Last in, first out: the role of cofactor binding the flavodoxin folding.

Y.J.M. Bollen; S.M. Nabuurs; W.J.H. Berkel; C.P.M. van Mierlo

doi:10.1074/jbc.M412871200

Last in, first out: the role of cofactor binding the flavodoxin folding.

Y.J.M. Bollen, S.M. Nabuurs, W.J.H. Berkel, C.P.M. van Mierlo

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Abstract

Although many proteins require the binding of a ligand to be functional, the role of ligand binding during folding is scarcely investigated. Here, we have reported the influence of the flavin mononucleotide (FMN) cofactor on the global stability and folding kinetics of Azotobacter vinelandii holoflavodoxin. Earlier studies have revealed that A. vinelandii apoflavodoxin kinetically folds according to the four-state mechanism: I

Original language	English
Pages (from-to)	7836-7844
Journal	Journal of Biological Chemistry
Volume	280
DOIs	https://doi.org/10.1074/jbc.M412871200
Publication status	Published - 2005

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title = "Last in, first out: the role of cofactor binding the flavodoxin folding.",

abstract = "Although many proteins require the binding of a ligand to be functional, the role of ligand binding during folding is scarcely investigated. Here, we have reported the influence of the flavin mononucleotide (FMN) cofactor on the global stability and folding kinetics of Azotobacter vinelandii holoflavodoxin. Earlier studies have revealed that A. vinelandii apoflavodoxin kinetically folds according to the four-state mechanism: I",

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AU - Nabuurs, S.M.

AU - Berkel, W.J.H.

AU - van Mierlo, C.P.M.

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AB - Although many proteins require the binding of a ligand to be functional, the role of ligand binding during folding is scarcely investigated. Here, we have reported the influence of the flavin mononucleotide (FMN) cofactor on the global stability and folding kinetics of Azotobacter vinelandii holoflavodoxin. Earlier studies have revealed that A. vinelandii apoflavodoxin kinetically folds according to the four-state mechanism: I

U2 - 10.1074/jbc.M412871200

DO - 10.1074/jbc.M412871200

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VL - 280

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EP - 7844

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

ER -

Last in, first out: the role of cofactor binding the flavodoxin folding.

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