Large and fast human pyramidal neurons associate with intelligence

Natalia A. Goriounova, Djai B. Heyer, René Wilbers, Matthijs B. Verhoog, Michele Giugliano, Christophe Verbist, Joshua Obermayer, Amber Kerkhofs, Harriët Smeding, Maaike Verberne, Sander Idema, Johannes C. Baayen, Anton W. Pieneman, Christiaan P.J. de Kock, Martin Klein, Huibert D. Mansvelder

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

It is generally assumed that human intelligence relies on efficient processing by neurons in our brain. Although grey matter thickness and activity of temporal and frontal cortical areas correlate with IQ scores, no direct evidence exists that links structural and physiological properties of neurons to human intelligence. Here, we find that high IQ scores and large temporal cortical thickness associate with larger, more complex dendrites of human pyramidal neurons. We show in silico that larger dendritic trees enable pyramidal neurons to track activity of synaptic inputs with higher temporal precision, due to fast action potential kinetics. Indeed, we find that human pyramidal neurons of individuals with higher IQ scores sustain fast action potential kinetics during repeated firing. These findings provide the first evidence that human intelligence is associated with neuronal complexity, action potential kinetics and efficient information transfer from inputs to output within cortical neurons.

Original languageEnglish
Article numbere41714
Pages (from-to)1-21
Number of pages21
JournaleLife
Volume7
DOIs
Publication statusPublished - 18 Dec 2018

Fingerprint

Pyramidal Cells
Intelligence
Neurons
Action Potentials
Kinetics
Dendrites
Computer Simulation
Brain
Processing

Keywords

  • Action potentials
  • Dendrites
  • Human cortex
  • Human neurons
  • Intelligence
  • Pyramidal cells

Cite this

Goriounova, Natalia A. ; Heyer, Djai B. ; Wilbers, René ; Verhoog, Matthijs B. ; Giugliano, Michele ; Verbist, Christophe ; Obermayer, Joshua ; Kerkhofs, Amber ; Smeding, Harriët ; Verberne, Maaike ; Idema, Sander ; Baayen, Johannes C. ; Pieneman, Anton W. ; de Kock, Christiaan P.J. ; Klein, Martin ; Mansvelder, Huibert D. / Large and fast human pyramidal neurons associate with intelligence. In: eLife. 2018 ; Vol. 7. pp. 1-21.
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Large and fast human pyramidal neurons associate with intelligence. / Goriounova, Natalia A.; Heyer, Djai B.; Wilbers, René; Verhoog, Matthijs B.; Giugliano, Michele; Verbist, Christophe; Obermayer, Joshua; Kerkhofs, Amber; Smeding, Harriët; Verberne, Maaike; Idema, Sander; Baayen, Johannes C.; Pieneman, Anton W.; de Kock, Christiaan P.J.; Klein, Martin; Mansvelder, Huibert D.

In: eLife, Vol. 7, e41714, 18.12.2018, p. 1-21.

Research output: Contribution to JournalArticleAcademicpeer-review

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AU - Heyer, Djai B.

AU - Wilbers, René

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AU - Giugliano, Michele

AU - Verbist, Christophe

AU - Obermayer, Joshua

AU - Kerkhofs, Amber

AU - Smeding, Harriët

AU - Verberne, Maaike

AU - Idema, Sander

AU - Baayen, Johannes C.

AU - Pieneman, Anton W.

AU - de Kock, Christiaan P.J.

AU - Klein, Martin

AU - Mansvelder, Huibert D.

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