Is the myonuclear domain size fixed?

S.F.T. van der Meer, R. T. Jaspers, H. Degens*

*Corresponding author for this work

    Research output: Contribution to JournalArticleAcademicpeer-review


    It has been suggested that the number of myonuclei in a muscle fibre changes in proportion to the change in fibre size, resulting in a constant myonuclear domain size, defined as the cytoplasmic volume per myonucleus. The myonuclear domain size varies, however, between fibre types and is inversely related with the oxidative capacity of a fibre. Overall, the observations of an increase in myonuclear domain size during both maturational growth and overload-induced hypertrophy, and the decrease in myonuclear domain size during disuse-and ageing-associated muscle atrophy suggest that the concept of a constant myonuclear domain size needs to be treated cautiously. It also suggests that only when the myonuclear domain size exceeds a certain threshold during growth or overload-induced hypertrophy acquisition of new myonuclei is required for further fibre hypertrophy.

    Original languageEnglish
    Pages (from-to)286-297
    Number of pages12
    JournalJournal of Musculoskeletal and Neuronal Interactions
    Issue number4
    Publication statusPublished - Dec 2011


    • Ageing
    • Atrophy
    • Growth
    • Hypertrophy
    • Myonuclear domain
    • Satellite cell
    • Skeletal muscle


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