Leveraging European infrastructures to access 1 million human genomes by 2022

Gary Saunders; Michael Baudis; Regina Becker; Sergi Beltran; Christophe Béroud; Ewan Birney; Cath Brooksbank; Søren Brunak; Marc Van den Bulcke; Rachel Drysdale; Salvador Capella-Gutierrez; Paul Flicek; Francesco Florindi; Peter Goodhand; Ivo Gut; Jaap Heringa; Petr Holub; Jef Hooyberghs; Nick Juty; Thomas M. Keane; Jan O. Korbel; Ilkka Lappalainen; Brane Leskosek; Gert Matthijs; Michaela Th Mayrhofer; Andres Metspalu; Arcadi Navarro; Steven Newhouse; Tommi Nyrönen; Angela Page; Bengt Persson; Aarno Palotie; Helen Parkinson; Jordi Rambla; David Salgado; Erik Steinfelder; Morris A. Swertz; Alfonso Valencia; Susheel Varma; Niklas Blomberg; Serena Scollen

doi:10.1038/s41576-019-0156-9

Leveraging European infrastructures to access 1 million human genomes by 2022

Gary Saunders, Michael Baudis, Regina Becker, Sergi Beltran, Christophe Béroud, Ewan Birney, Cath Brooksbank, Søren Brunak, Marc Van den Bulcke, Rachel Drysdale, Salvador Capella-Gutierrez, Paul Flicek, Francesco Florindi, Peter Goodhand, Ivo Gut, Jaap Heringa, Petr Holub, Jef Hooyberghs, Nick Juty, Thomas M. KeaneJan O. Korbel, Ilkka Lappalainen, Brane Leskosek, Gert Matthijs, Michaela Th Mayrhofer, Andres Metspalu, Arcadi Navarro, Steven Newhouse, Tommi Nyrönen, Angela Page, Bengt Persson, Aarno Palotie, Helen Parkinson, Jordi Rambla, David Salgado, Erik Steinfelder, Morris A. Swertz, Alfonso Valencia, Susheel Varma, Niklas Blomberg, Serena Scollen^*

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

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Abstract

Human genomics is undergoing a step change from being a predominantly research-driven activity to one driven through health care as many countries in Europe now have nascent precision medicine programmes. To maximize the value of the genomic data generated, these data will need to be shared between institutions and across countries. In recognition of this challenge, 21 European countries recently signed a declaration to transnationally share data on at least 1 million human genomes by 2022. In this Roadmap, we identify the challenges of data sharing across borders and demonstrate that European research infrastructures are well-positioned to support the rapid implementation of widespread genomic data access.

Original language	English
Pages (from-to)	693-701
Number of pages	9
Journal	Nature Reviews Genetics
Volume	20
Issue number	11
Early online date	27 Aug 2019
DOIs	https://doi.org/10.1038/s41576-019-0156-9
Publication status	Published - Nov 2019

Funding

E.B. is a paid consultant to Oxford Nanopore, Glaxo-SmithKline and Dovetail Inc. S.Br. acknowledges funding from the Danish Agency for Science, Technology and Innovation (09–067306), Novo Nordisk Foundation (NNF14CC0001). P.F. is a member of the scientific advisory boards of Fabric Genomics, Inc., and Eagle Genomics, Ltd. The other authors declare no competing interests.

Funders	Funder number
Danish Agency for Science and Higher Education	09–067306
Novo Nordisk Fonden	NNF14CC0001

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Leveraging European infrastructures to access 1 million human genomes by 2022Final published version, 985 KBLicence: Article 25fa Dutch Copyright Act

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Saunders, G., Baudis, M., Becker, R., Beltran, S., Béroud, C., Birney, E., Brooksbank, C., Brunak, S., Van den Bulcke, M., Drysdale, R., Capella-Gutierrez, S., Flicek, P., Florindi, F., Goodhand, P., Gut, I., Heringa, J., Holub, P., Hooyberghs, J., Juty, N., ... Scollen, S. (2019). Leveraging European infrastructures to access 1 million human genomes by 2022. Nature Reviews Genetics, 20(11), 693-701. https://doi.org/10.1038/s41576-019-0156-9

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abstract = "Human genomics is undergoing a step change from being a predominantly research-driven activity to one driven through health care as many countries in Europe now have nascent precision medicine programmes. To maximize the value of the genomic data generated, these data will need to be shared between institutions and across countries. In recognition of this challenge, 21 European countries recently signed a declaration to transnationally share data on at least 1 million human genomes by 2022. In this Roadmap, we identify the challenges of data sharing across borders and demonstrate that European research infrastructures are well-positioned to support the rapid implementation of widespread genomic data access.",

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Saunders, G, Baudis, M, Becker, R, Beltran, S, Béroud, C, Birney, E, Brooksbank, C, Brunak, S, Van den Bulcke, M, Drysdale, R, Capella-Gutierrez, S, Flicek, P, Florindi, F, Goodhand, P, Gut, I, Heringa, J, Holub, P, Hooyberghs, J, Juty, N, Keane, TM, Korbel, JO, Lappalainen, I, Leskosek, B, Matthijs, G, Mayrhofer, MT, Metspalu, A, Navarro, A, Newhouse, S, Nyrönen, T, Page, A, Persson, B, Palotie, A, Parkinson, H, Rambla, J, Salgado, D, Steinfelder, E, Swertz, MA, Valencia, A, Varma, S, Blomberg, N & Scollen, S 2019, 'Leveraging European infrastructures to access 1 million human genomes by 2022', Nature Reviews Genetics, vol. 20, no. 11, pp. 693-701. https://doi.org/10.1038/s41576-019-0156-9

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AU - Beltran, Sergi

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AU - Birney, Ewan

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AU - Brunak, Søren

AU - Van den Bulcke, Marc

AU - Drysdale, Rachel

AU - Capella-Gutierrez, Salvador

AU - Flicek, Paul

AU - Florindi, Francesco

AU - Goodhand, Peter

AU - Gut, Ivo

AU - Heringa, Jaap

AU - Holub, Petr

AU - Hooyberghs, Jef

AU - Juty, Nick

AU - Keane, Thomas M.

AU - Korbel, Jan O.

AU - Lappalainen, Ilkka

AU - Leskosek, Brane

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AU - Metspalu, Andres

AU - Navarro, Arcadi

AU - Newhouse, Steven

AU - Nyrönen, Tommi

AU - Page, Angela

AU - Persson, Bengt

AU - Palotie, Aarno

AU - Parkinson, Helen

AU - Rambla, Jordi

AU - Salgado, David

AU - Steinfelder, Erik

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AU - Scollen, Serena

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Leveraging European infrastructures to access 1 million human genomes by 2022

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UN SDGs

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