Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation

P.J.M. Wijnker; V. Sequeira Oliveira; D.B. Foster; Y.J. Li; C.G. dos Remedios; A.M. Murphy; G.J.M. Stienen; J. van der Velden

doi:10.1152/ajpheart.00580.2013

Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation

P.J.M. Wijnker, V. Sequeira Oliveira, D.B. Foster, Y.J. Li, C.G. dos Remedios, A.M. Murphy, G.J.M. Stienen, J. van der Velden

Physics of Living Systems

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Frank-Starling's law reflects the ability of the heart to adjust the force of its contraction to changes in ventricular filling, a property based on length-dependent myofilament activation (LDA). The threonine at amino acid 143 of cardiac troponin I (cTnI) is prerequisite for the length-dependent increase in Ca

Original language	English
Pages (from-to)	H1171-H1181
Journal	American Journal of Physiology. Heart and Circulatory Physiology
Volume	306
Issue number	8
DOIs	https://doi.org/10.1152/ajpheart.00580.2013
Publication status	Published - 2014

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10.1152/ajpheart.00580.2013

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Wijnker, P. J. M., Sequeira Oliveira, V., Foster, D. B., Li, Y. J., dos Remedios, C. G., Murphy, A. M., Stienen, G. J. M., & van der Velden, J. (2014). Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation. American Journal of Physiology. Heart and Circulatory Physiology, 306(8), H1171-H1181. https://doi.org/10.1152/ajpheart.00580.2013

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title = "Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation",

abstract = "Frank-Starling's law reflects the ability of the heart to adjust the force of its contraction to changes in ventricular filling, a property based on length-dependent myofilament activation (LDA). The threonine at amino acid 143 of cardiac troponin I (cTnI) is prerequisite for the length-dependent increase in Ca",

author = "P.J.M. Wijnker and {Sequeira Oliveira}, V. and D.B. Foster and Y.J. Li and {dos Remedios}, C.G. and A.M. Murphy and G.J.M. Stienen and {van der Velden}, J.",

year = "2014",

doi = "10.1152/ajpheart.00580.2013",

language = "English",

volume = "306",

pages = "H1171--H1181",

journal = "American Journal of Physiology. Heart and Circulatory Physiology",

issn = "0363-6135",

publisher = "American Physiological Society",

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Wijnker, PJM, Sequeira Oliveira, V, Foster, DB, Li, YJ, dos Remedios, CG, Murphy, AM, Stienen, GJM & van der Velden, J 2014, 'Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation', American Journal of Physiology. Heart and Circulatory Physiology, vol. 306, no. 8, pp. H1171-H1181. https://doi.org/10.1152/ajpheart.00580.2013

Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation. / Wijnker, P.J.M.; Sequeira Oliveira, V.; Foster, D.B. et al.
In: American Journal of Physiology. Heart and Circulatory Physiology, Vol. 306, No. 8, 2014, p. H1171-H1181.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation

AU - Wijnker, P.J.M.

AU - Sequeira Oliveira, V.

AU - Foster, D.B.

AU - Li, Y.J.

AU - dos Remedios, C.G.

AU - Murphy, A.M.

AU - Stienen, G.J.M.

AU - van der Velden, J.

PY - 2014

Y1 - 2014

N2 - Frank-Starling's law reflects the ability of the heart to adjust the force of its contraction to changes in ventricular filling, a property based on length-dependent myofilament activation (LDA). The threonine at amino acid 143 of cardiac troponin I (cTnI) is prerequisite for the length-dependent increase in Ca

AB - Frank-Starling's law reflects the ability of the heart to adjust the force of its contraction to changes in ventricular filling, a property based on length-dependent myofilament activation (LDA). The threonine at amino acid 143 of cardiac troponin I (cTnI) is prerequisite for the length-dependent increase in Ca

U2 - 10.1152/ajpheart.00580.2013

DO - 10.1152/ajpheart.00580.2013

M3 - Article

SN - 0363-6135

VL - 306

SP - H1171-H1181

JO - American Journal of Physiology. Heart and Circulatory Physiology

JF - American Journal of Physiology. Heart and Circulatory Physiology

IS - 8

ER -

Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation

Abstract

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