (FP/2007–2013 ERC Grant Agreement n. 291339, project “4DEEG: A New Tool to Investigate the Spatial and Temporal Activity Patterns in the Brain”), as well as by the Dutch Brain Foundation (F2011(1)-25) and the Netherlands Organization of Scientific Research (research programme NeuroCIMT, project number 14905). Sponsors had no other involvement than financial support.

Funders	Funder number
Dutch Brain Foundation	F2011(1)-25
Netherlands Organization of Scientific Research
Northwestern University
Seventh Framework Programme	291339
European Research Council
Technische Universiteit Delft
Nederlandse Organisatie voor Wetenschappelijk Onderzoek	14905
Seventh Framework Programme

Keywords

biomarker
EEG
longitudinal study
recovery of function
stroke
upper extremity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1177/1545968320905797

Is-resting-state-eeg-longitudinally-associated-with-recovery-of-clinical-neurological-impairments-earlyFinal published version, 964 KBLicence: Article 25fa Dutch Copyright Act

https://pubmed.ncbi.nlm.nih.gov/32249674/

Persistent URL (handle)

Persistent link

Cite this

Saes, M., Zandvliet, S. B., Andringa, A. S., Daffertshofer, A., Twisk, J. W. R., Meskers, C. G. M., van Wegen, E. E. H., & Kwakkel, G. (2020). Is Resting-State EEG Longitudinally Associated With Recovery of Clinical Neurological Impairments Early Poststroke? A Prospective Cohort Study. Neurorehabilitation and Neural Repair, 34(5), 389-402. https://doi.org/10.1177/1545968320905797

@article{daeec7f522914e2682570c0035ded720,

title = "Is Resting-State EEG Longitudinally Associated With Recovery of Clinical Neurological Impairments Early Poststroke? A Prospective Cohort Study",

abstract = "Background. The time course of cortical activation and its relation with clinical measures may elucidate mechanisms underlying spontaneous neurobiological recovery after stroke. Objective. We aimed to investigate (1) the time course of cortical activation as revealed by EEG-based spectral characteristics during awake rest and (2) the development of these spectral characteristics in relation to global neurological and upper-limb motor recovery in the first 6 months poststroke. Methods. Resting-state EEG was measured serially in 41 patients after a first-ever ischemic stroke, within 3 and at 5, 12, and 26 weeks poststroke. We computed the brain symmetry index (BSI) and directional BSI (BSIdir) over different frequency bands (1-25 Hz, delta, theta) and delta/alpha ratio (DAR). The National Institutes of Health Stroke Scale (NIHSS) and Fugl-Meyer motor assessment of the upper extremity (FM-UE) were determined as clinical reflections of spontaneous neurobiological recovery. Longitudinal changes in spectral characteristics and within- and between-subject associations with NIHSS and FM-UE were analyzed with linear mixed models. Results. Spectral characteristics showed a gradual normalization over time, within and beyond 12 weeks poststroke. Significant within- and between-subject associations with NIHSS were found for DAR of the affected hemisphere (DARAH) and BSIdirdelta. BSIdirdelta also demonstrated significant within- and between-subject associations with FM-UE. Conclusions. Changes in spectral characteristics are not restricted to the time window of recovery of clinical neurological impairments. The present study suggests that decreasing DARAH and BSIdirdelta reflect improvement of global neurological impairments, whereas BSIdirdelta was also specifically associated with upper-limb motor recovery early poststroke.",

keywords = "biomarker, EEG, longitudinal study, recovery of function, stroke, upper extremity",

author = "Mique Saes and Zandvliet, {Sarah B.} and Andringa, {Aukje S.} and Andreas Daffertshofer and Twisk, {Jos W.R.} and Meskers, {Carel G.M.} and {van Wegen}, {Erwin E.H.} and Gert Kwakkel",

year = "2020",

month = may,

doi = "10.1177/1545968320905797",

language = "English",

volume = "34",

pages = "389--402",

journal = "Neurorehabilitation and Neural Repair",

issn = "1545-9683",

publisher = "SAGE Publications Inc.",

number = "5",

}

Saes, M, Zandvliet, SB, Andringa, AS, Daffertshofer, A, Twisk, JWR, Meskers, CGM, van Wegen, EEH & Kwakkel, G 2020, 'Is Resting-State EEG Longitudinally Associated With Recovery of Clinical Neurological Impairments Early Poststroke? A Prospective Cohort Study', Neurorehabilitation and Neural Repair, vol. 34, no. 5, pp. 389-402. https://doi.org/10.1177/1545968320905797

TY - JOUR

T1 - Is Resting-State EEG Longitudinally Associated With Recovery of Clinical Neurological Impairments Early Poststroke? A Prospective Cohort Study

AU - Saes, Mique

AU - Zandvliet, Sarah B.

AU - Andringa, Aukje S.

AU - Daffertshofer, Andreas

AU - Twisk, Jos W.R.

AU - Meskers, Carel G.M.

AU - van Wegen, Erwin E.H.

AU - Kwakkel, Gert

PY - 2020/5

Y1 - 2020/5

N2 - Background. The time course of cortical activation and its relation with clinical measures may elucidate mechanisms underlying spontaneous neurobiological recovery after stroke. Objective. We aimed to investigate (1) the time course of cortical activation as revealed by EEG-based spectral characteristics during awake rest and (2) the development of these spectral characteristics in relation to global neurological and upper-limb motor recovery in the first 6 months poststroke. Methods. Resting-state EEG was measured serially in 41 patients after a first-ever ischemic stroke, within 3 and at 5, 12, and 26 weeks poststroke. We computed the brain symmetry index (BSI) and directional BSI (BSIdir) over different frequency bands (1-25 Hz, delta, theta) and delta/alpha ratio (DAR). The National Institutes of Health Stroke Scale (NIHSS) and Fugl-Meyer motor assessment of the upper extremity (FM-UE) were determined as clinical reflections of spontaneous neurobiological recovery. Longitudinal changes in spectral characteristics and within- and between-subject associations with NIHSS and FM-UE were analyzed with linear mixed models. Results. Spectral characteristics showed a gradual normalization over time, within and beyond 12 weeks poststroke. Significant within- and between-subject associations with NIHSS were found for DAR of the affected hemisphere (DARAH) and BSIdirdelta. BSIdirdelta also demonstrated significant within- and between-subject associations with FM-UE. Conclusions. Changes in spectral characteristics are not restricted to the time window of recovery of clinical neurological impairments. The present study suggests that decreasing DARAH and BSIdirdelta reflect improvement of global neurological impairments, whereas BSIdirdelta was also specifically associated with upper-limb motor recovery early poststroke.

AB - Background. The time course of cortical activation and its relation with clinical measures may elucidate mechanisms underlying spontaneous neurobiological recovery after stroke. Objective. We aimed to investigate (1) the time course of cortical activation as revealed by EEG-based spectral characteristics during awake rest and (2) the development of these spectral characteristics in relation to global neurological and upper-limb motor recovery in the first 6 months poststroke. Methods. Resting-state EEG was measured serially in 41 patients after a first-ever ischemic stroke, within 3 and at 5, 12, and 26 weeks poststroke. We computed the brain symmetry index (BSI) and directional BSI (BSIdir) over different frequency bands (1-25 Hz, delta, theta) and delta/alpha ratio (DAR). The National Institutes of Health Stroke Scale (NIHSS) and Fugl-Meyer motor assessment of the upper extremity (FM-UE) were determined as clinical reflections of spontaneous neurobiological recovery. Longitudinal changes in spectral characteristics and within- and between-subject associations with NIHSS and FM-UE were analyzed with linear mixed models. Results. Spectral characteristics showed a gradual normalization over time, within and beyond 12 weeks poststroke. Significant within- and between-subject associations with NIHSS were found for DAR of the affected hemisphere (DARAH) and BSIdirdelta. BSIdirdelta also demonstrated significant within- and between-subject associations with FM-UE. Conclusions. Changes in spectral characteristics are not restricted to the time window of recovery of clinical neurological impairments. The present study suggests that decreasing DARAH and BSIdirdelta reflect improvement of global neurological impairments, whereas BSIdirdelta was also specifically associated with upper-limb motor recovery early poststroke.

KW - biomarker

KW - EEG

KW - longitudinal study

KW - recovery of function

KW - stroke

KW - upper extremity

UR - http://www.scopus.com/inward/record.url?scp=85082948406&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85082948406&partnerID=8YFLogxK

U2 - 10.1177/1545968320905797

DO - 10.1177/1545968320905797

M3 - Article

C2 - 32249674

AN - SCOPUS:85082948406

SN - 1545-9683

VL - 34

SP - 389

EP - 402

JO - Neurorehabilitation and Neural Repair

JF - Neurorehabilitation and Neural Repair

IS - 5

ER -

Is Resting-State EEG Longitudinally Associated With Recovery of Clinical Neurological Impairments Early Poststroke? A Prospective Cohort Study

Abstract

Funding

Keywords

UN SDGs

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Cite this