Legacy data sharing to improve drug safety assessment: the eTOX project

Ferran Sanz; François Pognan; Thomas Steger-Hartmann; Carlos Díaz; Montserrat Cases; Manuel Pastor; Philippe Marc; Joerg Wichard; Katharine Briggs; David K Watson; Thomas Kleinöder; Chihae Yang; Alexander Amberg; Maria Beaumont; Anthony J Brookes; Søren Brunak; Mark T D Cronin; Gerhard F Ecker; Sylvia Escher; Nigel Greene; Antonio Guzmán; Anne Hersey; Pascale Jacques; Lieve Lammens; Jordi Mestres; Wolfgang Muster; Helle Northeved; Marc Pinches; Javier Saiz; Nicolas Sajot; Alfonso Valencia; Johan van der Lei; Nico P E Vermeulen; Esther Vock; Gerhard Wolber; Ismael Zamora; eTOX

doi:10.1038/nrd.2017.177

Legacy data sharing to improve drug safety assessment: the eTOX project

Ferran Sanz, François Pognan, Thomas Steger-Hartmann, Carlos Díaz, Montserrat Cases, Manuel Pastor, Philippe Marc, Joerg Wichard, Katharine Briggs, David K Watson, Thomas Kleinöder, Chihae Yang, Alexander Amberg, Maria Beaumont, Anthony J Brookes, Søren Brunak, Mark T D Cronin, Gerhard F Ecker, Sylvia Escher, Nigel GreeneAntonio Guzmán, Anne Hersey, Pascale Jacques, Lieve Lammens, Jordi Mestres, Wolfgang Muster, Helle Northeved, Marc Pinches, Javier Saiz, Nicolas Sajot, Alfonso Valencia, Johan van der Lei, Nico P E Vermeulen, Esther Vock, Gerhard Wolber, Ismael Zamora, eTOX

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The sharing of legacy preclinical safety data among pharmaceutical companies and its integration with other information sources offers unprecedented opportunities to improve the early assessment of drug safety. Here, we discuss the experience of the eTOX project, which was established through the Innovative Medicines Initiative to explore this possibility.

Original language	English
Pages (from-to)	811-812
Number of pages	2
Journal	Nature Reviews Drug Discovery
Volume	16
Issue number	12
DOIs	https://doi.org/10.1038/nrd.2017.177
Publication status	Published - Dec 2017

Keywords

Drug Evaluation, Preclinical
Drug Industry
Drug-Related Side Effects and Adverse Reactions
Humans
Information Dissemination
Journal Article
Risk Assessment

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Sanz, F., Pognan, F., Steger-Hartmann, T., Díaz, C., Cases, M., Pastor, M., Marc, P., Wichard, J., Briggs, K., Watson, D. K., Kleinöder, T., Yang, C., Amberg, A., Beaumont, M., Brookes, A. J., Brunak, S., Cronin, M. T. D., Ecker, G. F., Escher, S., ... eTOX (2017). Legacy data sharing to improve drug safety assessment: the eTOX project. Nature Reviews Drug Discovery, 16(12), 811-812. https://doi.org/10.1038/nrd.2017.177

Sanz, Ferran ; Pognan, François ; Steger-Hartmann, Thomas ; Díaz, Carlos ; Cases, Montserrat ; Pastor, Manuel ; Marc, Philippe ; Wichard, Joerg ; Briggs, Katharine ; Watson, David K ; Kleinöder, Thomas ; Yang, Chihae ; Amberg, Alexander ; Beaumont, Maria ; Brookes, Anthony J ; Brunak, Søren ; Cronin, Mark T D ; Ecker, Gerhard F ; Escher, Sylvia ; Greene, Nigel ; Guzmán, Antonio ; Hersey, Anne ; Jacques, Pascale ; Lammens, Lieve ; Mestres, Jordi ; Muster, Wolfgang ; Northeved, Helle ; Pinches, Marc ; Saiz, Javier ; Sajot, Nicolas ; Valencia, Alfonso ; van der Lei, Johan ; Vermeulen, Nico P E ; Vock, Esther ; Wolber, Gerhard ; Zamora, Ismael ; eTOX. / Legacy data sharing to improve drug safety assessment : the eTOX project. In: Nature Reviews Drug Discovery. 2017 ; Vol. 16, No. 12. pp. 811-812.

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title = "Legacy data sharing to improve drug safety assessment: the eTOX project",

abstract = "The sharing of legacy preclinical safety data among pharmaceutical companies and its integration with other information sources offers unprecedented opportunities to improve the early assessment of drug safety. Here, we discuss the experience of the eTOX project, which was established through the Innovative Medicines Initiative to explore this possibility.",

keywords = "Drug Evaluation, Preclinical, Drug Industry, Drug-Related Side Effects and Adverse Reactions, Humans, Information Dissemination, Journal Article, Risk Assessment",

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Sanz, F, Pognan, F, Steger-Hartmann, T, Díaz, C, Cases, M, Pastor, M, Marc, P, Wichard, J, Briggs, K, Watson, DK, Kleinöder, T, Yang, C, Amberg, A, Beaumont, M, Brookes, AJ, Brunak, S, Cronin, MTD, Ecker, GF, Escher, S, Greene, N, Guzmán, A, Hersey, A, Jacques, P, Lammens, L, Mestres, J, Muster, W, Northeved, H, Pinches, M, Saiz, J, Sajot, N, Valencia, A, van der Lei, J, Vermeulen, NPE, Vock, E, Wolber, G, Zamora, I & eTOX 2017, 'Legacy data sharing to improve drug safety assessment: the eTOX project', Nature Reviews Drug Discovery, vol. 16, no. 12, pp. 811-812. https://doi.org/10.1038/nrd.2017.177

Legacy data sharing to improve drug safety assessment : the eTOX project. / Sanz, Ferran; Pognan, François; Steger-Hartmann, Thomas; Díaz, Carlos; Cases, Montserrat; Pastor, Manuel; Marc, Philippe; Wichard, Joerg; Briggs, Katharine; Watson, David K; Kleinöder, Thomas; Yang, Chihae; Amberg, Alexander; Beaumont, Maria; Brookes, Anthony J; Brunak, Søren; Cronin, Mark T D; Ecker, Gerhard F; Escher, Sylvia; Greene, Nigel; Guzmán, Antonio; Hersey, Anne; Jacques, Pascale; Lammens, Lieve; Mestres, Jordi; Muster, Wolfgang; Northeved, Helle; Pinches, Marc; Saiz, Javier; Sajot, Nicolas; Valencia, Alfonso; van der Lei, Johan; Vermeulen, Nico P E; Vock, Esther; Wolber, Gerhard; Zamora, Ismael; eTOX.

In: Nature Reviews Drug Discovery, Vol. 16, No. 12, 12.2017, p. 811-812.

Research output: Contribution to Journal › Article › Academic › peer-review

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