Legacy data sharing to improve drug safety assessment: the eTOX project

Ferran Sanz, François Pognan, Thomas Steger-Hartmann, Carlos Díaz, Montserrat Cases, Manuel Pastor, Philippe Marc, Joerg Wichard, Katharine Briggs, David K Watson, Thomas Kleinöder, Chihae Yang, Alexander Amberg, Maria Beaumont, Anthony J Brookes, Søren Brunak, Mark T D Cronin, Gerhard F Ecker, Sylvia Escher, Nigel Greene & 17 others Antonio Guzmán, Anne Hersey, Pascale Jacques, Lieve Lammens, Jordi Mestres, Wolfgang Muster, Helle Northeved, Marc Pinches, Javier Saiz, Nicolas Sajot, Alfonso Valencia, Johan van der Lei, Nico P E Vermeulen, Esther Vock, Gerhard Wolber, Ismael Zamora, eTOX

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The sharing of legacy preclinical safety data among pharmaceutical companies and its integration with other information sources offers unprecedented opportunities to improve the early assessment of drug safety. Here, we discuss the experience of the eTOX project, which was established through the Innovative Medicines Initiative to explore this possibility.

Original languageEnglish
Pages (from-to)811-812
Number of pages2
JournalNature Reviews Drug Discovery
Volume16
Issue number12
DOIs
Publication statusPublished - Dec 2017

Fingerprint

Information Dissemination
Safety
Pharmaceutical Preparations

Keywords

  • Drug Evaluation, Preclinical
  • Drug Industry
  • Drug-Related Side Effects and Adverse Reactions
  • Humans
  • Information Dissemination
  • Risk Assessment
  • Journal Article

Cite this

Sanz, F., Pognan, F., Steger-Hartmann, T., Díaz, C., Cases, M., Pastor, M., ... eTOX (2017). Legacy data sharing to improve drug safety assessment: the eTOX project. Nature Reviews Drug Discovery, 16(12), 811-812. https://doi.org/10.1038/nrd.2017.177
Sanz, Ferran ; Pognan, François ; Steger-Hartmann, Thomas ; Díaz, Carlos ; Cases, Montserrat ; Pastor, Manuel ; Marc, Philippe ; Wichard, Joerg ; Briggs, Katharine ; Watson, David K ; Kleinöder, Thomas ; Yang, Chihae ; Amberg, Alexander ; Beaumont, Maria ; Brookes, Anthony J ; Brunak, Søren ; Cronin, Mark T D ; Ecker, Gerhard F ; Escher, Sylvia ; Greene, Nigel ; Guzmán, Antonio ; Hersey, Anne ; Jacques, Pascale ; Lammens, Lieve ; Mestres, Jordi ; Muster, Wolfgang ; Northeved, Helle ; Pinches, Marc ; Saiz, Javier ; Sajot, Nicolas ; Valencia, Alfonso ; van der Lei, Johan ; Vermeulen, Nico P E ; Vock, Esther ; Wolber, Gerhard ; Zamora, Ismael ; eTOX. / Legacy data sharing to improve drug safety assessment : the eTOX project. In: Nature Reviews Drug Discovery. 2017 ; Vol. 16, No. 12. pp. 811-812.
@article{2bd33ad6ffe2454291fcba747579da97,
title = "Legacy data sharing to improve drug safety assessment: the eTOX project",
abstract = "The sharing of legacy preclinical safety data among pharmaceutical companies and its integration with other information sources offers unprecedented opportunities to improve the early assessment of drug safety. Here, we discuss the experience of the eTOX project, which was established through the Innovative Medicines Initiative to explore this possibility.",
keywords = "Drug Evaluation, Preclinical, Drug Industry, Drug-Related Side Effects and Adverse Reactions, Humans, Information Dissemination, Risk Assessment, Journal Article",
author = "Ferran Sanz and Fran{\cc}ois Pognan and Thomas Steger-Hartmann and Carlos D{\'i}az and Montserrat Cases and Manuel Pastor and Philippe Marc and Joerg Wichard and Katharine Briggs and Watson, {David K} and Thomas Klein{\"o}der and Chihae Yang and Alexander Amberg and Maria Beaumont and Brookes, {Anthony J} and S{\o}ren Brunak and Cronin, {Mark T D} and Ecker, {Gerhard F} and Sylvia Escher and Nigel Greene and Antonio Guzm{\'a}n and Anne Hersey and Pascale Jacques and Lieve Lammens and Jordi Mestres and Wolfgang Muster and Helle Northeved and Marc Pinches and Javier Saiz and Nicolas Sajot and Alfonso Valencia and {van der Lei}, Johan and Vermeulen, {Nico P E} and Esther Vock and Gerhard Wolber and Ismael Zamora and eTOX",
year = "2017",
month = "12",
doi = "10.1038/nrd.2017.177",
language = "English",
volume = "16",
pages = "811--812",
journal = "Nature Reviews Drug Discovery",
issn = "1474-1776",
publisher = "Nature Publishing Group",
number = "12",

}

Sanz, F, Pognan, F, Steger-Hartmann, T, Díaz, C, Cases, M, Pastor, M, Marc, P, Wichard, J, Briggs, K, Watson, DK, Kleinöder, T, Yang, C, Amberg, A, Beaumont, M, Brookes, AJ, Brunak, S, Cronin, MTD, Ecker, GF, Escher, S, Greene, N, Guzmán, A, Hersey, A, Jacques, P, Lammens, L, Mestres, J, Muster, W, Northeved, H, Pinches, M, Saiz, J, Sajot, N, Valencia, A, van der Lei, J, Vermeulen, NPE, Vock, E, Wolber, G, Zamora, I & eTOX 2017, 'Legacy data sharing to improve drug safety assessment: the eTOX project' Nature Reviews Drug Discovery, vol. 16, no. 12, pp. 811-812. https://doi.org/10.1038/nrd.2017.177

Legacy data sharing to improve drug safety assessment : the eTOX project. / Sanz, Ferran; Pognan, François; Steger-Hartmann, Thomas; Díaz, Carlos; Cases, Montserrat; Pastor, Manuel; Marc, Philippe; Wichard, Joerg; Briggs, Katharine; Watson, David K; Kleinöder, Thomas; Yang, Chihae; Amberg, Alexander; Beaumont, Maria; Brookes, Anthony J; Brunak, Søren; Cronin, Mark T D; Ecker, Gerhard F; Escher, Sylvia; Greene, Nigel; Guzmán, Antonio; Hersey, Anne; Jacques, Pascale; Lammens, Lieve; Mestres, Jordi; Muster, Wolfgang; Northeved, Helle; Pinches, Marc; Saiz, Javier; Sajot, Nicolas; Valencia, Alfonso; van der Lei, Johan; Vermeulen, Nico P E; Vock, Esther; Wolber, Gerhard; Zamora, Ismael; eTOX.

In: Nature Reviews Drug Discovery, Vol. 16, No. 12, 12.2017, p. 811-812.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Legacy data sharing to improve drug safety assessment

T2 - the eTOX project

AU - Sanz, Ferran

AU - Pognan, François

AU - Steger-Hartmann, Thomas

AU - Díaz, Carlos

AU - Cases, Montserrat

AU - Pastor, Manuel

AU - Marc, Philippe

AU - Wichard, Joerg

AU - Briggs, Katharine

AU - Watson, David K

AU - Kleinöder, Thomas

AU - Yang, Chihae

AU - Amberg, Alexander

AU - Beaumont, Maria

AU - Brookes, Anthony J

AU - Brunak, Søren

AU - Cronin, Mark T D

AU - Ecker, Gerhard F

AU - Escher, Sylvia

AU - Greene, Nigel

AU - Guzmán, Antonio

AU - Hersey, Anne

AU - Jacques, Pascale

AU - Lammens, Lieve

AU - Mestres, Jordi

AU - Muster, Wolfgang

AU - Northeved, Helle

AU - Pinches, Marc

AU - Saiz, Javier

AU - Sajot, Nicolas

AU - Valencia, Alfonso

AU - van der Lei, Johan

AU - Vermeulen, Nico P E

AU - Vock, Esther

AU - Wolber, Gerhard

AU - Zamora, Ismael

AU - eTOX

PY - 2017/12

Y1 - 2017/12

N2 - The sharing of legacy preclinical safety data among pharmaceutical companies and its integration with other information sources offers unprecedented opportunities to improve the early assessment of drug safety. Here, we discuss the experience of the eTOX project, which was established through the Innovative Medicines Initiative to explore this possibility.

AB - The sharing of legacy preclinical safety data among pharmaceutical companies and its integration with other information sources offers unprecedented opportunities to improve the early assessment of drug safety. Here, we discuss the experience of the eTOX project, which was established through the Innovative Medicines Initiative to explore this possibility.

KW - Drug Evaluation, Preclinical

KW - Drug Industry

KW - Drug-Related Side Effects and Adverse Reactions

KW - Humans

KW - Information Dissemination

KW - Risk Assessment

KW - Journal Article

U2 - 10.1038/nrd.2017.177

DO - 10.1038/nrd.2017.177

M3 - Article

VL - 16

SP - 811

EP - 812

JO - Nature Reviews Drug Discovery

JF - Nature Reviews Drug Discovery

SN - 1474-1776

IS - 12

ER -

Sanz F, Pognan F, Steger-Hartmann T, Díaz C, Cases M, Pastor M et al. Legacy data sharing to improve drug safety assessment: the eTOX project. Nature Reviews Drug Discovery. 2017 Dec;16(12):811-812. https://doi.org/10.1038/nrd.2017.177