Keeping mRNPs in check during assembly and nuclear export

Evelina Tutucci; Françoise Stutz

doi:10.1038/nrm3119

Keeping mRNPs in check during assembly and nuclear export

Evelina Tutucci^*, Françoise Stutz

^*Corresponding author for this work

Research output: Contribution to Journal › Review article › Academic › peer-review

Abstract

The cell nucleus is an intricate organelle that coordinates multiple activities that are associated with DNA replication and gene expression. In all eukaryotes, it stores the genetic information and the machineries that control the production of mature and export-competent messenger ribonucleoproteins (mRNPs), a multistep process that is regulated in a spatial and temporal manner. Recent studies suggest that post-translational modifications play a part in coordinating the co-transcriptional assembly, remodelling and export of mRNP complexes through nuclear pores, adding a new level of regulation to the process of gene expression.

Original language	English
Pages (from-to)	377-384
Number of pages	8
Journal	Nature Reviews. Molecular Cell Biology
Volume	12
Issue number	6
DOIs	https://doi.org/10.1038/nrm3119
Publication status	Published - 1 Jun 2011
Externally published	Yes

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title = "Keeping mRNPs in check during assembly and nuclear export",

abstract = "The cell nucleus is an intricate organelle that coordinates multiple activities that are associated with DNA replication and gene expression. In all eukaryotes, it stores the genetic information and the machineries that control the production of mature and export-competent messenger ribonucleoproteins (mRNPs), a multistep process that is regulated in a spatial and temporal manner. Recent studies suggest that post-translational modifications play a part in coordinating the co-transcriptional assembly, remodelling and export of mRNP complexes through nuclear pores, adding a new level of regulation to the process of gene expression.",

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year = "2011",

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AU - Stutz, Françoise

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AB - The cell nucleus is an intricate organelle that coordinates multiple activities that are associated with DNA replication and gene expression. In all eukaryotes, it stores the genetic information and the machineries that control the production of mature and export-competent messenger ribonucleoproteins (mRNPs), a multistep process that is regulated in a spatial and temporal manner. Recent studies suggest that post-translational modifications play a part in coordinating the co-transcriptional assembly, remodelling and export of mRNP complexes through nuclear pores, adding a new level of regulation to the process of gene expression.

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JO - Nature Reviews. Molecular Cell Biology

JF - Nature Reviews. Molecular Cell Biology

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ER -

Keeping mRNPs in check during assembly and nuclear export

Abstract

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