Kaposi's sarcoma-associated herpesvirus-encoded G protein-coupled receptor ORF74 constitutively activates p44/p42 MAPK and Akt via G(i) and phospholipase C-dependent signaling pathways

M.J. Smit, D. Verzijl, P Casarosa, M. Navis, H. Timmerman, R. Leurs

Research output: Contribution to JournalArticleAcademicpeer-review

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Abstract

The G protein-coupled receptor encoded by Kaposi's sarcoma-associated herpesvirus, also referred to as ORF74, has been shown to stimulate oncogenic and angiogenic signaling pathways in a constitutively active manner. The biochemical routes linking ORF74 to these signaling pathways are poorly defined. In this study, we show that ORF74 constitutively activates p44/p42 mitogen-activated protein kinase (MAPK) and Akt via G
Original languageEnglish
Pages (from-to)1744-52
JournalJournal of Virology
Volume76
Issue number4
DOIs
Publication statusPublished - 2002

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