Legal substance use and the development of a DSM-IV cannabis use disorder during adolescence: the TRAILS study.

Aims: To examine whether early onset of tobacco or alcohol use, and continued use of tobacco or alcohol in early adolescence, are related to a higher likelihood of developing a cannabis use disorder during adolescence. Design and setting: Data were used from four consecutive assessment waves of the TRacking Adolescents' Individual Lives Survey (TRAILS), a general Dutch population study. TRAILS is an ongoing longitudinal study that will follow the same group of adolescents from the ages of 10 to 24 years. Participants: The sample consisted of 1108 (58% female) adolescents (mean ages at the four assessment waves are 11.09, 13.56, 16.27 and 19.05 years, respectively) Measurements: Cannabis use disorders were assessed using the Composite International Diagnostic Interview 3.0 (CIDI). Adolescent tobacco and alcohol use were assessed using self-report questionnaires. Findings: Early-onset tobacco use [odds ratio (OR)=1.82, confidence interval (CI)=1.05-3.14, P<0.05], but not early-onset alcohol use (OR=1.33, CI=0.84-2.12, P>0.05), was associated with a higher likelihood of developing a cannabis use disorder. Similarly, adolescents who reported continued use of tobacco (OR=2.47, CI=1.02-5.98, P<0.05), but not continued use of alcohol (OR=1.71, CI=0.87-3.38, P>0.05), were more likely to develop a cannabis use disorder. Conclusions: Early-onset and continued tobacco use appear to predict the development of a cannabis use disorder in adolescence, whereas early onset and continued alcohol use do not. © 2013 Society for the Study of Addiction.