Is Vitamin D Deficiency a Confounder in Alcoholic Skeletal Muscle Myopathy?

J.W. Wijnia, J.P.M. Wielders, P.T.A.M. Lips, A. van der Wiel, C.L. Mulder, K.G.A. Nieuwenhuis

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    Background: Excessive intake of alcohol is often associated with low or subnormal levels of vitamin D even in the absence of active liver disease. As vitamin D deficiency is a well-recognized cause of myopathy, alcoholic myopathy might be related to vitamin D deficiency. Chronic alcoholic myopathy affects approximately half of chronic alcoholics and is characterized by the insidious development of muscular weakness and wasting. Although alcohol or its metabolites may have a direct toxic effect on muscles, the relationship between alcoholic myopathy and vitamin D deficiency has not been examined extensively. Methods: We reviewed the literature on alcoholic myopathy and hypovitaminosis D myopathy and compared the pathophysiological findings to designate possible mechanisms of vitamin D action in alcohol-related myopathy. Results and Conclusions: Given the strong interdependency of suboptimal levels of vitamin D, phosphate, and magnesium in chronic alcohol abuse, we hypothesize that combined deficiencies interfere with membrane and intracellular metabolic processes in chronic alcohol-related myopathy; however, it is not yet possible to define exact mechanisms of interaction. © 2012 by the Research Society on Alcoholism.
    Original languageEnglish
    Pages (from-to)E209-E215
    JournalAlcoholism, Clinical and Experimental Research
    Volume37
    DOIs
    Publication statusPublished - 2013

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    Vitamin D Deficiency
    Muscular Diseases
    Vitamin D
    Muscle
    Skeletal Muscle
    Alcohols
    Poisons
    Metabolites
    Liver
    Intracellular Membranes
    Muscle Weakness
    Alcoholics
    Alcoholism
    Membranes
    Liver Diseases
    Muscles

    Cite this

    Wijnia, J. W., Wielders, J. P. M., Lips, P. T. A. M., van der Wiel, A., Mulder, C. L., & Nieuwenhuis, K. G. A. (2013). Is Vitamin D Deficiency a Confounder in Alcoholic Skeletal Muscle Myopathy? Alcoholism, Clinical and Experimental Research, 37, E209-E215. https://doi.org/10.1111/j.1530-0277.2012.01902.x
    Wijnia, J.W. ; Wielders, J.P.M. ; Lips, P.T.A.M. ; van der Wiel, A. ; Mulder, C.L. ; Nieuwenhuis, K.G.A. / Is Vitamin D Deficiency a Confounder in Alcoholic Skeletal Muscle Myopathy?. In: Alcoholism, Clinical and Experimental Research. 2013 ; Vol. 37. pp. E209-E215.
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    title = "Is Vitamin D Deficiency a Confounder in Alcoholic Skeletal Muscle Myopathy?",
    abstract = "Background: Excessive intake of alcohol is often associated with low or subnormal levels of vitamin D even in the absence of active liver disease. As vitamin D deficiency is a well-recognized cause of myopathy, alcoholic myopathy might be related to vitamin D deficiency. Chronic alcoholic myopathy affects approximately half of chronic alcoholics and is characterized by the insidious development of muscular weakness and wasting. Although alcohol or its metabolites may have a direct toxic effect on muscles, the relationship between alcoholic myopathy and vitamin D deficiency has not been examined extensively. Methods: We reviewed the literature on alcoholic myopathy and hypovitaminosis D myopathy and compared the pathophysiological findings to designate possible mechanisms of vitamin D action in alcohol-related myopathy. Results and Conclusions: Given the strong interdependency of suboptimal levels of vitamin D, phosphate, and magnesium in chronic alcohol abuse, we hypothesize that combined deficiencies interfere with membrane and intracellular metabolic processes in chronic alcohol-related myopathy; however, it is not yet possible to define exact mechanisms of interaction. {\circledC} 2012 by the Research Society on Alcoholism.",
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    Wijnia, JW, Wielders, JPM, Lips, PTAM, van der Wiel, A, Mulder, CL & Nieuwenhuis, KGA 2013, 'Is Vitamin D Deficiency a Confounder in Alcoholic Skeletal Muscle Myopathy?' Alcoholism, Clinical and Experimental Research, vol. 37, pp. E209-E215. https://doi.org/10.1111/j.1530-0277.2012.01902.x

    Is Vitamin D Deficiency a Confounder in Alcoholic Skeletal Muscle Myopathy? / Wijnia, J.W.; Wielders, J.P.M.; Lips, P.T.A.M.; van der Wiel, A.; Mulder, C.L.; Nieuwenhuis, K.G.A.

    In: Alcoholism, Clinical and Experimental Research, Vol. 37, 2013, p. E209-E215.

    Research output: Contribution to JournalArticleAcademicpeer-review

    TY - JOUR

    T1 - Is Vitamin D Deficiency a Confounder in Alcoholic Skeletal Muscle Myopathy?

    AU - Wijnia, J.W.

    AU - Wielders, J.P.M.

    AU - Lips, P.T.A.M.

    AU - van der Wiel, A.

    AU - Mulder, C.L.

    AU - Nieuwenhuis, K.G.A.

    PY - 2013

    Y1 - 2013

    N2 - Background: Excessive intake of alcohol is often associated with low or subnormal levels of vitamin D even in the absence of active liver disease. As vitamin D deficiency is a well-recognized cause of myopathy, alcoholic myopathy might be related to vitamin D deficiency. Chronic alcoholic myopathy affects approximately half of chronic alcoholics and is characterized by the insidious development of muscular weakness and wasting. Although alcohol or its metabolites may have a direct toxic effect on muscles, the relationship between alcoholic myopathy and vitamin D deficiency has not been examined extensively. Methods: We reviewed the literature on alcoholic myopathy and hypovitaminosis D myopathy and compared the pathophysiological findings to designate possible mechanisms of vitamin D action in alcohol-related myopathy. Results and Conclusions: Given the strong interdependency of suboptimal levels of vitamin D, phosphate, and magnesium in chronic alcohol abuse, we hypothesize that combined deficiencies interfere with membrane and intracellular metabolic processes in chronic alcohol-related myopathy; however, it is not yet possible to define exact mechanisms of interaction. © 2012 by the Research Society on Alcoholism.

    AB - Background: Excessive intake of alcohol is often associated with low or subnormal levels of vitamin D even in the absence of active liver disease. As vitamin D deficiency is a well-recognized cause of myopathy, alcoholic myopathy might be related to vitamin D deficiency. Chronic alcoholic myopathy affects approximately half of chronic alcoholics and is characterized by the insidious development of muscular weakness and wasting. Although alcohol or its metabolites may have a direct toxic effect on muscles, the relationship between alcoholic myopathy and vitamin D deficiency has not been examined extensively. Methods: We reviewed the literature on alcoholic myopathy and hypovitaminosis D myopathy and compared the pathophysiological findings to designate possible mechanisms of vitamin D action in alcohol-related myopathy. Results and Conclusions: Given the strong interdependency of suboptimal levels of vitamin D, phosphate, and magnesium in chronic alcohol abuse, we hypothesize that combined deficiencies interfere with membrane and intracellular metabolic processes in chronic alcohol-related myopathy; however, it is not yet possible to define exact mechanisms of interaction. © 2012 by the Research Society on Alcoholism.

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    DO - 10.1111/j.1530-0277.2012.01902.x

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    JO - Alcoholism, Clinical and Experimental Research

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