Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk

R. Mukherjee; M. Van De Kaa; J. Garssen; R.J. Pieters; A.D. Kraneveld; L.E.M. Willemsen

doi:10.1039/c8fo02376j

Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk

R. Mukherjee, M. Van De Kaa, J. Garssen, R.J. Pieters, A.D. Kraneveld, L.E.M. Willemsen

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

© 2019 The Royal Society of Chemistry.Lactulose, a non-digestible oligosaccharide and functional food, promotes Bifidobacteria growth. Here we show that lactulose, beyond its prebiotic action, may have direct immunomodulatory effects as well. In synergy with CpG-ODN, a bacterial DNA mimetic, lactulose enhances basolateral concentrations of IFN-γ, IL-10, and galectin-9 in the co-culture model of epithelial and immune cells.

Original language	English
Pages (from-to)	33-37
Journal	Food and Function
Volume	10
Issue number	1
DOIs	https://doi.org/10.1039/c8fo02376j
Publication status	Published - 1 Jan 2019
Externally published	Yes

Funding

This study is supported by the seed grant from the Utrecht Institute of Pharmaceutical Sciences (UIPS), Utrecht University, the Netherlands.

Funders	Funder number
Utrecht Institute of Pharmaceutical Sciences
Universiteit Utrecht

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AU - Mukherjee, R.

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AU - Garssen, J.

AU - Pieters, R.J.

AU - Kraneveld, A.D.

AU - Willemsen, L.E.M.

PY - 2019/1/1

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AB - © 2019 The Royal Society of Chemistry.Lactulose, a non-digestible oligosaccharide and functional food, promotes Bifidobacteria growth. Here we show that lactulose, beyond its prebiotic action, may have direct immunomodulatory effects as well. In synergy with CpG-ODN, a bacterial DNA mimetic, lactulose enhances basolateral concentrations of IFN-γ, IL-10, and galectin-9 in the co-culture model of epithelial and immune cells.

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Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk

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